| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 6,983,107 | 21,578,000 | 14.09% | ||
| 2 | PUTNAM INVESTMENTS LLC | 5,726,674 | 17,695,000 | 11.56% | ||
| 3 | VANGUARD GROUP INC | 3,494,198 | 10,798,000 | 7.05% | ||
| 4 | JPMORGAN CHASE & CO | 3,162,075 | 9,771,000 | 6.38% | ||
| 5 | NATIXIS | 3,148,916 | 9,730,000 | 6.35% | ||
| 6 | Broadfin Capital, LLC | 3,094,745 | 9,563,000 | 6.24% | ||
| 7 | BlackRock Fund Advisors | 2,307,440 | 7,130,000 | 4.66% | ||
| 8 | STIFEL FINANCIAL CORP | 2,230 | 6,980,000 | 4.56% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 2,197,647 | 6,791,000 | 4.43% | ||
| 10 | DEUTSCHE BANK AG\ | 2,149,861 | 6,641,000 | 4.34% | ||
| 11 | FMR LLC | 1,698,521 | 5,248,000 | 3.43% | ||
| 12 | Point72 Asset Management, L.P. | 1,265,100 | 3,909,000 | 2.55% | ||
| 13 | Palo Alto Investors LP | 1,257,748 | 3,886,000 | 2.54% | ||
| 14 | STATE STREET CORP | 1,203,422 | 3,717,000 | 2.43% | ||
| 15 | NORTHERN TRUST CORP | 945,515 | 2,922,000 | 1.91% | ||
| 16 | MARSHALL WACE, LLP | 769,105 | 2,377,000 | 1.55% | ||
| 17 | DRIEHAUS CAPITAL MANAGEMENT LLC | 701,815 | 2,169,000 | 1.42% | ||
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 676,017 | 2,088,000 | 1.36% | ||
| 19 | Alyeska Investment Group, L.P. | 665,936 | 2,058,000 | 1.34% | ||
| 20 | D. E. Shaw & Co., Inc. | 426,390 | 1,318,000 | 0.86% | ||
| 21 | WALL STREET ASSOCIATES | 400,000 | 1,236,000 | 0.81% | ||
| 22 | GUARDIAN LIFE INSURANCE CO OF AMERICA | 371,759 | 1,149,000 | 0.75% | ||
| 23 | Bank of New York Mellon Corp | 344,664 | 1,065,000 | 0.70% | ||
| 24 | BlackRock Investment Management, LLC | 307,084 | 949,000 | 0.62% | ||
| 25 | TIAA CREF INVESTMENT MANAGEMENT LLC | 284,965 | 881,000 | 0.58% | ||
| 26 | DIMENSIONAL FUND ADVISORS LP | 262,614 | 811,000 | 0.53% | ||
| 27 | OXFORD ASSET MANAGEMENT LLP | 254,582 | 792,000 | 0.52% | ||
| 28 | MYCIO WEALTH PARTNERS, LLC | 200,000 | 618,000 | 0.40% | ||
| 29 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 195,900 | 605,000 | 0.40% | ||
| 30 | VIRTUS CAPITAL ADVISERS, LLC | 192,844 | 596,000 | 0.39% | ||
| 31 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 158,365 | 489,000 | 0.32% | ||
| 32 | CITADEL ADVISORS LLC | 143,499 | 443,000 | 0.29% | ||
| 33 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 138,700 | 429,000 | 0.28% | Call | |
| 34 | Virtu KCG Holdings LLC | 132,571 | 410,000 | 0.27% | ||
| 35 | MACQUARIE GROUP LTD | 131,300 | 406,000 | 0.27% | ||
| 36 | GROUP ONE TRADING LLC | 125,858 | 389,000 | 0.25% | ||
| 37 | TEACHERS ADVISORS, LLC | 125,136 | 387,000 | 0.25% | ||
| 38 | CREDIT SUISSE AG/ | 116,480 | 360,000 | 0.24% | ||
| 39 | Creative Planning | 116,500 | 360,000 | 0.24% | ||
| 40 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 111,929 | 346,000 | 0.23% | ||
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 98,200 | 303,000 | 0.20% | Put | |
| 42 | RHUMBLINE ADVISERS | 86,309 | 267,000 | 0.17% | ||
| 43 | LEAVELL INVESTMENT MANAGEMENT, INC. | 81,271 | 251,000 | 0.16% | ||
| 44 | NEW YORK STATE COMMON RETIREMENT FUND | 78,200 | 242,000 | 0.16% | ||
| 45 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 68,455 | 212,000 | 0.14% | ||
| 46 | METROPOLITAN LIFE INSURANCE CO/NY | 63,909 | 197,000 | 0.13% | ||
| 47 | AMERICAN INTERNATIONAL GROUP, INC. | 61,061 | 189,000 | 0.12% | ||
| 48 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 60,856 | 188,000 | 0.12% | ||
| 49 | ALLIANCEBERNSTEIN L.P. | 55,600 | 186,000 | 0.12% | ||
| 50 | Nationwide Fund Advisors | 58,157 | 180,000 | 0.12% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
