| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | STATE STREET CORP | 8,380,900 | 31,091,000 | 13.91% | ||
| 2 | BAKER BROS. ADVISORS LP | 6,970,902 | 25,862,000 | 11.57% | ||
| 3 | Broadfin Capital, LLC | 5,663,845 | 21,013,000 | 9.40% | ||
| 4 | PUTNAM INVESTMENTS LLC | 5,507,200 | 20,432,000 | 9.14% | ||
| 5 | FMR LLC | 4,577,970 | 16,984,000 | 7.60% | ||
| 6 | VANGUARD GROUP INC | 3,210,859 | 11,912,000 | 5.33% | ||
| 7 | NATIXIS | 3,148,916 | 11,682,000 | 5.23% | ||
| 8 | BlackRock Fund Advisors | 2,249,292 | 8,345,000 | 3.73% | ||
| 9 | JENNISON ASSOCIATES LLC | 2,157,341 | 8,004,000 | 3.58% | ||
| 10 | DEUTSCHE BANK AG\ | 2,079,469 | 7,712,000 | 3.45% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 1,854,713 | 6,881,000 | 3.08% | ||
| 12 | HealthCor Management, L.P. | 1,335,000 | 4,953,000 | 2.22% | ||
| 13 | Palo Alto Investors LP | 1,226,748 | 4,551,000 | 2.04% | ||
| 14 | JPMORGAN CHASE & CO | 1,141,550 | 4,235,000 | 1.90% | ||
| 15 | Alyeska Investment Group, L.P. | 1,021,607 | 3,790,000 | 1.70% | ||
| 16 | NORTHERN TRUST CORP | 895,809 | 3,323,000 | 1.49% | ||
| 17 | AQR CAPITAL MANAGEMENT LLC | 828,880 | 3,076,000 | 1.38% | ||
| 18 | DIMENSIONAL FUND ADVISORS LP | 591,231 | 2,193,000 | 0.98% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 574,675 | 2,132,000 | 0.95% | ||
| 20 | WALL STREET ASSOCIATES | 500,000 | 1,855,000 | 0.83% | ||
| 21 | VIRTUS CAPITAL ADVISERS, LLC | 484,648 | 1,798,000 | 0.80% | ||
| 22 | Bank of New York Mellon Corp | 406,842 | 1,510,000 | 0.68% | ||
| 23 | GUARDIAN LIFE INSURANCE CO OF AMERICA | 371,759 | 1,379,000 | 0.62% | ||
| 24 | GROUP ONE TRADING LLC | 353,566 | 1,312,000 | 0.59% | ||
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 306,640 | 1,138,000 | 0.51% | ||
| 26 | BlackRock Investment Management, LLC | 305,782 | 1,134,000 | 0.51% | ||
| 27 | TIAA CREF INVESTMENT MANAGEMENT LLC | 299,891 | 1,113,000 | 0.50% | ||
| 28 | Connor, Clark & Lunn Investment Management Ltd. | 260,600 | 967,000 | 0.43% | ||
| 29 | ASCEND CAPITAL, LLC | 249,600 | 925,000 | 0.41% | ||
| 30 | MYCIO WEALTH PARTNERS, LLC | 200,000 | 742,000 | 0.33% | ||
| 31 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 195,900 | 727,000 | 0.33% | ||
| 32 | CREDIT SUISSE AG/ | 187,177 | 695,000 | 0.31% | ||
| 33 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 181,500 | 673,000 | 0.30% | Call | |
| 34 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 178,700 | 663,000 | 0.30% | Put | |
| 35 | GOLDMAN SACHS GROUP INC | 167,293 | 621,000 | 0.28% | ||
| 36 | BANK OF AMERICA CORP /DE/ | 157,505 | 584,000 | 0.26% | ||
| 37 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 156,104 | 579,000 | 0.26% | ||
| 38 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 151,729 | 563,000 | 0.25% | ||
| 39 | TEACHERS ADVISORS, LLC | 125,136 | 464,000 | 0.21% | ||
| 40 | Point72 Asset Management, L.P. | 113,200 | 420,000 | 0.19% | ||
| 41 | PointState Capital LP | 100,000 | 371,000 | 0.17% | ||
| 42 | MILLENNIUM MANAGEMENT LLC | 90,943 | 337,000 | 0.15% | ||
| 43 | NEW YORK STATE COMMON RETIREMENT FUND | 90,023 | 334,000 | 0.15% | ||
| 44 | MORGAN STANLEY | 87,590 | 325,000 | 0.15% | ||
| 45 | LEAVELL INVESTMENT MANAGEMENT, INC. | 81,271 | 302,000 | 0.14% | ||
| 46 | RHUMBLINE ADVISERS | 76,045 | 282,000 | 0.13% | ||
| 47 | BLACKROCK ADVISORS LLC | 58,497 | 217,000 | 0.10% | ||
| 48 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 57,943 | 215,000 | 0.10% | ||
| 49 | BALYASNY ASSET MANAGEMENT L.P. | 56,400 | 209,000 | 0.09% | ||
| 50 | Nationwide Fund Advisors | 56,145 | 208,000 | 0.09% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
