| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FRANKLIN RESOURCES INC | 3,197,712 | 2,076,000 | 19.13% | ||
| 2 | FMR LLC | 1,836,689 | 1,192,000 | 10.98% | ||
| 3 | Abingworth LLP | 861,723 | 1,174,000 | 10.82% | ||
| 4 | VANGUARD GROUP INC | 1,804,729 | 1,171,000 | 10.79% | ||
| 5 | BlackRock Fund Advisors | 1,263,899 | 820,000 | 7.56% | ||
| 6 | BlackRock Institutional Trust Company, N.A. | 866,924 | 563,000 | 5.19% | ||
| 7 | STATE STREET CORP | 681,886 | 445,000 | 4.10% | ||
| 8 | NORTHERN TRUST CORP | 420,007 | 273,000 | 2.52% | ||
| 9 | MILLENNIUM MANAGEMENT LLC | 380,248 | 247,000 | 2.28% | ||
| 10 | Rock Springs Capital Management LP | 380,000 | 247,000 | 2.28% | ||
| 11 | UBS Group AG | 342,088 | 222,000 | 2.05% | ||
| 12 | GEODE CAPITAL MANAGEMENT, LLC | 305,781 | 197,000 | 1.82% | ||
| 13 | Virtu KCG Holdings LLC | 271,239 | 176,000 | 1.62% | ||
| 14 | CITADEL ADVISORS LLC | 237,389 | 154,000 | 1.42% | ||
| 15 | Rhenman & Partners Asset Management AB | 200,000 | 130,000 | 1.20% | ||
| 16 | Bank of New York Mellon Corp | 199,287 | 129,000 | 1.19% | ||
| 17 | R&F CAPITAL ADVISORS LP | 171,205 | 111,000 | 1.02% | ||
| 18 | INTEGRAL DERIVATIVES, LLC | 168,681 | 109,000 | 1.00% | ||
| 19 | BlackRock Investment Management, LLC | 153,309 | 100,000 | 0.92% | ||
| 20 | MORGAN STANLEY | 142,858 | 92,000 | 0.85% | ||
| 21 | TIAA CREF INVESTMENT MANAGEMENT LLC | 126,380 | 82,000 | 0.76% | ||
| 22 | PANAGORA ASSET MANAGEMENT INC | 126,032 | 82,000 | 0.76% | ||
| 23 | D.A. DAVIDSON & CO. | 112,780 | 73,000 | 0.67% | ||
| 24 | CREDIT SUISSE AG/ | 113,432 | 73,000 | 0.67% | ||
| 25 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 102,125 | 66,000 | 0.61% | ||
| 26 | SABBY MANAGEMENT, LLC | 91,055 | 59,000 | 0.54% | ||
| 27 | TEACHERS ADVISORS, LLC | 83,276 | 54,000 | 0.50% | ||
| 28 | GROUP ONE TRADING LLC | 81,056 | 53,000 | 0.49% | ||
| 29 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 80,943 | 53,000 | 0.49% | ||
| 30 | HighTower Advisors, LLC | 73,100 | 49,000 | 0.45% | ||
| 31 | BVF INC/IL | 62,292 | 40,000 | 0.37% | ||
| 32 | Weiss Multi-Strategy Advisers LLC | 58,500 | 38,000 | 0.35% | ||
| 33 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 56,177 | 36,000 | 0.33% | ||
| 34 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 51,939 | 34,000 | 0.31% | ||
| 35 | GLG Partners LP | 40,000 | 26,000 | 0.24% | ||
| 36 | NEW YORK STATE COMMON RETIREMENT FUND | 38,000 | 25,000 | 0.23% | ||
| 37 | CITIGROUP INC | 38,352 | 25,000 | 0.23% | ||
| 38 | Tower Research Capital LLC (TRC) | 36,413 | 24,000 | 0.22% | ||
| 39 | WHITE PINE CAPITAL LLC | 35,000 | 23,000 | 0.21% | ||
| 40 | RHUMBLINE ADVISERS | 34,480 | 22,000 | 0.20% | ||
| 41 | BANK OF AMERICA CORP /DE/ | 30,139 | 19,000 | 0.18% | ||
| 42 | Nationwide Fund Advisors | 25,816 | 17,000 | 0.16% | ||
| 43 | GOLDMAN SACHS GROUP INC | 24,387 | 16,000 | 0.15% | ||
| 44 | AMERICAN INTERNATIONAL GROUP, INC. | 22,616 | 15,000 | 0.14% | ||
| 45 | CITADEL ADVISORS LLC | 23,500 | 15,000 | 0.14% | Put | |
| 46 | ALLIANCEBERNSTEIN L.P. | 21,600 | 14,000 | 0.13% | ||
| 47 | DEUTSCHE BANK AG\ | 22,985 | 14,000 | 0.13% | ||
| 48 | SIMPLEX TRADING, LLC | 22,097 | 14,000 | 0.13% | ||
| 49 | TFS CAPITAL LLC | 19,945 | 13,000 | 0.12% | ||
| 50 | VOYA INVESTMENT MANAGEMENT LLC | 19,647 | 13,000 | 0.12% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
