| 1 |
Third Rock Ventures, LLC |
4,841,591 |
13,653,000 |
34.12% |
|
|
| 2 |
FMR LLC |
2,877,394 |
8,114,000 |
20.28% |
|
|
| 3 |
Flagship Ventures 2007 General Partner LLC |
1,907,008 |
5,378,000 |
13.44% |
|
|
| 4 |
FRANKLIN RESOURCES INC |
1,718,799 |
4,847,000 |
12.11% |
|
|
| 5 |
Redmile Group, LLC |
1,261,260 |
3,557,000 |
8.89% |
|
|
| 6 |
ORBIMED ADVISORS LLC |
731,600 |
2,063,000 |
5.16% |
|
|
| 7 |
VANGUARD GROUP INC |
112,732 |
318,000 |
0.79% |
|
|
| 8 |
BLACKROCK ADVISORS LLC |
96,822 |
273,000 |
0.68% |
|
|
| 9 |
State of New Jersey Common Pension Fund D |
75,000 |
212,000 |
0.53% |
|
|
| 10 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
50,000 |
141,000 |
0.35% |
|
|
| 11 |
GEODE CAPITAL MANAGEMENT, LLC |
46,487 |
131,000 |
0.33% |
|
|
| 12 |
NORTHERN TRUST CORP |
43,445 |
122,000 |
0.30% |
|
|
| 13 |
Sarissa Capital Management LP |
41,200 |
116,000 |
0.29% |
|
|
| 14 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
39,626 |
112,000 |
0.28% |
|
|
| 15 |
Bank of New York Mellon Corp |
39,441 |
111,000 |
0.28% |
|
|
| 16 |
GOLDMAN SACHS GROUP INC |
36,468 |
103,000 |
0.26% |
|
|
| 17 |
TWO SIGMA ADVISERS, LP |
34,620 |
98,000 |
0.24% |
|
|
| 18 |
BlackRock Institutional Trust Company, N.A. |
33,252 |
94,000 |
0.23% |
|
|
| 19 |
TWO SIGMA INVESTMENTS, LP |
32,880 |
93,000 |
0.23% |
|
|
| 20 |
BlackRock Group LTD |
28,774 |
81,000 |
0.20% |
|
|
| 21 |
MILLENNIUM MANAGEMENT LLC |
25,966 |
73,000 |
0.18% |
|
|
| 22 |
NJ State Employees Deferred Compensation Plan |
25,000 |
70,000 |
0.17% |
|
|
| 23 |
Connor, Clark & Lunn Investment Management Ltd. |
23,100 |
65,000 |
0.16% |
|
|
| 24 |
MORGAN STANLEY |
15,713 |
44,000 |
0.11% |
|
|
| 25 |
CREDIT SUISSE AG/ |
13,212 |
37,000 |
0.09% |
|
|
| 26 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
12,009 |
34,000 |
0.08% |
|
|
| 27 |
Squarepoint Ops LLC |
11,400 |
32,000 |
0.08% |
|
|
| 28 |
Alpine Global Management, LLC |
3,016 |
9,000 |
0.02% |
|
|
| 29 |
NEW YORK STATE COMMON RETIREMENT FUND |
2,925 |
8,000 |
0.02% |
|
|
| 30 |
Cowen Prime Services LLC |
1,700 |
5,000 |
0.01% |
|
|
| 31 |
BlackRock Investment Management, LLC |
1,793 |
5,000 |
0.01% |
|
|
| 32 |
BlackRock Japan Co. Ltd |
1,465 |
4,000 |
0.01% |
|
|
| 33 |
UBS Group AG |
1,514 |
4,000 |
0.01% |
|
|
| 34 |
Walleye Trading LLC |
1,100 |
3,000 |
0.01% |
|
|
| 35 |
DEUTSCHE BANK AG\ |
760 |
2,000 |
0.00% |
|
|
| 36 |
WELLS FARGO & COMPANY/MN |
799 |
2,000 |
0.00% |
|
|
| 37 |
CITIGROUP INC |
600 |
2,000 |
0.00% |
|
|
| 38 |
ROYAL BANK OF CANADA |
300 |
1,000 |
0.00% |
|
|
| 39 |
AMERICAN INTERNATIONAL GROUP, INC. |
250 |
705 |
0.00% |
|
|
| 40 |
REILLY FINANCIAL ADVISORS, LLC |
100 |
0 |
0.00% |
|
|
| 41 |
BANK OF AMERICA CORP /DE/ |
154 |
0 |
0.00% |
|
|
