| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 6,965,432 | 25,842,000 | 12.27% | ||
| 2 | STATE STREET CORP | 6,471,069 | 24,007,000 | 11.40% | ||
| 3 | Broadfin Capital, LLC | 5,663,845 | 21,013,000 | 9.98% | ||
| 4 | PUTNAM INVESTMENTS LLC | 5,507,200 | 20,432,000 | 9.70% | ||
| 5 | FMR LLC | 4,575,770 | 16,976,000 | 8.06% | ||
| 6 | NATIXIS | 3,148,916 | 11,682,000 | 5.55% | ||
| 7 | VANGUARD GROUP INC | 3,035,280 | 11,261,000 | 5.35% | ||
| 8 | BlackRock Fund Advisors | 2,428,564 | 9,010,000 | 4.28% | ||
| 9 | JENNISON ASSOCIATES LLC | 2,141,491 | 7,945,000 | 3.77% | ||
| 10 | MILLENNIUM MANAGEMENT LLC | 1,955,464 | 7,255,000 | 3.44% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 1,942,504 | 7,207,000 | 3.42% | ||
| 12 | DEUTSCHE BANK AG\ | 1,889,975 | 7,009,000 | 3.33% | ||
| 13 | Palo Alto Investors LP | 1,170,248 | 4,342,000 | 2.06% | ||
| 14 | HealthCor Management, L.P. | 1,165,786 | 4,325,000 | 2.05% | ||
| 15 | Alyeska Investment Group, L.P. | 1,005,067 | 3,729,000 | 1.77% | ||
| 16 | NORTHERN TRUST CORP | 912,650 | 3,386,000 | 1.61% | ||
| 17 | DIMENSIONAL FUND ADVISORS LP | 771,180 | 2,861,000 | 1.36% | ||
| 18 | AQR CAPITAL MANAGEMENT LLC | 723,721 | 2,685,000 | 1.27% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 542,277 | 2,011,000 | 0.95% | ||
| 20 | WALL STREET ASSOCIATES | 500,000 | 1,855,000 | 0.88% | ||
| 21 | GUARDIAN LIFE INSURANCE CO OF AMERICA | 371,759 | 1,379,000 | 0.65% | ||
| 22 | Connor, Clark & Lunn Investment Management Ltd. | 363,000 | 1,347,000 | 0.64% | ||
| 23 | Bank of New York Mellon Corp | 360,338 | 1,337,000 | 0.63% | ||
| 24 | TIAA CREF INVESTMENT MANAGEMENT LLC | 274,409 | 1,018,000 | 0.48% | ||
| 25 | BlackRock Investment Management, LLC | 250,998 | 931,000 | 0.44% | ||
| 26 | MYCIO WEALTH PARTNERS, LLC | 200,000 | 742,000 | 0.35% | ||
| 27 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 145,900 | 702,000 | 0.33% | ||
| 28 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 156,906 | 582,000 | 0.28% | ||
| 29 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 156,060 | 579,000 | 0.27% | ||
| 30 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 151,729 | 563,000 | 0.27% | ||
| 31 | Point72 Asset Management, L.P. | 137,087 | 509,000 | 0.24% | ||
| 32 | SABBY MANAGEMENT, LLC | 118,000 | 438,000 | 0.21% | ||
| 33 | A.R.T. Advisors, LLC | 117,881 | 437,000 | 0.21% | ||
| 34 | TEACHERS ADVISORS, LLC | 113,117 | 420,000 | 0.20% | ||
| 35 | GROUP ONE TRADING LLC | 109,482 | 406,000 | 0.19% | ||
| 36 | GOLDMAN SACHS GROUP INC | 97,582 | 362,000 | 0.17% | ||
| 37 | LEAVELL INVESTMENT MANAGEMENT, INC. | 81,271 | 302,000 | 0.14% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 79,000 | 293,000 | 0.14% | Put | |
| 39 | RHUMBLINE ADVISERS | 74,745 | 277,000 | 0.13% | ||
| 40 | CREDIT SUISSE AG/ | 72,675 | 270,000 | 0.13% | ||
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 66,800 | 248,000 | 0.12% | Call | |
| 42 | BLACKROCK ADVISORS LLC | 55,395 | 206,000 | 0.10% | ||
| 43 | Nationwide Fund Advisors | 50,641 | 188,000 | 0.09% | ||
| 44 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 49,447 | 184,000 | 0.09% | ||
| 45 | ALLIANCEBERNSTEIN L.P. | 39,500 | 147,000 | 0.07% | ||
| 46 | LMR Partners LLP | 39,042 | 144,000 | 0.07% | ||
| 47 | D. E. Shaw & Co., Inc. | 38,853 | 144,000 | 0.07% | ||
| 48 | AMERICAN INTERNATIONAL GROUP, INC. | 37,858 | 140,453 | 0.07% | ||
| 49 | CARL DOMINO INC | 37,137 | 138,000 | 0.07% | ||
| 50 | Tower Research Capital LLC (TRC) | 36,590 | 136,000 | 0.06% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
