| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,614,228 | 5,376,000 | 19.66% | ||
| 2 | GREAT POINT PARTNERS LLC | 1,500,000 | 4,995,000 | 18.27% | ||
| 3 | FMR LLC | 1,431,268 | 4,766,000 | 17.43% | ||
| 4 | Artal Group S.A. | 1,000,000 | 3,330,000 | 12.18% | ||
| 5 | FIRST MANHATTAN CO. LLC. | 751,842 | 2,503,000 | 9.15% | ||
| 6 | BVF INC/IL | 600,000 | 1,998,000 | 7.31% | ||
| 7 | FRANKLIN RESOURCES INC | 500,000 | 1,665,000 | 6.09% | ||
| 8 | Palo Alto Investors LP | 292,900 | 975,000 | 3.57% | ||
| 9 | First Eagle Investment Management, LLC | 250,000 | 833,000 | 3.05% | ||
| 10 | SOPHROSYNE CAPITAL LLC | 93,900 | 314,000 | 1.15% | ||
| 11 | DEUTSCHE BANK AG\ | 73,861 | 245,000 | 0.90% | ||
| 12 | TD ASSET MANAGEMENT INC | 58,850 | 196,000 | 0.72% | ||
| 13 | STIFEL FINANCIAL CORP | 14,825 | 49,000 | 0.18% | ||
| 14 | Bank of New York Mellon Corp | 12,500 | 42,000 | 0.15% | ||
| 15 | Baldwin Investment Management, LLC | 10,500 | 35,000 | 0.13% | SH | |
| 16 | Tower Research Capital LLC (TRC) | 1,968 | 7,000 | 0.03% | ||
| 17 | BANK OF MONTREAL /CAN/ | 1,632 | 6,000 | 0.02% | ||
| 18 | CITIGROUP INC | 588 | 2,000 | 0.01% | ||
| 19 | ROYAL BANK OF CANADA | 738 | 2,000 | 0.01% | ||
| 20 | UBS AG | 312 | 1,000 | 0.00% | ||
| 21 | ALLIANCEBERNSTEIN L.P. | 383 | 1,000 | 0.00% | ||
| 22 | MORGAN STANLEY | 227 | 1,000 | 0.00% | ||
| 23 | BANK OF AMERICA CORP /DE/ | 38 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
