| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 10,286,483 | 25,408,000 | 22.13% | ||
| 2 | BlackRock Finance, Inc. | 6,364,776 | 15,720,000 | 13.69% | ||
| 3 | VANGUARD GROUP INC | 5,007,333 | 12,368,000 | 10.77% | ||
| 4 | Broadfin Capital, LLC | 3,852,945 | 9,517,000 | 8.29% | ||
| 5 | FMR LLC | 3,154,462 | 7,792,000 | 6.79% | ||
| 6 | NATIXIS | 3,152,658 | 7,787,000 | 6.78% | ||
| 7 | JPMORGAN CHASE & CO | 2,959,510 | 7,310,000 | 6.37% | ||
| 8 | STATE STREET CORP | 1,582,635 | 3,912,000 | 3.41% | ||
| 9 | NORTHERN TRUST CORP | 1,159,827 | 2,865,000 | 2.50% | ||
| 10 | MILLENNIUM MANAGEMENT LLC | 1,004,119 | 2,480,000 | 2.16% | ||
| 11 | GEODE CAPITAL MANAGEMENT, LLC | 919,446 | 2,271,000 | 1.98% | ||
| 12 | Alyeska Investment Group, L.P. | 878,417 | 2,170,000 | 1.89% | ||
| 13 | Palo Alto Investors LP | 616,355 | 1,522,000 | 1.33% | ||
| 14 | ROYCE & ASSOCIATES LP | 464,490 | 1,147,000 | 1.00% | ||
| 15 | Bank of New York Mellon Corp | 341,393 | 844,000 | 0.74% | ||
| 16 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 322,929 | 798,000 | 0.70% | ||
| 17 | MORGAN STANLEY | 314,550 | 777,000 | 0.68% | ||
| 18 | OXFORD ASSET MANAGEMENT LLP | 300,730 | 743,000 | 0.65% | ||
| 19 | TIAA CREF INVESTMENT MANAGEMENT LLC | 275,586 | 681,000 | 0.59% | ||
| 20 | MYCIO WEALTH PARTNERS, LLC | 246,527 | 609,000 | 0.53% | ||
| 21 | Creative Planning | 204,213 | 504,000 | 0.44% | ||
| 22 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 204,193 | 504,000 | 0.44% | ||
| 23 | D. E. Shaw & Co., Inc. | 181,222 | 448,000 | 0.39% | ||
| 24 | GROUP ONE TRADING LLC | 174,127 | 430,000 | 0.37% | ||
| 25 | TEACHERS ADVISORS, LLC | 169,337 | 418,000 | 0.36% | ||
| 26 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 160,600 | 397,000 | 0.35% | ||
| 27 | Virtu KCG Holdings LLC | 143,471 | 354,000 | 0.31% | ||
| 28 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 126,336 | 312,000 | 0.27% | ||
| 29 | RHUMBLINE ADVISERS | 118,144 | 292,000 | 0.25% | ||
| 30 | Compagnie Lombard Odier SCmA | 110,000 | 272,000 | 0.24% | ||
| 31 | Connor, Clark & Lunn Investment Management Ltd. | 98,350 | 243,000 | 0.21% | ||
| 32 | WELLS FARGO & COMPANY/MN | 91,479 | 226,000 | 0.20% | ||
| 33 | WEDBUSH SECURITIES INC | 90,728 | 224,000 | 0.20% | ||
| 34 | JANE STREET GROUP, LLC | 89,816 | 222,000 | 0.19% | ||
| 35 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 88,660 | 219,000 | 0.19% | ||
| 36 | LEAVELL INVESTMENT MANAGEMENT, INC. | 81,271 | 201,000 | 0.18% | ||
| 37 | NEW YORK STATE COMMON RETIREMENT FUND | 78,201 | 193,000 | 0.17% | ||
| 38 | ALLIANCEBERNSTEIN L.P. | 77,300 | 191,000 | 0.17% | ||
| 39 | CITADEL ADVISORS LLC | 71,892 | 177,000 | 0.15% | ||
| 40 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 67,300 | 166,000 | 0.14% | Put | |
| 41 | Nationwide Fund Advisors | 62,392 | 154,000 | 0.13% | ||
| 42 | AMERICAN INTERNATIONAL GROUP, INC. | 55,412 | 137,000 | 0.12% | ||
| 43 | UBS Group AG | 44,476 | 110,000 | 0.10% | ||
| 44 | TFS CAPITAL LLC | 44,275 | 109,000 | 0.09% | ||
| 45 | TUDOR INVESTMENT CORP ET AL | 41,360 | 102,000 | 0.09% | ||
| 46 | GOLDMAN SACHS GROUP INC | 40,176 | 99,000 | 0.09% | ||
| 47 | VOYA INVESTMENT MANAGEMENT LLC | 38,826 | 96,000 | 0.08% | ||
| 48 | Commonwealth Equity Services, Inc | 35,100 | 87,000 | 0.08% | ||
| 49 | GUGGENHEIM CAPITAL LLC | 31,691 | 78,000 | 0.07% | ||
| 50 | Legal & General Group Plc | 29,020 | 72,000 | 0.06% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
