| 1 |
Third Rock Ventures, LLC |
4,841,591 |
43,187,000 |
36.26% |
|
|
| 2 |
Flagship Ventures 2007 General Partner LLC |
1,907,008 |
17,011,000 |
14.28% |
|
|
| 3 |
FMR LLC |
1,765,112 |
15,745,000 |
13.22% |
|
|
| 4 |
Broadfin Capital, LLC |
966,057 |
8,617,000 |
7.24% |
|
|
| 5 |
FRANKLIN RESOURCES INC |
929,900 |
8,295,000 |
6.96% |
|
|
| 6 |
ROYCE & ASSOCIATES LP |
388,600 |
3,466,000 |
2.91% |
|
|
| 7 |
JPMORGAN CHASE & CO |
297,909 |
2,657,000 |
2.23% |
|
|
| 8 |
Redmile Group, LLC |
240,000 |
2,141,000 |
1.80% |
|
|
| 9 |
ASCEND CAPITAL, LLC |
210,000 |
1,874,000 |
1.57% |
|
|
| 10 |
Tekla Capital Management LLC |
195,964 |
1,748,000 |
1.47% |
|
|
| 11 |
EverPoint Asset Management, LLC |
175,000 |
1,561,000 |
1.31% |
|
|
| 12 |
Point72 Asset Management, L.P. |
173,869 |
1,551,000 |
1.30% |
|
|
| 13 |
C WorldWide Group Holding A/S |
167,434 |
1,494,000 |
1.25% |
|
|
| 14 |
BlackRock Fund Advisors |
115,282 |
1,028,000 |
0.86% |
|
|
| 15 |
SECTORAL ASSET MANAGEMENT INC |
112,485 |
1,003,000 |
0.84% |
|
|
| 16 |
VANGUARD GROUP INC |
101,807 |
908,000 |
0.76% |
|
|
| 17 |
PRINCIPAL FINANCIAL GROUP INC |
98,500 |
878,000 |
0.74% |
|
|
| 18 |
SPHERA FUNDS MANAGEMENT LTD. |
87,110 |
777,000 |
0.65% |
|
|
| 19 |
State of New Jersey Common Pension Fund D |
75,000 |
669,000 |
0.56% |
|
|
| 20 |
STATE STREET CORP |
68,436 |
612,000 |
0.51% |
|
|
| 21 |
Bank of New York Mellon Corp |
52,478 |
468,000 |
0.39% |
|
|
| 22 |
NORTHERN TRUST CORP |
49,012 |
437,000 |
0.37% |
|
|
| 23 |
Sarissa Capital Management LP |
41,200 |
368,000 |
0.31% |
|
|
| 24 |
BlackRock Institutional Trust Company, N.A. |
40,276 |
359,000 |
0.30% |
|
|
| 25 |
TCW GROUP INC |
39,766 |
355,000 |
0.30% |
|
|
| 26 |
GEODE CAPITAL MANAGEMENT, LLC |
39,125 |
348,000 |
0.29% |
|
|
| 27 |
Polar Capital LLP |
28,042 |
250,000 |
0.21% |
|
|
| 28 |
NJ State Employees Deferred Compensation Plan |
25,000 |
224,000 |
0.19% |
|
|
| 29 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
18,715 |
167,000 |
0.14% |
|
|
| 30 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
18,066 |
161,000 |
0.14% |
|
|
| 31 |
GOLDMAN SACHS GROUP INC |
15,513 |
138,000 |
0.12% |
|
|
| 32 |
BlackRock Investment Management, LLC |
14,382 |
128,000 |
0.11% |
|
|
| 33 |
BLACKROCK ADVISORS LLC |
10,090 |
90,000 |
0.08% |
|
|
| 34 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
9,384 |
84,000 |
0.07% |
|
|
| 35 |
TEACHERS ADVISORS, LLC |
6,131 |
55,000 |
0.05% |
|
|
| 36 |
BlackRock Japan Co. Ltd |
4,266 |
38,000 |
0.03% |
|
|
| 37 |
Nationwide Fund Advisors |
3,574 |
32,000 |
0.03% |
|
|
| 38 |
MORGAN STANLEY |
3,453 |
31,000 |
0.03% |
|
|
| 39 |
FNY Managed Accounts LLC |
3,300 |
29,436 |
0.02% |
|
|
| 40 |
AMERICAN INTERNATIONAL GROUP, INC. |
3,132 |
27,937 |
0.02% |
|
|
| 41 |
Tower Research Capital LLC (TRC) |
2,818 |
25,000 |
0.02% |
|
|
| 42 |
Cubist Systematic Strategies, LLC |
2,548 |
23,000 |
0.02% |
|
|
| 43 |
BlackRock Group LTD |
1,681 |
15,000 |
0.01% |
|
|
| 44 |
UBS Group AG |
923 |
8,000 |
0.01% |
|
|
| 45 |
CITIGROUP INC |
382 |
4,000 |
0.00% |
|
|
| 46 |
ALLIANCEBERNSTEIN L.P. |
300 |
3,000 |
0.00% |
|
|
| 47 |
WELLS FARGO & COMPANY/MN |
322 |
3,000 |
0.00% |
|
|
| 48 |
BARCLAYS PLC |
145 |
2,000 |
0.00% |
|
|
| 49 |
BNP PARIBAS FINANCIAL MARKETS |
116 |
1,035 |
0.00% |
|
|
| 50 |
STRS OHIO |
0 |
0 |
0.00% |
|
|
