| 1 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
1,691,857 |
3,248,000 |
15.78% |
|
|
| 2 |
GREAT POINT PARTNERS LLC |
1,431,196 |
2,748,000 |
13.35% |
|
|
| 3 |
Broadfin Capital, LLC |
1,301,622 |
2,499,000 |
12.14% |
|
|
| 4 |
FRANKLIN RESOURCES INC |
963,912 |
1,851,000 |
8.99% |
|
|
| 5 |
Gruss Capital Management LP |
860,000 |
1,651,000 |
8.02% |
|
|
| 6 |
BVF INC/IL |
559,624 |
1,074,000 |
5.22% |
|
|
| 7 |
BlackRock Institutional Trust Company, N.A. |
530,636 |
1,019,000 |
4.95% |
|
|
| 8 |
VANGUARD GROUP INC |
529,594 |
1,017,000 |
4.94% |
|
|
| 9 |
PERCEPTIVE ADVISORS LLC |
478,456 |
919,000 |
4.46% |
|
|
| 10 |
Abingworth LLP |
437,994 |
832,000 |
4.04% |
|
|
| 11 |
Rhenman & Partners Asset Management AB |
400,000 |
768,000 |
3.73% |
|
|
| 12 |
SECTORAL ASSET MANAGEMENT INC |
247,961 |
476,000 |
2.31% |
|
|
| 13 |
Weiss Multi-Strategy Advisers LLC |
210,000 |
403,000 |
1.96% |
|
|
| 14 |
DEUTSCHE BANK AG\ |
178,277 |
342,000 |
1.66% |
|
|
| 15 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
107,381 |
206,000 |
1.00% |
|
|
| 16 |
Jefferies Group LLC |
100,000 |
192,000 |
0.93% |
|
|
| 17 |
BANK OF AMERICA CORP /DE/ |
100,000 |
192,000 |
0.93% |
|
|
| 18 |
KENNEDY CAPITAL MANAGEMENT LLC |
95,204 |
183,000 |
0.89% |
|
|
| 19 |
GEODE CAPITAL MANAGEMENT, LLC |
93,172 |
178,000 |
0.86% |
|
|
| 20 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
85,842 |
165,000 |
0.80% |
|
|
| 21 |
PNC FINANCIAL SERVICES GROUP, INC. |
76,000 |
146,000 |
0.71% |
|
|
| 22 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
50,100 |
96,000 |
0.47% |
Put |
|
| 23 |
NORTHERN TRUST CORP |
36,029 |
69,000 |
0.34% |
|
|
| 24 |
Spark Investment Management LLC |
36,400 |
69,000 |
0.34% |
|
|
| 25 |
CREDIT SUISSE AG/ |
32,153 |
61,000 |
0.30% |
|
|
| 26 |
RENAISSANCE TECHNOLOGIES LLC |
26,700 |
51,000 |
0.25% |
|
|
| 27 |
CITIGROUP INC |
17,500 |
34,000 |
0.17% |
|
|
| 28 |
BlackRock Fund Advisors |
12,303 |
24,000 |
0.12% |
|
|
| 29 |
TWO SIGMA INVESTMENTS, LP |
12,121 |
23,000 |
0.11% |
|
|
| 30 |
GROUP ONE TRADING LLC |
7,501 |
14,000 |
0.07% |
|
|
| 31 |
CITADEL ADVISORS LLC |
6,247 |
12,000 |
0.06% |
|
|
| 32 |
UBS AG |
4,251 |
8,000 |
0.04% |
|
|
| 33 |
BlackRock Investment Management, LLC |
3,711 |
7,000 |
0.03% |
|
|
| 34 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
2,446 |
5,000 |
0.02% |
|
|
| 35 |
WELLS FARGO & COMPANY/MN |
1,250 |
2,000 |
0.01% |
|
|
| 36 |
MORGAN STANLEY |
38 |
0 |
0.00% |
|
|
