| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Third Rock Ventures, LLC | 4,841,591 | 57,518,000 | 36.08% | ||
| 2 | Flagship Ventures 2007 General Partner LLC | 1,907,008 | 22,655,000 | 14.21% | ||
| 3 | FMR LLC | 1,765,112 | 20,970,000 | 13.15% | ||
| 4 | Broadfin Capital, LLC | 966,615 | 11,483,000 | 7.20% | ||
| 5 | FRANKLIN RESOURCES INC | 810,200 | 9,625,000 | 6.04% | ||
| 6 | SABBY MANAGEMENT, LLC | 697,470 | 8,286,000 | 5.20% | ||
| 7 | Tekla Capital Management LLC | 610,200 | 6,524,000 | 4.09% | ||
| 8 | JPMORGAN CHASE & CO | 364,576 | 4,331,000 | 2.72% | ||
| 9 | Redmile Group, LLC | 240,000 | 2,851,000 | 1.79% | ||
| 10 | Point72 Asset Management, L.P. | 173,869 | 2,066,000 | 1.30% | ||
| 11 | BlackRock Fund Advisors | 115,451 | 1,372,000 | 0.86% | ||
| 12 | SECTORAL ASSET MANAGEMENT INC | 112,485 | 1,336,000 | 0.84% | ||
| 13 | PRINCIPAL FINANCIAL GROUP INC | 97,600 | 1,159,000 | 0.73% | ||
| 14 | VANGUARD GROUP INC | 95,057 | 1,130,000 | 0.71% | ||
| 15 | SPHERA FUNDS MANAGEMENT LTD. | 87,110 | 1,035,000 | 0.65% | ||
| 16 | State of New Jersey Common Pension Fund D | 75,000 | 891,000 | 0.56% | ||
| 17 | STATE STREET CORP | 68,206 | 810,000 | 0.51% | ||
| 18 | C WorldWide Group Holding A/S | 67,434 | 801,000 | 0.50% | ||
| 19 | Bank of New York Mellon Corp | 49,268 | 585,000 | 0.37% | ||
| 20 | NORTHERN TRUST CORP | 47,637 | 566,000 | 0.35% | ||
| 21 | TCW GROUP INC | 43,066 | 512,000 | 0.32% | ||
| 22 | Sarissa Capital Management LP | 41,200 | 489,000 | 0.31% | ||
| 23 | BlackRock Institutional Trust Company, N.A. | 35,955 | 427,000 | 0.27% | ||
| 24 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 35,265 | 419,000 | 0.26% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 30,960 | 367,000 | 0.23% | ||
| 26 | NJ State Employees Deferred Compensation Plan | 25,000 | 298,000 | 0.19% | ||
| 27 | TIAA CREF INVESTMENT MANAGEMENT LLC | 18,066 | 215,000 | 0.13% | ||
| 28 | GOLDMAN SACHS GROUP INC | 15,988 | 190,000 | 0.12% | ||
| 29 | BlackRock Investment Management, LLC | 13,068 | 155,000 | 0.10% | ||
| 30 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 8,484 | 101,000 | 0.06% | ||
| 31 | TEACHERS ADVISORS, LLC | 6,131 | 73,000 | 0.05% | ||
| 32 | Nationwide Fund Advisors | 3,574 | 42,000 | 0.03% | ||
| 33 | AMERICAN INTERNATIONAL GROUP, INC. | 3,132 | 37,208 | 0.02% | ||
| 34 | MORGAN STANLEY | 2,803 | 33,000 | 0.02% | ||
| 35 | BLACKROCK ADVISORS LLC | 1,919 | 23,000 | 0.01% | ||
| 36 | CITIGROUP INC | 1,886 | 22,000 | 0.01% | ||
| 37 | STRS OHIO | 1,700 | 20,000 | 0.01% | ||
| 38 | WELLS FARGO & COMPANY/MN | 713 | 9,000 | 0.01% | ||
| 39 | UBS Group AG | 335 | 4,000 | 0.00% | ||
| 40 | ALLIANCEBERNSTEIN L.P. | 300 | 4,000 | 0.00% | ||
| 41 | BARCLAYS PLC | 261 | 3,000 | 0.00% | ||
| 42 | DEUTSCHE BANK AG\ | 2 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
