| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FRANKLIN RESOURCES INC | 2,392,496 | 24,188,000 | 17.41% | ||
| 2 | New Leaf Venture Partners, L.L.C. | 2,344,868 | 23,707,000 | 17.07% | ||
| 3 | JANUS HENDERSON INVESTORS US LLC | 2,334,535 | 23,601,000 | 16.99% | ||
| 4 | VHCP MANAGEMENT II, LLC | 1,933,582 | 19,549,000 | 14.07% | ||
| 5 | EAGLE ASSET MANAGEMENT INC | 816,295 | 8,252,000 | 5.94% | ||
| 6 | ACUTA CAPITAL PARTNERS, LLC | 530,000 | 5,358,000 | 3.86% | ||
| 7 | VANGUARD GROUP INC | 464,753 | 4,699,000 | 3.38% | ||
| 8 | BlackRock Fund Advisors | 416,562 | 4,211,000 | 3.03% | ||
| 9 | MILLENNIUM MANAGEMENT LLC | 249,048 | 2,518,000 | 1.81% | ||
| 10 | Asset Management One Co., Ltd. | 246,916 | 2,424,000 | 1.75% | ||
| 11 | Opaleye Management Inc. | 225,600 | 2,281,000 | 1.64% | ||
| 12 | FMR LLC | 209,078 | 2,114,000 | 1.52% | ||
| 13 | STATE STREET CORP | 158,208 | 1,600,000 | 1.15% | ||
| 14 | SPHERA FUNDS MANAGEMENT LTD. | 150,000 | 1,517,000 | 1.09% | ||
| 15 | NORTHERN TRUST CORP | 148,847 | 1,505,000 | 1.08% | ||
| 16 | BlackRock Institutional Trust Company, N.A. | 136,781 | 1,383,000 | 1.00% | ||
| 17 | NEXTHERA CAPITAL LP | 135,836 | 1,373,000 | 0.99% | ||
| 18 | VHCP Management, LLC | 135,000 | 1,365,000 | 0.98% | ||
| 19 | JPMORGAN CHASE & CO | 116,925 | 1,182,000 | 0.85% | ||
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 75,200 | 760,000 | 0.55% | ||
| 21 | BlackRock Investment Management, LLC | 65,058 | 658,000 | 0.47% | ||
| 22 | TIAA CREF INVESTMENT MANAGEMENT LLC | 47,129 | 476,000 | 0.34% | ||
| 23 | Raymond James Financial Services Advisors, Inc. | 46,000 | 465,000 | 0.33% | ||
| 24 | Bank of New York Mellon Corp | 45,280 | 457,000 | 0.33% | ||
| 25 | GOLDMAN SACHS GROUP INC | 44,786 | 453,000 | 0.33% | ||
| 26 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 39,726 | 402,000 | 0.29% | ||
| 27 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 34,067 | 344,000 | 0.25% | ||
| 28 | TEACHERS ADVISORS, LLC | 26,203 | 265,000 | 0.19% | ||
| 29 | RAYMOND JAMES & ASSOCIATES | 23,085 | 233,000 | 0.17% | ||
| 30 | MORGAN STANLEY | 20,529 | 208,000 | 0.15% | ||
| 31 | A.R.T. Advisors, LLC | 20,391 | 206,000 | 0.15% | ||
| 32 | NEW YORK STATE COMMON RETIREMENT FUND | 17,300 | 175,000 | 0.13% | ||
| 33 | RHUMBLINE ADVISERS | 13,250 | 134,000 | 0.10% | ||
| 34 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 12,859 | 130,000 | 0.09% | ||
| 35 | MARK SHEPTOFF FINANCIAL PLANNING, LLC | 10,800 | 109,000 | 0.08% | ||
| 36 | Nationwide Fund Advisors | 10,247 | 104,000 | 0.07% | ||
| 37 | AMERICAN INTERNATIONAL GROUP, INC. | 9,352 | 94,549 | 0.07% | ||
| 38 | BlackRock Finance, Inc. | 6,354 | 64,000 | 0.05% | ||
| 39 | BLACKROCK ADVISORS LLC | 5,529 | 56,000 | 0.04% | ||
| 40 | STRS OHIO | 5,400 | 54,000 | 0.04% | ||
| 41 | BARCLAYS PLC | 3,978 | 40,000 | 0.03% | ||
| 42 | Legal & General Group Plc | 3,040 | 29,000 | 0.02% | ||
| 43 | DEUTSCHE BANK AG\ | 2,484 | 25,000 | 0.02% | ||
| 44 | ROYAL BANK OF CANADA | 2,400 | 24,000 | 0.02% | ||
| 45 | WELLS FARGO & COMPANY/MN | 2,413 | 24,000 | 0.02% | ||
| 46 | UBS Group AG | 1,810 | 18,000 | 0.01% | ||
| 47 | CITIGROUP INC | 1,624 | 16,000 | 0.01% | ||
| 48 | Kistler-Tiffany Companies, LLC | 1,140 | 12,000 | 0.01% | ||
| 49 | PARK CIRCLE Co | 1,200 | 12,000 | 0.01% | ||
| 50 | BlackRock Japan Co. Ltd | 769 | 8,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
