| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | RA CAPITAL MANAGEMENT, L.P. | 7,088,651 | 185,368,000 | 47.74% | ||
| 2 | FMR LLC | 1,893,756 | 49,522,000 | 12.75% | ||
| 3 | Redmile Group, LLC | 951,712 | 24,887,000 | 6.41% | ||
| 4 | PERCEPTIVE ADVISORS LLC | 665,198 | 18,088,000 | 4.66% | ||
| 5 | FORESITE CAPITAL MANAGEMENT III, LLC | 676,128 | 17,681,000 | 4.55% | ||
| 6 | New Leaf Venture Partners, L.L.C. | 658,259 | 17,213,000 | 4.43% | ||
| 7 | Cormorant Asset Management, LP | 507,907 | 13,282,000 | 3.42% | ||
| 8 | DEERFIELD MANAGEMENT COMPANY, L.P. | 472,124 | 12,346,000 | 3.18% | ||
| 9 | EVENTIDE ASSET MANAGEMENT, LLC | 383,630 | 10,032,000 | 2.58% | ||
| 10 | BlackRock Fund Advisors | 239,940 | 6,274,000 | 1.62% | ||
| 11 | CLOUGH CAPITAL PARTNERS L P | 211,103 | 5,520,000 | 1.42% | ||
| 12 | VANGUARD GROUP INC | 146,231 | 3,824,000 | 0.98% | ||
| 13 | PRICE T ROWE ASSOCIATES INC /MD/ | 142,220 | 3,719,000 | 0.96% | ||
| 14 | STATE STREET CORP | 115,167 | 3,011,000 | 0.78% | ||
| 15 | NORTHERN TRUST CORP | 97,521 | 2,549,000 | 0.66% | ||
| 16 | JENNISON ASSOCIATES LLC | 75,435 | 1,973,000 | 0.51% | ||
| 17 | GEODE CAPITAL MANAGEMENT, LLC | 73,081 | 1,911,000 | 0.49% | ||
| 18 | BlackRock Institutional Trust Company, N.A. | 63,815 | 1,669,000 | 0.43% | ||
| 19 | EMORY UNIVERSITY | 56,074 | 1,466,000 | 0.38% | ||
| 20 | Bank of New York Mellon Corp | 31,071 | 813,000 | 0.21% | ||
| 21 | MARSHALL WACE, LLP | 29,822 | 780,000 | 0.20% | ||
| 22 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 28,826 | 754,000 | 0.19% | ||
| 23 | BlackRock Investment Management, LLC | 28,121 | 735,000 | 0.19% | ||
| 24 | MORGAN STANLEY | 23,181 | 606,000 | 0.16% | ||
| 25 | TIAA CREF INVESTMENT MANAGEMENT LLC | 21,039 | 550,000 | 0.14% | ||
| 26 | RENAISSANCE TECHNOLOGIES LLC | 15,400 | 403,000 | 0.10% | ||
| 27 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 15,209 | 398,000 | 0.10% | ||
| 28 | TEACHERS ADVISORS, LLC | 13,088 | 342,000 | 0.09% | ||
| 29 | Swiss National Bank | 11,500 | 301,000 | 0.08% | ||
| 30 | JPMORGAN CHASE & CO | 10,586 | 277,000 | 0.07% | ||
| 31 | DESCHUTES PORTFOLIO STRATEGY, LLC | 10,331 | 270,000 | 0.07% | ||
| 32 | CREDIT SUISSE AG/ | 8,738 | 229,000 | 0.06% | ||
| 33 | NEW YORK STATE COMMON RETIREMENT FUND | 7,700 | 201,000 | 0.05% | ||
| 34 | WELLS FARGO & COMPANY/MN | 6,651 | 174,000 | 0.04% | ||
| 35 | STRS OHIO | 6,000 | 156,000 | 0.04% | ||
| 36 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 4,954 | 130,000 | 0.03% | ||
| 37 | DEUTSCHE BANK AG\ | 4,999 | 129,000 | 0.03% | ||
| 38 | Nationwide Fund Advisors | 4,661 | 122,000 | 0.03% | ||
| 39 | UBS Group AG | 4,528 | 118,000 | 0.03% | ||
| 40 | AMERICAN INTERNATIONAL GROUP, INC. | 4,252 | 111,000 | 0.03% | ||
| 41 | BLACKROCK ADVISORS LLC | 4,262 | 111,000 | 0.03% | ||
| 42 | Legal & General Group Plc | 2,532 | 68,000 | 0.02% | ||
| 43 | CITIGROUP INC | 2,322 | 61,000 | 0.02% | ||
| 44 | BANK OF AMERICA CORP /DE/ | 1,017 | 27,000 | 0.01% | ||
| 45 | Tower Research Capital LLC (TRC) | 928 | 24,000 | 0.01% | ||
| 46 | ROYAL BANK OF CANADA | 768 | 20,000 | 0.01% | ||
| 47 | PRENTISS SMITH & CO INC | 500 | 13,000 | 0.00% | ||
| 48 | BNP PARIBAS FINANCIAL MARKETS | 444 | 11,611 | 0.00% | ||
| 49 | BlackRock Finance, Inc. | 373 | 10,000 | 0.00% | ||
| 50 | BARCLAYS PLC | 298 | 9,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
