| 1 |
Third Rock Ventures, LLC |
4,841,591 |
53,935,000 |
41.38% |
|
|
| 2 |
Flagship Ventures 2007 General Partner LLC |
1,907,008 |
21,244,000 |
16.30% |
|
|
| 3 |
FMR LLC |
1,823,912 |
20,318,000 |
15.59% |
|
|
| 4 |
Broadfin Capital, LLC |
857,715 |
9,555,000 |
7.33% |
|
|
| 5 |
FRANKLIN RESOURCES INC |
815,171 |
9,081,000 |
6.97% |
|
|
| 6 |
JPMORGAN CHASE & CO |
393,690 |
4,385,000 |
3.36% |
|
|
| 7 |
SECTORAL ASSET MANAGEMENT INC |
112,485 |
1,253,000 |
0.96% |
|
|
| 8 |
C WorldWide Group Holding A/S |
100,000 |
1,161,000 |
0.89% |
|
|
| 9 |
BlackRock Fund Advisors |
98,153 |
1,093,000 |
0.84% |
|
|
| 10 |
PRINCIPAL FINANCIAL GROUP INC |
95,300 |
1,062,000 |
0.81% |
|
|
| 11 |
VANGUARD GROUP INC |
94,482 |
1,052,000 |
0.81% |
|
|
| 12 |
State of New Jersey Common Pension Fund D |
75,000 |
836,000 |
0.64% |
|
|
| 13 |
STATE STREET CORP |
60,746 |
676,000 |
0.52% |
|
|
| 14 |
Point72 Asset Management, L.P. |
55,450 |
618,000 |
0.47% |
|
|
| 15 |
Bank of New York Mellon Corp |
49,605 |
552,000 |
0.42% |
|
|
| 16 |
NORTHERN TRUST CORP |
46,511 |
518,000 |
0.40% |
|
|
| 17 |
TCW GROUP INC |
38,166 |
425,000 |
0.33% |
|
|
| 18 |
BlackRock Institutional Trust Company, N.A. |
37,181 |
414,000 |
0.32% |
|
|
| 19 |
GEODE CAPITAL MANAGEMENT, LLC |
30,810 |
343,000 |
0.26% |
|
|
| 20 |
NJ State Employees Deferred Compensation Plan |
25,000 |
278,000 |
0.21% |
|
|
| 21 |
SABBY MANAGEMENT, LLC |
19,997 |
223,000 |
0.17% |
|
|
| 22 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
17,008 |
189,000 |
0.15% |
|
|
| 23 |
GOLDMAN SACHS GROUP INC |
16,819 |
187,000 |
0.14% |
|
|
| 24 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
16,550 |
184,000 |
0.14% |
|
|
| 25 |
BlackRock Investment Management, LLC |
13,155 |
147,000 |
0.11% |
|
|
| 26 |
BANQUE PICTET & CIE SA |
11,387 |
127,000 |
0.10% |
|
|
| 27 |
Tower Research Capital LLC (TRC) |
9,921 |
111,000 |
0.09% |
|
|
| 28 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
8,448 |
94,000 |
0.07% |
|
|
| 29 |
TEACHERS ADVISORS, LLC |
6,131 |
68,000 |
0.05% |
|
|
| 30 |
Nationwide Fund Advisors |
3,574 |
40,000 |
0.03% |
|
|
| 31 |
AMERICAN INTERNATIONAL GROUP, INC. |
3,245 |
36,149 |
0.03% |
|
|
| 32 |
MORGAN STANLEY |
3,071 |
34,000 |
0.03% |
|
|
| 33 |
BLACKROCK ADVISORS LLC |
1,919 |
21,000 |
0.02% |
|
|
| 34 |
STRS OHIO |
1,700 |
19,000 |
0.01% |
|
|
| 35 |
CITIGROUP INC |
1,256 |
14,000 |
0.01% |
|
|
| 36 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
1,148 |
13,000 |
0.01% |
|
|
| 37 |
WELLS FARGO & COMPANY/MN |
710 |
8,000 |
0.01% |
|
|
| 38 |
BNP PARIBAS FINANCIAL MARKETS |
468 |
5,214 |
0.00% |
|
|
| 39 |
Ground Swell Capital, LLC |
402 |
4,000 |
0.00% |
|
|
| 40 |
ALLIANCEBERNSTEIN L.P. |
300 |
3,000 |
0.00% |
|
|
| 41 |
BARCLAYS PLC |
151 |
2,000 |
0.00% |
|
|
| 42 |
DEUTSCHE BANK AG\ |
37 |
0 |
0.00% |
|
|
