| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 6,990,189 | 13,841,000 | 17.08% | ||
| 2 | PUTNAM INVESTMENTS LLC | 4,179,480 | 8,276,000 | 10.22% | ||
| 3 | VANGUARD GROUP INC | 3,666,124 | 7,259,000 | 8.96% | ||
| 4 | JPMORGAN CHASE & CO | 3,349,700 | 6,632,000 | 8.19% | ||
| 5 | NATIXIS | 3,148,916 | 6,235,000 | 7.70% | ||
| 6 | Broadfin Capital, LLC | 3,094,745 | 6,128,000 | 7.56% | ||
| 7 | BlackRock Fund Advisors | 2,235,490 | 4,426,000 | 5.46% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 2,181,897 | 4,320,000 | 5.33% | ||
| 9 | FMR LLC | 1,899,021 | 3,760,000 | 4.64% | ||
| 10 | Palo Alto Investors LP | 1,257,748 | 2,490,000 | 3.07% | ||
| 11 | STATE STREET CORP | 1,203,168 | 2,380,000 | 2.94% | ||
| 12 | NORTHERN TRUST CORP | 952,113 | 1,885,000 | 2.33% | ||
| 13 | Alyeska Investment Group, L.P. | 828,620 | 1,641,000 | 2.03% | ||
| 14 | GEODE CAPITAL MANAGEMENT, LLC | 680,280 | 1,346,000 | 1.66% | ||
| 15 | WALL STREET ASSOCIATES | 400,000 | 792,000 | 0.98% | ||
| 16 | GUARDIAN LIFE INSURANCE CO OF AMERICA | 371,759 | 736,000 | 0.91% | ||
| 17 | BlackRock Investment Management, LLC | 311,598 | 617,000 | 0.76% | ||
| 18 | Bank of New York Mellon Corp | 309,168 | 612,000 | 0.76% | ||
| 19 | TIAA CREF INVESTMENT MANAGEMENT LLC | 284,965 | 564,000 | 0.70% | ||
| 20 | MYCIO WEALTH PARTNERS, LLC | 246,527 | 488,000 | 0.60% | ||
| 21 | DIMENSIONAL FUND ADVISORS LP | 245,825 | 487,000 | 0.60% | ||
| 22 | OXFORD ASSET MANAGEMENT LLP | 224,775 | 445,000 | 0.55% | ||
| 23 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 184,700 | 366,000 | 0.45% | ||
| 24 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 183,215 | 363,000 | 0.45% | ||
| 25 | VIRTUS CAPITAL ADVISERS, LLC | 158,539 | 314,000 | 0.39% | ||
| 26 | DEUTSCHE BANK AG\ | 158,548 | 313,000 | 0.39% | ||
| 27 | TEACHERS ADVISORS, LLC | 140,681 | 279,000 | 0.34% | ||
| 28 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 111,929 | 222,000 | 0.27% | ||
| 29 | D. E. Shaw & Co., Inc. | 111,150 | 220,000 | 0.27% | ||
| 30 | Creative Planning | 108,500 | 215,000 | 0.27% | ||
| 31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 101,655 | 201,000 | 0.25% | ||
| 32 | CITIGROUP INC | 95,071 | 188,000 | 0.23% | ||
| 33 | RHUMBLINE ADVISERS | 87,504 | 173,000 | 0.21% | ||
| 34 | LEAVELL INVESTMENT MANAGEMENT, INC. | 81,271 | 161,000 | 0.20% | ||
| 35 | GROUP ONE TRADING LLC | 81,124 | 161,000 | 0.20% | ||
| 36 | NEW YORK STATE COMMON RETIREMENT FUND | 78,200 | 155,000 | 0.19% | ||
| 37 | VIRTUS ETF ADVISERS LLC | 74,038 | 147,000 | 0.18% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 69,900 | 138,000 | 0.17% | Put | |
| 39 | Virtu KCG Holdings LLC | 68,325 | 135,000 | 0.17% | ||
| 40 | AMERICAN INTERNATIONAL GROUP, INC. | 66,061 | 131,000 | 0.16% | ||
| 41 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 61,301 | 118,000 | 0.15% | ||
| 42 | Nationwide Fund Advisors | 58,157 | 115,000 | 0.14% | ||
| 43 | ALLIANCEBERNSTEIN L.P. | 55,600 | 110,000 | 0.14% | ||
| 44 | Raymond James Financial Services Advisors, Inc. | 54,338 | 108,000 | 0.13% | ||
| 45 | TFS CAPITAL LLC | 54,624 | 108,000 | 0.13% | ||
| 46 | BLACKROCK ADVISORS LLC | 40,602 | 80,000 | 0.10% | ||
| 47 | VOYA INVESTMENT MANAGEMENT LLC | 38,826 | 77,000 | 0.10% | ||
| 48 | MORGAN STANLEY | 39,129 | 77,000 | 0.10% | ||
| 49 | GOLDMAN SACHS GROUP INC | 38,521 | 76,000 | 0.09% | ||
| 50 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 36,500 | 72,000 | 0.09% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
