| 1 |
RA CAPITAL MANAGEMENT, L.P. |
7,088,651 |
230,168,000 |
50.41% |
|
|
| 2 |
FMR LLC |
1,861,849 |
60,454,000 |
13.24% |
|
|
| 3 |
New Leaf Venture Partners, L.L.C. |
784,159 |
25,462,000 |
5.58% |
|
|
| 4 |
FORESITE CAPITAL MANAGEMENT III, LLC |
727,496 |
23,622,000 |
5.17% |
|
|
| 5 |
Redmile Group, LLC |
701,822 |
22,788,000 |
4.99% |
|
|
| 6 |
PERCEPTIVE ADVISORS LLC |
683,448 |
22,191,000 |
4.86% |
|
|
| 7 |
Cormorant Asset Management, LP |
507,907 |
16,492,000 |
3.61% |
|
|
| 8 |
EVENTIDE ASSET MANAGEMENT, LLC |
380,000 |
12,339,000 |
2.70% |
|
|
| 9 |
CLOUGH CAPITAL PARTNERS L P |
246,903 |
8,017,000 |
1.76% |
|
|
| 10 |
BlackRock Fund Advisors |
203,599 |
6,611,000 |
1.45% |
|
|
| 11 |
PRICE T ROWE ASSOCIATES INC /MD/ |
142,320 |
4,621,000 |
1.01% |
|
|
| 12 |
VANGUARD GROUP INC |
122,198 |
3,967,000 |
0.87% |
|
|
| 13 |
STATE STREET CORP |
102,838 |
3,339,000 |
0.73% |
|
|
| 14 |
NORTHERN TRUST CORP |
91,433 |
2,969,000 |
0.65% |
|
|
| 15 |
JENNISON ASSOCIATES LLC |
75,435 |
2,449,000 |
0.54% |
|
|
| 16 |
GEODE CAPITAL MANAGEMENT, LLC |
67,231 |
2,182,000 |
0.48% |
|
|
| 17 |
BlackRock Institutional Trust Company, N.A. |
57,306 |
1,861,000 |
0.41% |
|
|
| 18 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
28,000 |
909,000 |
0.20% |
|
|
| 19 |
BlackRock Investment Management, LLC |
27,959 |
908,000 |
0.20% |
|
|
| 20 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
21,608 |
702,000 |
0.15% |
|
|
| 21 |
Bank of New York Mellon Corp |
21,343 |
693,000 |
0.15% |
|
|
| 22 |
Vident Investment Advisory, LLC |
19,342 |
628,000 |
0.14% |
|
|
| 23 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
15,709 |
510,000 |
0.11% |
|
|
| 24 |
TEACHERS ADVISORS, LLC |
11,898 |
386,000 |
0.08% |
|
|
| 25 |
DESCHUTES PORTFOLIO STRATEGY, LLC |
10,296 |
334,000 |
0.07% |
|
|
| 26 |
RHUMBLINE ADVISERS |
7,862 |
255,000 |
0.06% |
|
|
| 27 |
NEW YORK STATE COMMON RETIREMENT FUND |
7,700 |
250,000 |
0.05% |
|
|
| 28 |
Lesa Sroufe & Co |
6,440 |
209,000 |
0.05% |
|
|
| 29 |
STRS OHIO |
6,000 |
194,000 |
0.04% |
|
|
| 30 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
5,420 |
176,000 |
0.04% |
|
|
| 31 |
Nationwide Fund Advisors |
4,661 |
151,000 |
0.03% |
|
|
| 32 |
AMERICAN INTERNATIONAL GROUP, INC. |
4,264 |
138,452 |
0.03% |
|
|
| 33 |
BLACKROCK ADVISORS LLC |
4,264 |
138,000 |
0.03% |
|
|
| 34 |
WELLS FARGO & COMPANY/MN |
4,200 |
136,000 |
0.03% |
|
|
| 35 |
UBS Group AG |
3,000 |
97,000 |
0.02% |
|
|
| 36 |
MORGAN STANLEY |
2,309 |
75,000 |
0.02% |
|
|
| 37 |
DEUTSCHE BANK AG\ |
1,216 |
39,000 |
0.01% |
|
|
| 38 |
CITIGROUP INC |
605 |
20,000 |
0.00% |
|
|
| 39 |
BNP PARIBAS FINANCIAL MARKETS |
552 |
17,923 |
0.00% |
|
|
| 40 |
PRENTISS SMITH & CO INC |
500 |
16,000 |
0.00% |
|
|
| 41 |
BlackRock Finance, Inc. |
373 |
12,000 |
0.00% |
|
|
| 42 |
ROYAL BANK OF CANADA |
300 |
10,000 |
0.00% |
|
|
| 43 |
BANK OF AMERICA CORP /DE/ |
307 |
10,000 |
0.00% |
|
|
| 44 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
220 |
7,000 |
0.00% |
|
|
| 45 |
ACROSPIRE INVESTMENT MANAGEMENT LLC |
164 |
5,000 |
0.00% |
|
|
| 46 |
BARCLAYS PLC |
47 |
1,000 |
0.00% |
|
|
