| 1 |
FMR LLC |
2,762,011 |
9,391,000 |
23.76% |
|
|
| 2 |
RA CAPITAL MANAGEMENT, L.P. |
2,428,571 |
8,257,000 |
20.89% |
|
|
| 3 |
RTW INVESTMENTS, LP |
2,062,991 |
7,014,000 |
17.74% |
|
|
| 4 |
683 Capital Management, LLC |
800,000 |
2,720,000 |
6.88% |
|
|
| 5 |
Palo Alto Investors LP |
481,519 |
1,637,000 |
4.14% |
|
|
| 6 |
RENAISSANCE TECHNOLOGIES LLC |
418,500 |
1,423,000 |
3.60% |
|
|
| 7 |
EcoR1 Capital, LLC |
382,000 |
1,299,000 |
3.29% |
|
|
| 8 |
EVENTIDE ASSET MANAGEMENT, LLC |
377,000 |
1,282,000 |
3.24% |
|
|
| 9 |
VANGUARD GROUP INC |
325,810 |
1,108,000 |
2.80% |
|
|
| 10 |
UBS Group AG |
284,645 |
968,000 |
2.45% |
|
|
| 11 |
Omega Fund Management, LLC |
223,457 |
760,000 |
1.92% |
|
|
| 12 |
SABBY MANAGEMENT, LLC |
200,000 |
680,000 |
1.72% |
|
|
| 13 |
Paloma Partners Management Co |
160,000 |
544,000 |
1.38% |
|
|
| 14 |
BlackRock Finance, Inc. |
130,453 |
443,000 |
1.12% |
|
|
| 15 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
93,300 |
317,000 |
0.80% |
|
|
| 16 |
GEODE CAPITAL MANAGEMENT, LLC |
85,950 |
292,000 |
0.74% |
|
|
| 17 |
Connor, Clark & Lunn Investment Management Ltd. |
61,700 |
210,000 |
0.53% |
|
|
| 18 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
41,000 |
139,000 |
0.35% |
|
|
| 19 |
DIMENSIONAL FUND ADVISORS LP |
36,978 |
126,000 |
0.32% |
|
|
| 20 |
NORTHERN TRUST CORP |
34,125 |
116,000 |
0.29% |
|
|
| 21 |
Bank of New York Mellon Corp |
29,119 |
99,000 |
0.25% |
|
|
| 22 |
Virtu KCG Holdings LLC |
28,099 |
96,000 |
0.24% |
|
|
| 23 |
MORGAN STANLEY |
25,769 |
88,000 |
0.22% |
|
|
| 24 |
PDT Partners, LLC |
25,300 |
86,000 |
0.22% |
|
|
| 25 |
BANK OF MONTREAL /CAN/ |
23,000 |
78,000 |
0.20% |
|
|
| 26 |
DEUTSCHE BANK AG\ |
18,500 |
62,000 |
0.16% |
|
|
| 27 |
TFS CAPITAL LLC |
16,204 |
55,000 |
0.14% |
|
|
| 28 |
Quotient Investors, LLC |
13,600 |
46,000 |
0.12% |
|
|
| 29 |
BOURGEON CAPITAL MANAGEMENT LLC |
13,500 |
46,000 |
0.12% |
|
|
| 30 |
R&F CAPITAL ADVISORS LP |
10,020 |
34,000 |
0.09% |
|
|
| 31 |
Creative Planning |
8,000 |
27,000 |
0.07% |
|
|
| 32 |
ACROSPIRE INVESTMENT MANAGEMENT LLC |
6,064 |
21,000 |
0.05% |
|
|
| 33 |
PANAGORA ASSET MANAGEMENT INC |
5,244 |
18,000 |
0.05% |
|
|
| 34 |
Tower Research Capital LLC (TRC) |
4,575 |
16,000 |
0.04% |
|
|
| 35 |
JPMORGAN CHASE & CO |
2,100 |
7,000 |
0.02% |
|
|
| 36 |
Walleye Trading LLC |
1,900 |
6,000 |
0.02% |
|
|
| 37 |
FEDERATED HERMES, INC. |
1,541 |
5,000 |
0.01% |
|
|
| 38 |
PRELUDE CAPITAL MANAGEMENT, LLC |
1,200 |
4,000 |
0.01% |
|
|
| 39 |
QS Investors, LLC |
1,071 |
4,000 |
0.01% |
|
|
| 40 |
CITIGROUP INC |
1,097 |
4,000 |
0.01% |
|
|
| 41 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
671 |
2,000 |
0.01% |
|
|
| 42 |
ACADIAN ASSET MANAGEMENT LLC |
325 |
1,000 |
0.00% |
|
|
| 43 |
BNP PARIBAS FINANCIAL MARKETS |
32 |
109 |
0.00% |
|
|
| 44 |
BARCLAYS PLC |
78 |
0 |
0.00% |
|
|
| 45 |
BANK OF AMERICA CORP /DE/ |
35 |
0 |
0.00% |
|
|
