| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WELLINGTON MANAGEMENT GROUP LLP | 3,122,471 | 40,905,000 | 19.78% | ||
| 2 | FMR LLC | 2,712,142 | 35,529,000 | 17.18% | ||
| 3 | PFM Health Sciences, LP | 1,669,524 | 21,871,000 | 10.58% | ||
| 4 | PERCEPTIVE ADVISORS LLC | 553,154 | 14,492,000 | 7.01% | ||
| 5 | Cormorant Asset Management, LP | 1,000,000 | 13,100,000 | 6.33% | SH | |
| 6 | BlackRock Finance, Inc. | 853,709 | 11,184,000 | 5.41% | ||
| 7 | VANGUARD GROUP INC | 764,919 | 10,020,000 | 4.85% | ||
| 8 | MILLENNIUM MANAGEMENT LLC | 543,697 | 7,122,000 | 3.44% | ||
| 9 | JPMORGAN CHASE & CO | 476,575 | 6,243,000 | 3.02% | ||
| 10 | CASDIN CAPITAL, LLC | 395,000 | 5,175,000 | 2.50% | ||
| 11 | DEERFIELD MANAGEMENT COMPANY, L.P. | 279,752 | 3,665,000 | 1.77% | ||
| 12 | DRIEHAUS CAPITAL MANAGEMENT LLC | 266,767 | 3,495,000 | 1.69% | ||
| 13 | STATE STREET CORP | 232,581 | 3,048,000 | 1.47% | ||
| 14 | Hudson Bay Capital Management LP | 210,000 | 2,751,000 | 1.33% | ||
| 15 | NORTHERN TRUST CORP | 202,983 | 2,658,000 | 1.29% | ||
| 16 | MARSHALL WACE NORTH AMERICA, L.P. | 155,274 | 2,019,000 | 0.98% | ||
| 17 | GEODE CAPITAL MANAGEMENT, LLC | 146,707 | 1,921,000 | 0.93% | ||
| 18 | PRICE T ROWE ASSOCIATES INC /MD/ | 141,186 | 1,850,000 | 0.89% | ||
| 19 | OXFORD ASSET MANAGEMENT LLP | 134,108 | 1,757,000 | 0.85% | ||
| 20 | TIAA CREF INVESTMENT MANAGEMENT LLC | 102,283 | 1,340,000 | 0.65% | ||
| 21 | BAKER BROS. ADVISORS LP | 100,000 | 1,310,000 | 0.63% | ||
| 22 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 82,945 | 1,087,000 | 0.53% | ||
| 23 | Bank of New York Mellon Corp | 63,208 | 828,000 | 0.40% | ||
| 24 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 57,546 | 754,000 | 0.36% | ||
| 25 | D. E. Shaw & Co., Inc. | 54,236 | 711,000 | 0.34% | ||
| 26 | DEUTSCHE BANK AG\ | 49,315 | 644,000 | 0.31% | ||
| 27 | GOLDMAN SACHS GROUP INC | 48,762 | 639,000 | 0.31% | ||
| 28 | Fernwood Investment Management, LLC | 48,393 | 634,000 | 0.31% | ||
| 29 | ESSEX INVESTMENT MANAGEMENT CO LLC | 48,000 | 629,000 | 0.30% | ||
| 30 | HARBOURVEST PARTNERS LLC | 44,145 | 578,000 | 0.28% | ||
| 31 | VICTORY CAPITAL MANAGEMENT INC | 39,915 | 523,000 | 0.25% | ||
| 32 | TFS CAPITAL LLC | 35,615 | 467,000 | 0.23% | ||
| 33 | MARTINGALE ASSET MANAGEMENT L P | 32,400 | 425,000 | 0.21% | ||
| 34 | Swiss National Bank | 31,790 | 416,000 | 0.20% | ||
| 35 | Hutchin Hill Capital, LP | 31,300 | 410,000 | 0.20% | ||
| 36 | Spark Investment Management LLC | 31,200 | 408,000 | 0.20% | ||
| 37 | TEACHERS ADVISORS, LLC | 30,667 | 402,000 | 0.19% | ||
| 38 | FIDUCIARY TRUST CO | 30,612 | 401,000 | 0.19% | ||
| 39 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 30,599 | 401,000 | 0.19% | ||
| 40 | ALPS ADVISORS INC | 28,393 | 372,000 | 0.18% | ||
| 41 | Partner Investment Management, L.P. | 27,370 | 359,000 | 0.17% | ||
| 42 | PRELUDE CAPITAL MANAGEMENT, LLC | 24,900 | 326,000 | 0.16% | ||
| 43 | MORGAN STANLEY | 24,402 | 319,000 | 0.15% | ||
| 44 | PANAGORA ASSET MANAGEMENT INC | 22,931 | 300,000 | 0.15% | ||
| 45 | VIRTUS ETF ADVISERS LLC | 21,407 | 280,000 | 0.14% | ||
| 46 | Dynamic Technology Lab Private Ltd | 19,498 | 255,000 | 0.12% | ||
| 47 | Numeric Investors LLC | 19,400 | 254,000 | 0.12% | ||
| 48 | NEW YORK STATE COMMON RETIREMENT FUND | 18,893 | 247,000 | 0.12% | ||
| 49 | WELLS FARGO & COMPANY/MN | 18,539 | 243,000 | 0.12% | ||
| 50 | RHUMBLINE ADVISERS | 18,489 | 242,000 | 0.12% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
