| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,665,993 | 43,909,000 | 21.49% | ||
| 2 | RA CAPITAL MANAGEMENT, L.P. | 2,428,571 | 39,999,000 | 19.58% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 1,515,302 | 24,957,000 | 12.21% | ||
| 4 | Abingworth LLP | 1,182,196 | 19,423,000 | 9.51% | ||
| 5 | RTW INVESTMENTS, LP | 1,115,981 | 18,380,000 | 9.00% | ||
| 6 | FRANKLIN RESOURCES INC | 595,723 | 9,812,000 | 4.80% | ||
| 7 | Omega Fund Management, LLC | 468,471 | 7,716,000 | 3.78% | ||
| 8 | JPMORGAN CHASE & CO | 303,625 | 5,000,000 | 2.45% | ||
| 9 | TIVERTON ASSET MANAGEMENT LLC | 300,000 | 4,939,000 | 2.42% | ||
| 10 | VANGUARD GROUP INC | 237,794 | 3,916,000 | 1.92% | ||
| 11 | Cormorant Asset Management, LP | 200,000 | 3,294,000 | 1.61% | ||
| 12 | SPHERA FUNDS MANAGEMENT LTD. | 176,802 | 2,912,000 | 1.43% | ||
| 13 | Tekla Capital Management LLC | 156,250 | 2,573,000 | 1.26% | ||
| 14 | SABBY MANAGEMENT, LLC | 145,919 | 2,403,000 | 1.18% | ||
| 15 | Candriam S.C.A. | 110,000 | 1,812,000 | 0.89% | ||
| 16 | BlackRock Fund Advisors | 103,184 | 1,699,000 | 0.83% | ||
| 17 | EVENTIDE ASSET MANAGEMENT, LLC | 83,700 | 1,379,000 | 0.67% | ||
| 18 | AWM Investment Company, Inc. | 80,000 | 1,318,000 | 0.65% | ||
| 19 | STATE STREET CORP | 63,562 | 1,046,000 | 0.51% | ||
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 56,205 | 925,000 | 0.45% | ||
| 21 | NORTHERN TRUST CORP | 48,505 | 799,000 | 0.39% | ||
| 22 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 47,500 | 782,000 | 0.38% | ||
| 23 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 45,000 | 741,000 | 0.36% | ||
| 24 | COMMONWEALTH BANK OF AUSTRALIA | 32,700 | 539,000 | 0.26% | ||
| 25 | EMERALD MUTUAL FUND ADVISERS TRUST | 30,490 | 502,000 | 0.25% | ||
| 26 | BlackRock Institutional Trust Company, N.A. | 30,373 | 500,000 | 0.24% | ||
| 27 | TIAA CREF INVESTMENT MANAGEMENT LLC | 29,452 | 485,000 | 0.24% | ||
| 28 | Bank of New York Mellon Corp | 27,588 | 454,000 | 0.22% | ||
| 29 | BOURGEON CAPITAL MANAGEMENT LLC | 25,000 | 412,000 | 0.20% | ||
| 30 | D. E. Shaw & Co., Inc. | 21,658 | 357,000 | 0.17% | ||
| 31 | Nationwide Fund Advisors | 19,881 | 327,000 | 0.16% | ||
| 32 | MORGAN STANLEY | 11,064 | 182,000 | 0.09% | ||
| 33 | BlackRock Investment Management, LLC | 10,695 | 176,000 | 0.09% | ||
| 34 | Airain ltd | 10,500 | 173,000 | 0.08% | ||
| 35 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 6,565 | 108,000 | 0.05% | ||
| 36 | TEACHERS ADVISORS, LLC | 53,839 | 82,000 | 0.04% | ||
| 37 | CITIGROUP INC | 3,592 | 59,000 | 0.03% | ||
| 38 | BlackRock Group LTD | 3,277 | 54,000 | 0.03% | ||
| 39 | BANK OF AMERICA CORP /DE/ | 3,030 | 50,000 | 0.02% | ||
| 40 | BLACKROCK ADVISORS LLC | 2,541 | 42,000 | 0.02% | ||
| 41 | AMERICAN INTERNATIONAL GROUP, INC. | 2,237 | 36,843 | 0.02% | ||
| 42 | ALLIANCEBERNSTEIN L.P. | 1,300 | 21,000 | 0.01% | ||
| 43 | Tower Research Capital LLC (TRC) | 825 | 14,000 | 0.01% | ||
| 44 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 616 | 10,000 | 0.00% | ||
| 45 | BARCLAYS PLC | 203 | 3,000 | 0.00% | ||
| 46 | WELLS FARGO & COMPANY/MN | 165 | 3,000 | 0.00% | ||
| 47 | ROYAL BANK OF CANADA | 2 | 0 | 0.00% | ||
| 48 | DEUTSCHE BANK AG\ | 2 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
