| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,902,696 | 36,284,000 | 23.03% | ||
| 2 | New Leaf Venture Partners, L.L.C. | 2,344,868 | 29,311,000 | 18.61% | ||
| 3 | FRANKLIN RESOURCES INC | 2,294,566 | 27,064,000 | 17.18% | ||
| 4 | VHCP MANAGEMENT II, LLC | 1,933,582 | 22,169,000 | 14.07% | ||
| 5 | EAGLE ASSET MANAGEMENT INC | 877,984 | 10,886,000 | 6.91% | ||
| 6 | JANUS HENDERSON INVESTORS US LLC | 707,997 | 8,850,000 | 5.62% | ||
| 7 | Asset Management One Co., Ltd. | 260,370 | 3,348,000 | 2.13% | ||
| 8 | BlackRock Fund Advisors | 226,996 | 2,837,000 | 1.80% | ||
| 9 | MILLENNIUM MANAGEMENT LLC | 181,818 | 2,273,000 | 1.44% | ||
| 10 | ACUTA CAPITAL PARTNERS, LLC | 158,807 | 1,985,000 | 1.26% | ||
| 11 | VANGUARD GROUP INC | 155,444 | 1,943,000 | 1.23% | ||
| 12 | SPHERA FUNDS MANAGEMENT LTD. | 155,000 | 1,938,000 | 1.23% | ||
| 13 | VHCP Management, LLC | 135,000 | 1,688,000 | 1.07% | ||
| 14 | JPMORGAN CHASE & CO | 115,275 | 1,441,000 | 0.91% | ||
| 15 | NORTHERN TRUST CORP | 81,408 | 1,017,000 | 0.65% | ||
| 16 | STATE STREET CORP | 67,218 | 841,000 | 0.53% | ||
| 17 | GEODE CAPITAL MANAGEMENT, LLC | 60,894 | 761,000 | 0.48% | ||
| 18 | BlackRock Institutional Trust Company, N.A. | 37,184 | 465,000 | 0.30% | ||
| 19 | D. E. Shaw & Co., Inc. | 34,257 | 428,000 | 0.27% | ||
| 20 | BlackRock Investment Management, LLC | 29,262 | 366,000 | 0.23% | ||
| 21 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 25,889 | 324,000 | 0.21% | ||
| 22 | Bank of New York Mellon Corp | 19,234 | 240,000 | 0.15% | ||
| 23 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 18,455 | 231,000 | 0.15% | ||
| 24 | TIAA CREF INVESTMENT MANAGEMENT LLC | 17,676 | 221,000 | 0.14% | ||
| 25 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 15,600 | 195,000 | 0.12% | ||
| 26 | TEACHERS ADVISORS, LLC | 8,456 | 106,000 | 0.07% | ||
| 27 | Nationwide Fund Advisors | 5,024 | 63,000 | 0.04% | ||
| 28 | MORGAN STANLEY | 3,639 | 46,000 | 0.03% | ||
| 29 | BLACKROCK ADVISORS LLC | 2,908 | 36,000 | 0.02% | ||
| 30 | STRS OHIO | 2,700 | 33,000 | 0.02% | ||
| 31 | CITIGROUP INC | 2,536 | 32,000 | 0.02% | ||
| 32 | WELLS FARGO & COMPANY/MN | 2,434 | 30,000 | 0.02% | ||
| 33 | DEUTSCHE BANK AG\ | 2,116 | 26,000 | 0.02% | ||
| 34 | UBS Group AG | 1,713 | 21,000 | 0.01% | ||
| 35 | ROYAL BANK OF CANADA | 1,000 | 13,000 | 0.01% | ||
| 36 | BNP PARIBAS FINANCIAL MARKETS | 757 | 9,463 | 0.01% | ||
| 37 | Tower Research Capital LLC (TRC) | 510 | 6,000 | 0.00% | ||
| 38 | BANK OF AMERICA CORP /DE/ | 203 | 3,000 | 0.00% | ||
| 39 | BARCLAYS PLC | 113 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
