| 1 |
Broadfin Capital, LLC |
1,783,812 |
2,818,000 |
15.72% |
|
|
| 2 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
1,691,857 |
2,673,000 |
14.91% |
|
|
| 3 |
FRANKLIN RESOURCES INC |
1,357,812 |
2,145,000 |
11.97% |
|
|
| 4 |
ProQuest Associates IV LLC |
1,250,000 |
1,975,000 |
11.02% |
|
|
| 5 |
Gruss Capital Management LP |
960,000 |
1,517,000 |
8.46% |
|
|
| 6 |
BVF INC/IL |
559,624 |
884,000 |
4.93% |
|
|
| 7 |
VANGUARD GROUP INC |
550,494 |
869,000 |
4.85% |
|
|
| 8 |
BlackRock Institutional Trust Company, N.A. |
534,756 |
845,000 |
4.71% |
|
|
| 9 |
PERCEPTIVE ADVISORS LLC |
503,156 |
795,000 |
4.44% |
|
|
| 10 |
Abingworth LLP |
437,994 |
679,000 |
3.79% |
|
|
| 11 |
Rhenman & Partners Asset Management AB |
400,000 |
632,000 |
3.53% |
|
|
| 12 |
GREAT POINT PARTNERS LLC |
250,000 |
395,000 |
2.20% |
|
|
| 13 |
Weiss Multi-Strategy Advisers LLC |
210,000 |
332,000 |
1.85% |
|
|
| 14 |
DEUTSCHE BANK AG\ |
203,276 |
321,000 |
1.79% |
|
|
| 15 |
Spark Investment Management LLC |
103,400 |
160,000 |
0.89% |
|
|
| 16 |
KENNEDY CAPITAL MANAGEMENT LLC |
95,143 |
150,000 |
0.84% |
|
|
| 17 |
GEODE CAPITAL MANAGEMENT, LLC |
93,172 |
147,000 |
0.82% |
|
|
| 18 |
HighTower Advisors, LLC |
56,275 |
89,000 |
0.50% |
|
|
| 19 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
46,800 |
74,000 |
0.41% |
|
|
| 20 |
GOLDMAN SACHS GROUP INC |
37,971 |
60,000 |
0.33% |
|
|
| 21 |
NORTHERN TRUST CORP |
36,029 |
57,000 |
0.32% |
|
|
| 22 |
Virtu KCG Holdings LLC |
35,093 |
55,000 |
0.31% |
|
|
| 23 |
CREDIT SUISSE AG/ |
32,003 |
51,000 |
0.28% |
|
|
| 24 |
BlackRock Fund Advisors |
32,423 |
51,000 |
0.28% |
|
|
| 25 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
22,931 |
36,000 |
0.20% |
|
|
| 26 |
CITADEL ADVISORS LLC |
18,538 |
29,000 |
0.16% |
|
|
| 27 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
16,500 |
26,000 |
0.15% |
Put |
|
| 28 |
Rotella Capital Management, Inc. |
15,528 |
25,000 |
0.14% |
|
|
| 29 |
SIMPLEX TRADING, LLC |
5,300 |
8,000 |
0.04% |
|
|
| 30 |
BlackRock Investment Management, LLC |
3,711 |
6,000 |
0.03% |
|
|
| 31 |
LUPO SECURITIES, LLC |
3,725 |
5,886 |
0.03% |
|
|
| 32 |
UBS Group AG |
3,000 |
5,000 |
0.03% |
|
|
| 33 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
2,446 |
4,000 |
0.02% |
|
|
| 34 |
CITIGROUP INC |
1,483 |
2,000 |
0.01% |
|
|
| 35 |
WELLS FARGO & COMPANY/MN |
1,250 |
2,000 |
0.01% |
|
|
| 36 |
PNC FINANCIAL SERVICES GROUP, INC. |
100 |
0 |
0.00% |
|
|
| 37 |
Tower Research Capital LLC (TRC) |
305 |
0 |
0.00% |
|
|
| 38 |
MORGAN STANLEY |
39 |
0 |
0.00% |
|
|
