| 1 |
FRANKLIN RESOURCES INC |
2,633,023 |
23,987,000 |
17.57% |
|
|
| 2 |
New Leaf Venture Partners, L.L.C. |
2,344,868 |
21,362,000 |
15.65% |
|
|
| 3 |
JANUS HENDERSON INVESTORS US LLC |
2,115,566 |
19,272,000 |
14.12% |
|
|
| 4 |
VHCP MANAGEMENT II, LLC |
1,933,582 |
17,615,000 |
12.90% |
|
|
| 5 |
ACUTA CAPITAL PARTNERS, LLC |
1,351,516 |
12,312,000 |
9.02% |
|
|
| 6 |
EAGLE ASSET MANAGEMENT INC |
899,968 |
8,198,000 |
6.00% |
|
|
| 7 |
BlackRock Finance, Inc. |
735,332 |
6,698,000 |
4.91% |
|
|
| 8 |
VANGUARD GROUP INC |
700,003 |
6,377,000 |
4.67% |
|
|
| 9 |
MILLENNIUM MANAGEMENT LLC |
354,578 |
3,230,000 |
2.37% |
|
|
| 10 |
Opaleye Management Inc. |
280,000 |
2,550,000 |
1.87% |
|
|
| 11 |
STATE STREET CORP |
238,443 |
2,172,000 |
1.59% |
|
|
| 12 |
NORTHERN TRUST CORP |
177,433 |
1,617,000 |
1.18% |
|
|
| 13 |
GEODE CAPITAL MANAGEMENT, LLC |
172,646 |
1,572,000 |
1.15% |
|
|
| 14 |
SPHERA FUNDS MANAGEMENT LTD. |
150,000 |
1,367,000 |
1.00% |
|
|
| 15 |
REGENTATLANTIC CAPITAL LLC |
135,000 |
1,230,000 |
0.90% |
|
|
| 16 |
JPMORGAN CHASE & CO |
120,675 |
1,099,000 |
0.80% |
|
|
| 17 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
74,747 |
681,000 |
0.50% |
|
|
| 18 |
Bank of New York Mellon Corp |
61,171 |
557,000 |
0.41% |
|
|
| 19 |
FMR LLC |
51,678 |
471,000 |
0.34% |
|
|
| 20 |
Raymond James Financial Services Advisors, Inc. |
48,000 |
437,000 |
0.32% |
|
|
| 21 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
44,505 |
405,000 |
0.30% |
|
|
| 22 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
39,700 |
362,000 |
0.27% |
|
|
| 23 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
32,667 |
298,000 |
0.22% |
|
|
| 24 |
RENAISSANCE TECHNOLOGIES LLC |
32,600 |
297,000 |
0.22% |
|
|
| 25 |
TEACHERS ADVISORS, LLC |
28,353 |
258,000 |
0.19% |
|
|
| 26 |
D. E. Shaw & Co., Inc. |
28,135 |
256,000 |
0.19% |
|
|
| 27 |
TFS CAPITAL LLC |
22,993 |
209,000 |
0.15% |
|
|
| 28 |
MORGAN STANLEY |
21,843 |
199,000 |
0.15% |
|
|
| 29 |
NEW YORK STATE COMMON RETIREMENT FUND |
17,301 |
158,000 |
0.12% |
|
|
| 30 |
Spark Investment Management LLC |
17,265 |
157,000 |
0.11% |
|
|
| 31 |
RHUMBLINE ADVISERS |
16,765 |
153,000 |
0.11% |
|
|
| 32 |
Trexquant Investment LP |
15,669 |
143,000 |
0.10% |
|
|
| 33 |
MARK SHEPTOFF FINANCIAL PLANNING, LLC |
15,401 |
140,000 |
0.10% |
|
|
| 34 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
14,350 |
131,000 |
0.10% |
|
|
| 35 |
WELLS FARGO & COMPANY/MN |
11,942 |
109,000 |
0.08% |
|
|
| 36 |
RUSSELL INVESTMENTS GROUP, LTD. |
10,226 |
93,000 |
0.07% |
|
|
| 37 |
AMERICAN INTERNATIONAL GROUP, INC. |
10,011 |
91,000 |
0.07% |
|
|
| 38 |
Nationwide Fund Advisors |
9,269 |
84,000 |
0.06% |
|
|
| 39 |
Legal & General Group Plc |
4,056 |
37,000 |
0.03% |
|
|
| 40 |
DEUTSCHE BANK AG\ |
3,924 |
35,000 |
0.03% |
|
|
| 41 |
BANK OF AMERICA CORP /DE/ |
3,387 |
31,000 |
0.02% |
|
|
| 42 |
ROYAL BANK OF CANADA |
3,033 |
28,000 |
0.02% |
|
|
| 43 |
PARK CIRCLE Co |
1,200 |
11,000 |
0.01% |
|
|
| 44 |
Kistler-Tiffany Companies, LLC |
1,140 |
10,000 |
0.01% |
|
|
| 45 |
STRS OHIO |
1,000 |
9,000 |
0.01% |
|
|
| 46 |
ADVANTAGE INVESTMENT MANAGEMENT, LLC |
900 |
8,000 |
0.01% |
|
|
| 47 |
Ameritas Investment Partners, Inc. |
906 |
8,000 |
0.01% |
|
|
| 48 |
UBS Group AG |
463 |
4,000 |
0.00% |
|
|
| 49 |
MEEDER ASSET MANAGEMENT INC |
253 |
2,000 |
0.00% |
|
|
| 50 |
CITIGROUP INC |
85 |
1,000 |
0.00% |
|
|
