| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 10,272,314 | 15,408,000 | 21.16% | ||
| 2 | VANGUARD GROUP INC | 4,847,505 | 7,271,000 | 9.99% | ||
| 3 | Broadfin Capital, LLC | 4,427,745 | 6,642,000 | 9.12% | ||
| 4 | BlackRock Fund Advisors | 3,292,962 | 4,939,000 | 6.78% | ||
| 5 | NATIXIS | 3,152,583 | 4,729,000 | 6.49% | ||
| 6 | JPMORGAN CHASE & CO | 2,966,625 | 4,450,000 | 6.11% | ||
| 7 | BlackRock Institutional Trust Company, N.A. | 2,555,909 | 3,834,000 | 5.27% | ||
| 8 | FMR LLC | 2,511,700 | 3,768,000 | 5.18% | ||
| 9 | RA CAPITAL MANAGEMENT, L.P. | 2,250,000 | 3,375,000 | 4.64% | ||
| 10 | STATE STREET CORP | 1,553,323 | 2,330,000 | 3.20% | ||
| 11 | NORTHERN TRUST CORP | 1,118,634 | 1,678,000 | 2.30% | ||
| 12 | Alyeska Investment Group, L.P. | 1,091,104 | 1,637,000 | 2.25% | ||
| 13 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,013,164 | 1,520,000 | 2.09% | ||
| 14 | GEODE CAPITAL MANAGEMENT, LLC | 867,504 | 1,301,000 | 1.79% | ||
| 15 | Palo Alto Investors LP | 616,355 | 925,000 | 1.27% | ||
| 16 | MILLENNIUM MANAGEMENT LLC | 463,024 | 695,000 | 0.95% | ||
| 17 | Laurion Capital Management LP | 397,335 | 596,000 | 0.82% | ||
| 18 | BlackRock Investment Management, LLC | 367,938 | 552,000 | 0.76% | ||
| 19 | Bank of New York Mellon Corp | 354,520 | 532,000 | 0.73% | ||
| 20 | MORGAN STANLEY | 316,278 | 475,000 | 0.65% | ||
| 21 | NORGES BANK | 300,000 | 450,000 | 0.62% | ||
| 22 | TIAA CREF INVESTMENT MANAGEMENT LLC | 293,026 | 440,000 | 0.60% | ||
| 23 | MYCIO WEALTH PARTNERS, LLC | 246,527 | 370,000 | 0.51% | ||
| 24 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 213,393 | 320,000 | 0.44% | ||
| 25 | Creative Planning | 210,213 | 315,000 | 0.43% | ||
| 26 | GROUP ONE TRADING LLC | 203,450 | 305,000 | 0.42% | ||
| 27 | D. E. Shaw & Co., Inc. | 183,608 | 275,000 | 0.38% | ||
| 28 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 167,600 | 251,000 | 0.34% | ||
| 29 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 166,529 | 250,000 | 0.34% | ||
| 30 | TEACHERS ADVISORS, LLC | 154,886 | 232,000 | 0.32% | ||
| 31 | CITIGROUP INC | 117,481 | 176,000 | 0.24% | ||
| 32 | WEDBUSH SECURITIES INC | 112,828 | 169,000 | 0.23% | ||
| 33 | Compagnie Lombard Odier SCmA | 110,000 | 165,000 | 0.23% | ||
| 34 | RHUMBLINE ADVISERS | 101,752 | 153,000 | 0.21% | ||
| 35 | WELLS FARGO & COMPANY/MN | 86,479 | 129,000 | 0.18% | ||
| 36 | Virtu KCG Holdings LLC | 84,019 | 126,000 | 0.17% | ||
| 37 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 82,363 | 124,000 | 0.17% | ||
| 38 | LEAVELL INVESTMENT MANAGEMENT, INC. | 81,271 | 122,000 | 0.17% | ||
| 39 | NEW YORK STATE COMMON RETIREMENT FUND | 78,200 | 117,000 | 0.16% | ||
| 40 | ALLIANCEBERNSTEIN L.P. | 77,300 | 116,000 | 0.16% | ||
| 41 | UBS Group AG | 74,134 | 112,000 | 0.15% | ||
| 42 | DEUTSCHE BANK AG\ | 65,156 | 97,000 | 0.13% | ||
| 43 | A.R.T. Advisors, LLC | 60,935 | 91,000 | 0.12% | ||
| 44 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 60,500 | 91,000 | 0.12% | Put | |
| 45 | Nationwide Fund Advisors | 58,157 | 87,000 | 0.12% | ||
| 46 | AMERICAN INTERNATIONAL GROUP, INC. | 51,198 | 77,000 | 0.11% | ||
| 47 | BLACKROCK ADVISORS LLC | 50,453 | 76,000 | 0.10% | ||
| 48 | CREDIT SUISSE AG/ | 45,197 | 68,000 | 0.09% | ||
| 49 | VOYA INVESTMENT MANAGEMENT LLC | 38,826 | 58,000 | 0.08% | ||
| 50 | Commonwealth Equity Services, Inc | 34,600 | 52,000 | 0.07% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
