| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 5,397,698 | 7,827,000 | 30.46% | ||
| 2 | FMR LLC | 4,893,322 | 7,095,000 | 27.61% | ||
| 3 | New Leaf Venture Partners, L.L.C. | 2,059,283 | 2,986,000 | 11.62% | ||
| 4 | FIL Ltd | 1,688,870 | 2,449,000 | 9.53% | ||
| 5 | BAKER BROS. ADVISORS LP | 1,251,881 | 1,815,000 | 7.06% | ||
| 6 | VANGUARD GROUP INC | 513,944 | 745,000 | 2.90% | ||
| 7 | Weiss Multi-Strategy Advisers LLC | 350,000 | 508,000 | 1.98% | ||
| 8 | MILLENNIUM MANAGEMENT LLC | 272,699 | 395,000 | 1.54% | ||
| 9 | Rock Springs Capital Management LP | 271,370 | 393,000 | 1.53% | ||
| 10 | Artal Group S.A. | 234,493 | 340,000 | 1.32% | ||
| 11 | GEODE CAPITAL MANAGEMENT, LLC | 119,291 | 172,000 | 0.67% | ||
| 12 | RENAISSANCE TECHNOLOGIES LLC | 88,300 | 128,000 | 0.50% | ||
| 13 | GOLDMAN SACHS GROUP INC | 80,471 | 117,000 | 0.46% | ||
| 14 | ELEMENT CAPITAL MANAGEMENT LLC | 62,246 | 90,000 | 0.35% | ||
| 15 | BlackRock Finance, Inc. | 58,078 | 84,000 | 0.33% | ||
| 16 | LMR Partners LLP | 55,027 | 80,000 | 0.31% | ||
| 17 | WELLS FARGO & COMPANY/MN | 55,225 | 80,000 | 0.31% | ||
| 18 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 50,800 | 74,000 | 0.29% | ||
| 19 | NORTHERN TRUST CORP | 39,428 | 57,000 | 0.22% | ||
| 20 | Paloma Partners Management Co | 31,800 | 46,000 | 0.18% | ||
| 21 | A.R.T. Advisors, LLC | 31,245 | 45,000 | 0.18% | ||
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 22,767 | 33,000 | 0.13% | ||
| 23 | MORGAN STANLEY | 19,152 | 28,000 | 0.11% | ||
| 24 | STATE STREET CORP | 16,100 | 23,000 | 0.09% | ||
| 25 | BANK OF AMERICA CORP /DE/ | 14,953 | 22,000 | 0.09% | ||
| 26 | Virtu KCG Holdings LLC | 12,467 | 18,000 | 0.07% | ||
| 27 | JPMORGAN CHASE & CO | 10,713 | 16,000 | 0.06% | ||
| 28 | Tower Research Capital LLC (TRC) | 10,035 | 14,000 | 0.05% | ||
| 29 | BARCLAYS PLC | 5,809 | 8,000 | 0.03% | ||
| 30 | DEUTSCHE BANK AG\ | 3,291 | 4,000 | 0.02% | ||
| 31 | MEEDER ASSET MANAGEMENT INC | 731 | 1,000 | 0.00% | ||
| 32 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 729 | 1,000 | 0.00% | ||
| 33 | PANAGORA ASSET MANAGEMENT INC | 448 | 1,000 | 0.00% | ||
| 34 | CITIGROUP INC | 1 | 0 | 0.00% | ||
| 35 | UBS Group AG | 339 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
