| 1 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
1,691,857 |
5,735,000 |
17.00% |
|
|
| 2 |
GREAT POINT PARTNERS LLC |
1,500,000 |
5,085,000 |
15.07% |
|
|
| 3 |
FRANKLIN RESOURCES INC |
963,912 |
3,268,000 |
9.68% |
|
|
| 4 |
ORBIMED ADVISORS LLC |
932,750 |
3,162,000 |
9.37% |
|
|
| 5 |
Broadfin Capital, LLC |
766,329 |
2,598,000 |
7.70% |
|
|
| 6 |
BVF INC/IL |
559,624 |
1,897,000 |
5.62% |
|
|
| 7 |
VANGUARD GROUP INC |
470,946 |
1,597,000 |
4.73% |
|
|
| 8 |
SABBY MANAGEMENT, LLC |
448,000 |
1,519,000 |
4.50% |
|
|
| 9 |
Abingworth LLP |
437,994 |
1,485,000 |
4.40% |
|
|
| 10 |
BlackRock Institutional Trust Company, N.A. |
407,297 |
1,381,000 |
4.09% |
|
|
| 11 |
Rhenman & Partners Asset Management AB |
300,000 |
1,017,000 |
3.01% |
|
|
| 12 |
SECTORAL ASSET MANAGEMENT INC |
219,609 |
744,000 |
2.20% |
|
|
| 13 |
Weiss Multi-Strategy Advisers LLC |
210,000 |
712,000 |
2.11% |
|
|
| 14 |
MOORE CAPITAL MANAGEMENT, LP |
200,000 |
678,000 |
2.01% |
|
|
| 15 |
DEUTSCHE BANK AG\ |
153,277 |
519,000 |
1.54% |
|
|
| 16 |
RENAISSANCE TECHNOLOGIES LLC |
124,899 |
423,000 |
1.25% |
|
|
| 17 |
KENNEDY CAPITAL MANAGEMENT LLC |
96,661 |
328,000 |
0.97% |
|
|
| 18 |
GEODE CAPITAL MANAGEMENT, LLC |
93,172 |
315,000 |
0.93% |
|
|
| 19 |
PNC FINANCIAL SERVICES GROUP, INC. |
76,000 |
258,000 |
0.76% |
|
|
| 20 |
Jefferies Group LLC |
50,000 |
170,000 |
0.50% |
|
|
| 21 |
NORTHERN TRUST CORP |
36,124 |
122,000 |
0.36% |
|
|
| 22 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
29,766 |
101,000 |
0.30% |
|
|
| 23 |
Gruss Capital Management LP |
26,562 |
90,000 |
0.27% |
|
|
| 24 |
Rotella Capital Management, Inc. |
26,514 |
90,000 |
0.27% |
|
|
| 25 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
26,400 |
89,000 |
0.26% |
Put |
|
| 26 |
SHEPHERD KAPLAN KROCHUK, LLC |
21,500 |
73,000 |
0.22% |
|
|
| 27 |
UBS AG |
19,096 |
65,000 |
0.19% |
|
|
| 28 |
CITIGROUP INC |
17,753 |
60,000 |
0.18% |
|
|
| 29 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
13,842 |
47,000 |
0.14% |
|
|
| 30 |
GROUP ONE TRADING LLC |
9,650 |
33,000 |
0.10% |
|
|
| 31 |
CITADEL ADVISORS LLC |
9,263 |
31,000 |
0.09% |
|
|
| 32 |
BLACKROCK ADVISORS LLC |
6,316 |
21,000 |
0.06% |
|
|
| 33 |
DIMENSIONAL FUND ADVISORS LP |
3,480 |
12,000 |
0.04% |
|
|
| 34 |
BlackRock Investment Management, LLC |
3,384 |
11,000 |
0.03% |
|
|
| 35 |
Creative Planning |
2,000 |
7,000 |
0.02% |
|
|
| 36 |
BNP PARIBAS FINANCIAL MARKETS |
222 |
753 |
0.00% |
|
|
| 37 |
MORGAN STANLEY |
33 |
0 |
0.00% |
|
|
| 38 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
121 |
0 |
0.00% |
|
|
