| 1 |
FRANKLIN RESOURCES INC |
2,494,596 |
25,968,000 |
17.49% |
|
|
| 2 |
New Leaf Venture Partners, L.L.C. |
2,344,868 |
24,410,000 |
16.44% |
|
|
| 3 |
JANUS HENDERSON INVESTORS US LLC |
2,277,220 |
23,706,000 |
15.96% |
|
|
| 4 |
VHCP MANAGEMENT II, LLC |
1,933,582 |
20,129,000 |
13.55% |
|
|
| 5 |
EAGLE ASSET MANAGEMENT INC |
839,511 |
8,739,000 |
5.88% |
|
|
| 6 |
ACUTA CAPITAL PARTNERS, LLC |
703,000 |
7,318,000 |
4.93% |
|
|
| 7 |
VANGUARD GROUP INC |
668,443 |
6,958,000 |
4.69% |
|
|
| 8 |
BlackRock Fund Advisors |
445,673 |
4,639,000 |
3.12% |
|
|
| 9 |
MILLENNIUM MANAGEMENT LLC |
280,879 |
2,924,000 |
1.97% |
|
|
| 10 |
Opaleye Management Inc. |
280,000 |
2,915,000 |
1.96% |
|
|
| 11 |
Asset Management One Co., Ltd. |
223,786 |
2,309,000 |
1.55% |
|
|
| 12 |
FMR LLC |
209,078 |
2,177,000 |
1.47% |
|
|
| 13 |
STATE STREET CORP |
189,442 |
1,972,000 |
1.33% |
|
|
| 14 |
GEODE CAPITAL MANAGEMENT, LLC |
161,352 |
1,679,000 |
1.13% |
|
|
| 15 |
NORTHERN TRUST CORP |
155,157 |
1,615,000 |
1.09% |
|
|
| 16 |
SPHERA FUNDS MANAGEMENT LTD. |
150,000 |
1,562,000 |
1.05% |
|
|
| 17 |
BlackRock Institutional Trust Company, N.A. |
140,310 |
1,461,000 |
0.98% |
|
|
| 18 |
VHCP Management, LLC |
135,000 |
1,405,000 |
0.95% |
|
|
| 19 |
JPMORGAN CHASE & CO |
125,375 |
1,305,000 |
0.88% |
|
|
| 20 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
65,647 |
684,000 |
0.46% |
|
|
| 21 |
BlackRock Investment Management, LLC |
64,977 |
676,000 |
0.46% |
|
|
| 22 |
Bank of New York Mellon Corp |
51,755 |
539,000 |
0.36% |
|
|
| 23 |
Raymond James Financial Services Advisors, Inc. |
47,000 |
489,000 |
0.33% |
|
|
| 24 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
45,259 |
471,000 |
0.32% |
|
|
| 25 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
34,367 |
358,000 |
0.24% |
|
|
| 26 |
TEACHERS ADVISORS, LLC |
26,203 |
273,000 |
0.18% |
|
|
| 27 |
MORGAN STANLEY |
22,549 |
235,000 |
0.16% |
|
|
| 28 |
REGENTATLANTIC CAPITAL LLC |
22,500 |
234,000 |
0.16% |
|
|
| 29 |
NEW YORK STATE COMMON RETIREMENT FUND |
17,300 |
180,000 |
0.12% |
|
|
| 30 |
RHUMBLINE ADVISERS |
14,950 |
156,000 |
0.11% |
|
|
| 31 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
12,461 |
130,000 |
0.09% |
|
|
| 32 |
MARK SHEPTOFF FINANCIAL PLANNING, LLC |
10,800 |
112,000 |
0.08% |
|
|
| 33 |
Nationwide Fund Advisors |
10,247 |
107,000 |
0.07% |
|
|
| 34 |
BLACKROCK ADVISORS LLC |
9,752 |
102,000 |
0.07% |
|
|
| 35 |
TLP GROUP LLC |
9,792 |
102,000 |
0.07% |
|
|
| 36 |
AMERICAN INTERNATIONAL GROUP, INC. |
9,366 |
97,500 |
0.07% |
|
|
| 37 |
WELLS FARGO & COMPANY/MN |
6,535 |
68,000 |
0.05% |
|
|
| 38 |
BlackRock Finance, Inc. |
6,354 |
66,000 |
0.04% |
|
|
| 39 |
MYCIO WEALTH PARTNERS, LLC |
5,350 |
56,000 |
0.04% |
|
|
| 40 |
Legal & General Group Plc |
3,040 |
32,000 |
0.02% |
|
|
| 41 |
DEUTSCHE BANK AG\ |
2,674 |
27,000 |
0.02% |
|
|
| 42 |
ROYAL BANK OF CANADA |
2,400 |
25,000 |
0.02% |
|
|
| 43 |
Tower Research Capital LLC (TRC) |
1,973 |
21,000 |
0.01% |
|
|
| 44 |
UBS Group AG |
1,710 |
18,000 |
0.01% |
|
|
| 45 |
BNP PARIBAS FINANCIAL MARKETS |
1,236 |
12,867 |
0.01% |
|
|
| 46 |
PARK CIRCLE Co |
1,200 |
12,000 |
0.01% |
|
|
| 47 |
Kistler-Tiffany Companies, LLC |
1,140 |
12,000 |
0.01% |
|
|
| 48 |
STRS OHIO |
1,000 |
10,000 |
0.01% |
|
|
| 49 |
BANK OF AMERICA CORP /DE/ |
675 |
7,000 |
0.00% |
|
|
| 50 |
ADVANTAGE INVESTMENT MANAGEMENT, LLC |
500 |
5,000 |
0.00% |
|
|
