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IONIS PHARMACEUTICALS INC
IONIS PHARMACEUTICALS INC. Institutional holdings reported to the SEC.

Institutional Holders (2016Q2)
Portfolio Summary: 310 Institutional holders with a total value of $2,635,521,661.
#
Manager Name
Shares
Value ($)
%
Options
Notes
51 CREDIT SUISSE AG/ 339,044 7,897,000 0.30%
52 Swiss National Bank 338,200 7,877,000 0.30%
53 Sumitomo Mitsui Trust Group, Inc. 329,758 7,680,000 0.29%
54 Granahan Investment Management, LLC 273,900 6,379,000 0.24%
55 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 254,739 5,933,000 0.23%
56 CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM 239,200 5,571,000 0.21%
57 VAN ECK ASSOCIATES CORP 232,391 5,412,000 0.21%
58 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 207,936 4,843,000 0.18%
59 GOLDMAN SACHS GROUP INC 206,800 4,816,000 0.18% Call
60 EDMOND DE ROTHSCHILD ASSET MANAGEMENT (FRANCE) 200,000 4,658,000 0.18%
61 EDMOND DE ROTHSCHILD HOLDING S.A. 200,000 4,658,000 0.18%
62 TOBAM 198,811 4,630,000 0.18%
63 ROTHSCHILD & CO ASSET MANAGEMENT US INC. 189,994 4,425,000 0.17%
64 Mizuho Trust & Banking Co., Ltd. 185,348 4,317,000 0.16%
65 RENAISSANCE TECHNOLOGIES LLC 183,100 4,264,000 0.16%
66 UBS Group AG 180,000 4,192,000 0.16% Call
67 STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 175,480 4,087,000 0.16%
68 ALPS ADVISORS INC 169,676 3,952,000 0.15%
69 ROYAL BANK OF CANADA 167,575 3,902,000 0.15%
70 TWO SIGMA ADVISERS, LP 165,711 3,859,000 0.15%
71 JANE STREET GROUP, LLC 160,800 3,745,000 0.14% Call
72 BLACKROCK ADVISORS LLC 156,999 3,657,000 0.14%
73 AMP Capital Investors Ltd 155,639 3,602,000 0.14%
74 RAINIER INVESTMENT MANAGEMENT LLC 154,490 3,598,000 0.14%
75 GOLDMAN SACHS GROUP INC 152,400 3,549,000 0.13% Put
76 GUGGENHEIM CAPITAL LLC 147,037 3,424,000 0.13%
77 BlackRock Japan Co. Ltd 145,300 3,384,000 0.13%
78 APG Asset Management N.V. 143,564 3,344,000 0.13%
79 BARCLAYS PLC 140,666 3,276,000 0.12%
80 JACOBS LEVY EQUITY MANAGEMENT, INC 136,900 3,188,000 0.12%
81 RHUMBLINE ADVISERS 136,547 3,180,000 0.12%
82 SEI INVESTMENTS CO 134,430 3,131,000 0.12%
83 SONORA INVESTMENT MANAGEMENT, LLC 123,568 2,877,899 0.11%
84 TEACHERS ADVISORS, LLC 121,204 2,823,000 0.11%
85 CITIGROUP INC 117,413 2,734,000 0.10%
86 GROUP ONE TRADING LLC 113,399 2,641,000 0.10%
87 WOLVERINE ASSET MANAGEMENT LLC 108,600 2,529,000 0.10% Put
88 BELLEVUE GROUP AG 108,000 2,515,000 0.10%
89 WOLVERINE TRADING LP /BD 1,034 2,393,710 0.09% Call
90 BlackRock Finance, Inc. 101,193 2,357,000 0.09%
91 State of New Jersey Common Pension Fund D 100,000 2,329,000 0.09%
92 PERCEPTIVE ADVISORS LLC 100,000 2,329,000 0.09% Put
93 NATIXIS ADVISORS, LLC 97,485 2,270,000 0.09%
94 ALLIANCEBERNSTEIN L.P. 94,634 2,204,000 0.08%
95 ProShare Advisors LLC 93,913 2,187,000 0.08%
96 UBS Group AG 90,500 2,108,000 0.08% Put
97 IRONBRIDGE CAPITAL MANAGEMENT LP 84,975 1,979,000 0.08%
98 WOLVERINE TRADING LP /BD 842 1,949,230 0.07% Put
99 CAPITAL FUND MANAGEMENT S.A. 83,664 1,949,000 0.07%
100 STATE OF WISCONSIN INVESTMENT BOARD 80,030 1,864,000 0.07%
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From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.