| 1 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
1,691,857 |
5,668,000 |
17.65% |
|
|
| 2 |
GREAT POINT PARTNERS LLC |
1,369,237 |
4,587,000 |
14.28% |
|
|
| 3 |
ORBIMED ADVISORS LLC |
932,750 |
3,125,000 |
9.73% |
|
|
| 4 |
FRANKLIN RESOURCES INC |
810,812 |
2,716,000 |
8.46% |
|
|
| 5 |
Broadfin Capital, LLC |
766,329 |
2,567,000 |
7.99% |
|
|
| 6 |
SABBY MANAGEMENT, LLC |
688,037 |
2,305,000 |
7.18% |
|
|
| 7 |
BVF INC/IL |
559,624 |
1,875,000 |
5.84% |
|
|
| 8 |
PERCEPTIVE ADVISORS LLC |
478,456 |
1,603,000 |
4.99% |
|
|
| 9 |
VANGUARD GROUP INC |
428,046 |
1,434,000 |
4.46% |
|
|
| 10 |
BlackRock Institutional Trust Company, N.A. |
349,680 |
1,171,000 |
3.65% |
|
|
| 11 |
SECTORAL ASSET MANAGEMENT INC |
221,462 |
742,000 |
2.31% |
|
|
| 12 |
Weiss Multi-Strategy Advisers LLC |
210,000 |
704,000 |
2.19% |
|
|
| 13 |
MOORE CAPITAL MANAGEMENT, LP |
200,000 |
670,000 |
2.09% |
|
|
| 14 |
DEUTSCHE BANK AG\ |
157,648 |
528,000 |
1.64% |
|
|
| 15 |
Rhenman & Partners Asset Management AB |
117,922 |
395,000 |
1.23% |
|
|
| 16 |
RENAISSANCE TECHNOLOGIES LLC |
97,400 |
326,000 |
1.02% |
|
|
| 17 |
KENNEDY CAPITAL MANAGEMENT LLC |
95,767 |
321,000 |
1.00% |
|
|
| 18 |
GEODE CAPITAL MANAGEMENT, LLC |
93,172 |
312,000 |
0.97% |
|
|
| 19 |
PNC FINANCIAL SERVICES GROUP, INC. |
76,000 |
254,000 |
0.79% |
|
|
| 20 |
Jefferies Group LLC |
50,000 |
168,000 |
0.52% |
|
|
| 21 |
NORTHERN TRUST CORP |
37,041 |
124,000 |
0.39% |
|
|
| 22 |
UBS AG |
27,865 |
93,000 |
0.29% |
|
|
| 23 |
SHEPHERD KAPLAN KROCHUK, LLC |
26,000 |
87,000 |
0.27% |
|
|
| 24 |
Rotella Capital Management, Inc. |
21,902 |
73,000 |
0.23% |
|
|
| 25 |
CITIGROUP INC |
17,500 |
59,000 |
0.18% |
|
|
| 26 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
14,600 |
49,000 |
0.15% |
Put |
|
| 27 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
14,600 |
49,000 |
0.15% |
|
|
| 28 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
11,564 |
39,000 |
0.12% |
|
|
| 29 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
11,400 |
38,000 |
0.12% |
Call |
|
| 30 |
BLACKROCK ADVISORS LLC |
6,316 |
21,000 |
0.07% |
|
|
| 31 |
DIMENSIONAL FUND ADVISORS LP |
3,480 |
12,000 |
0.04% |
|
|
| 32 |
GROUP ONE TRADING LLC |
300 |
1,000 |
0.00% |
|
|
| 33 |
BNP PARIBAS FINANCIAL MARKETS |
222 |
628 |
0.00% |
|
|
| 34 |
MORGAN STANLEY |
33 |
0 |
0.00% |
|
|
| 35 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
121 |
0 |
0.00% |
|
|
| 36 |
ROYAL BANK OF CANADA |
7 |
0 |
0.00% |
|
|
