| 1 |
FRANKLIN RESOURCES INC |
2,393,296 |
21,898,000 |
20.04% |
|
|
| 2 |
New Leaf Venture Partners, L.L.C. |
2,344,868 |
21,456,000 |
19.64% |
|
|
| 3 |
VHCP MANAGEMENT II, LLC |
1,933,582 |
17,692,000 |
16.19% |
|
|
| 4 |
FMR LLC |
1,133,783 |
10,374,000 |
9.49% |
|
|
| 5 |
EAGLE ASSET MANAGEMENT INC |
870,908 |
7,968,000 |
7.29% |
|
|
| 6 |
JANUS HENDERSON INVESTORS US LLC |
715,230 |
6,546,000 |
5.99% |
|
|
| 7 |
ACUTA CAPITAL PARTNERS, LLC |
385,100 |
3,524,000 |
3.23% |
|
|
| 8 |
Asset Management One Co., Ltd. |
260,456 |
2,474,000 |
2.26% |
|
|
| 9 |
VANGUARD GROUP INC |
216,614 |
1,982,000 |
1.81% |
|
|
| 10 |
BlackRock Fund Advisors |
215,117 |
1,968,000 |
1.80% |
|
|
| 11 |
MILLENNIUM MANAGEMENT LLC |
199,467 |
1,825,000 |
1.67% |
|
|
| 12 |
Opaleye Management Inc. |
185,000 |
1,693,000 |
1.55% |
|
|
| 13 |
SPHERA FUNDS MANAGEMENT LTD. |
150,000 |
1,373,000 |
1.26% |
|
|
| 14 |
VHCP Management, LLC |
135,000 |
1,235,000 |
1.13% |
|
|
| 15 |
JPMORGAN CHASE & CO |
121,150 |
1,109,000 |
1.01% |
|
|
| 16 |
STATE STREET CORP |
97,913 |
897,000 |
0.82% |
|
|
| 17 |
NORTHERN TRUST CORP |
81,408 |
745,000 |
0.68% |
|
|
| 18 |
BlackRock Institutional Trust Company, N.A. |
74,564 |
682,000 |
0.62% |
|
|
| 19 |
DAFNA Capital Management LLC |
69,177 |
633,000 |
0.58% |
|
|
| 20 |
GEODE CAPITAL MANAGEMENT, LLC |
66,744 |
610,000 |
0.56% |
|
|
| 21 |
Raymond James Financial Services Advisors, Inc. |
46,000 |
421,000 |
0.39% |
|
|
| 22 |
BlackRock Investment Management, LLC |
30,605 |
280,000 |
0.26% |
|
|
| 23 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
26,348 |
242,000 |
0.22% |
|
|
| 24 |
Bank of New York Mellon Corp |
22,343 |
204,000 |
0.19% |
|
|
| 25 |
MORGAN STANLEY |
19,174 |
175,000 |
0.16% |
|
|
| 26 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
18,475 |
169,000 |
0.15% |
|
|
| 27 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
17,676 |
162,000 |
0.15% |
|
|
| 28 |
TFS CAPITAL LLC |
13,278 |
121,000 |
0.11% |
|
|
| 29 |
D. E. Shaw & Co., Inc. |
12,256 |
112,000 |
0.10% |
|
|
| 30 |
BANK OF MONTREAL /CAN/ |
12,000 |
110,000 |
0.10% |
|
|
| 31 |
WHITE PINE CAPITAL LLC |
11,614 |
106,000 |
0.10% |
|
|
| 32 |
TEACHERS ADVISORS, LLC |
8,456 |
77,000 |
0.07% |
|
|
| 33 |
NEW YORK STATE COMMON RETIREMENT FUND |
7,100 |
65,000 |
0.06% |
|
|
| 34 |
CITIGROUP INC |
6,903 |
64,000 |
0.06% |
|
|
| 35 |
Nationwide Fund Advisors |
5,967 |
55,000 |
0.05% |
|
|
| 36 |
AMERICAN INTERNATIONAL GROUP, INC. |
4,882 |
45,000 |
0.04% |
|
|
| 37 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
4,040 |
38,000 |
0.03% |
|
|
| 38 |
BLACKROCK ADVISORS LLC |
2,908 |
27,000 |
0.02% |
|
|
| 39 |
STRS OHIO |
2,700 |
24,000 |
0.02% |
|
|
| 40 |
ROYAL BANK OF CANADA |
2,400 |
22,000 |
0.02% |
|
|
| 41 |
WELLS FARGO & COMPANY/MN |
2,434 |
22,000 |
0.02% |
|
|
| 42 |
PARK CIRCLE Co |
1,200 |
11,000 |
0.01% |
|
|
| 43 |
DEUTSCHE BANK AG\ |
1,287 |
11,000 |
0.01% |
|
|
| 44 |
MARK SHEPTOFF FINANCIAL PLANNING, LLC |
1,000 |
9,000 |
0.01% |
|
|
| 45 |
ADVANTAGE INVESTMENT MANAGEMENT, LLC |
500 |
5,000 |
0.00% |
|
|
| 46 |
BlackRock Finance, Inc. |
124 |
1,000 |
0.00% |
|
|
