| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FRANKLIN RESOURCES INC | 2,523,423 | 31,543,000 | 17.34% | ||
| 2 | New Leaf Venture Partners, L.L.C. | 2,344,868 | 29,311,000 | 16.11% | ||
| 3 | JANUS HENDERSON INVESTORS US LLC | 2,163,510 | 27,048,000 | 14.86% | ||
| 4 | VHCP MANAGEMENT II, LLC | 1,933,582 | 24,170,000 | 13.28% | ||
| 5 | ACUTA CAPITAL PARTNERS, LLC | 1,040,265 | 13,003,000 | 7.15% | ||
| 6 | EAGLE ASSET MANAGEMENT INC | 862,432 | 10,780,000 | 5.92% | ||
| 7 | VANGUARD GROUP INC | 680,030 | 8,500,000 | 4.67% | ||
| 8 | BlackRock Fund Advisors | 517,087 | 6,464,000 | 3.55% | ||
| 9 | Opaleye Management Inc. | 280,000 | 3,500,000 | 1.92% | ||
| 10 | MILLENNIUM MANAGEMENT LLC | 278,407 | 3,480,000 | 1.91% | ||
| 11 | FMR LLC | 209,078 | 2,613,000 | 1.44% | ||
| 12 | STATE STREET CORP | 200,301 | 2,505,000 | 1.38% | ||
| 13 | GEODE CAPITAL MANAGEMENT, LLC | 164,465 | 2,055,000 | 1.13% | ||
| 14 | NORTHERN TRUST CORP | 163,851 | 2,048,000 | 1.13% | ||
| 15 | SPHERA FUNDS MANAGEMENT LTD. | 150,000 | 1,875,000 | 1.03% | ||
| 16 | BlackRock Institutional Trust Company, N.A. | 146,449 | 1,831,000 | 1.01% | ||
| 17 | VHCP Management, LLC | 135,000 | 1,688,000 | 0.93% | ||
| 18 | JPMORGAN CHASE & CO | 127,946 | 1,599,000 | 0.88% | ||
| 19 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 69,959 | 875,000 | 0.48% | ||
| 20 | BlackRock Investment Management, LLC | 64,825 | 810,000 | 0.45% | ||
| 21 | Bank of New York Mellon Corp | 61,078 | 764,000 | 0.42% | ||
| 22 | MORGAN STANLEY | 48,187 | 602,000 | 0.33% | ||
| 23 | Raymond James Financial Services Advisors, Inc. | 47,000 | 588,000 | 0.32% | ||
| 24 | TIAA CREF INVESTMENT MANAGEMENT LLC | 46,196 | 577,000 | 0.32% | ||
| 25 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 33,467 | 418,000 | 0.23% | ||
| 26 | GOLDMAN SACHS GROUP INC | 28,897 | 361,000 | 0.20% | ||
| 27 | TEACHERS ADVISORS, LLC | 28,353 | 354,000 | 0.19% | ||
| 28 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 26,247 | 328,000 | 0.18% | ||
| 29 | D. E. Shaw & Co., Inc. | 18,174 | 227,000 | 0.12% | ||
| 30 | NEW YORK STATE COMMON RETIREMENT FUND | 17,300 | 216,000 | 0.12% | ||
| 31 | CITIGROUP INC | 16,351 | 204,000 | 0.11% | ||
| 32 | RHUMBLINE ADVISERS | 16,001 | 200,000 | 0.11% | ||
| 33 | MARK SHEPTOFF FINANCIAL PLANNING, LLC | 15,900 | 199,000 | 0.11% | ||
| 34 | LPL Financial LLC | 12,671 | 162,000 | 0.09% | ||
| 35 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 12,718 | 159,000 | 0.09% | ||
| 36 | WELLS FARGO & COMPANY/MN | 11,742 | 147,000 | 0.08% | ||
| 37 | Nationwide Fund Advisors | 10,247 | 128,000 | 0.07% | ||
| 38 | BLACKROCK ADVISORS LLC | 9,933 | 124,000 | 0.07% | ||
| 39 | DEUTSCHE BANK AG\ | 9,614 | 119,000 | 0.07% | ||
| 40 | AMERICAN INTERNATIONAL GROUP, INC. | 9,341 | 117,000 | 0.06% | ||
| 41 | UBS Group AG | 4,219 | 52,000 | 0.03% | ||
| 42 | Legal & General Group Plc | 4,133 | 51,000 | 0.03% | ||
| 43 | ROYAL BANK OF CANADA | 3,390 | 43,000 | 0.02% | ||
| 44 | BANK OF AMERICA CORP /DE/ | 2,556 | 32,000 | 0.02% | ||
| 45 | BlackRock Finance, Inc. | 1,985 | 25,000 | 0.01% | ||
| 46 | PARK CIRCLE Co | 1,200 | 15,000 | 0.01% | ||
| 47 | Kistler-Tiffany Companies, LLC | 1,140 | 14,000 | 0.01% | ||
| 48 | STRS OHIO | 1,000 | 12,000 | 0.01% | ||
| 49 | BNP PARIBAS FINANCIAL MARKETS | 906 | 11,325 | 0.01% | ||
| 50 | ADVANTAGE INVESTMENT MANAGEMENT, LLC | 500 | 6,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
