| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,609,928 | 4,718,000 | 25.92% | ||
| 2 | GREAT POINT PARTNERS LLC | 1,585,500 | 4,646,000 | 25.52% | ||
| 3 | Artal Group S.A. | 1,000,000 | 2,930,000 | 16.09% | ||
| 4 | BVF INC/IL | 600,000 | 1,758,000 | 9.66% | ||
| 5 | Gruss Capital Management LP | 364,215 | 1,067,000 | 5.86% | ||
| 6 | FIRST MANHATTAN CO. LLC. | 353,686 | 1,036,000 | 5.69% | ||
| 7 | Palo Alto Investors LP | 292,900 | 858,000 | 4.71% | ||
| 8 | First Eagle Investment Management, LLC | 250,000 | 733,000 | 4.03% | ||
| 9 | DEUTSCHE BANK AG\ | 73,861 | 216,000 | 1.19% | ||
| 10 | TD ASSET MANAGEMENT INC | 58,850 | 172,000 | 0.94% | ||
| 11 | Bank of New York Mellon Corp | 14,500 | 42,000 | 0.23% | ||
| 12 | BlackRock Investment Management, LLC | 2,452 | 7,000 | 0.04% | ||
| 13 | UBS AG | 2,128 | 6,000 | 0.03% | ||
| 14 | BANK OF MONTREAL /CAN/ | 1,632 | 5,000 | 0.03% | ||
| 15 | WELLS FARGO & COMPANY/MN | 1,800 | 5,000 | 0.03% | ||
| 16 | CITIGROUP INC | 1,031 | 3,000 | 0.02% | ||
| 17 | ROYAL BANK OF CANADA | 834 | 2,000 | 0.01% | ||
| 18 | Tower Research Capital LLC (TRC) | 501 | 1,000 | 0.01% | ||
| 19 | MORGAN STANLEY | 28 | 0 | 0.00% | ||
| 20 | BARCLAYS PLC | 125 | 0 | 0.00% | ||
| 21 | BANK OF AMERICA CORP /DE/ | 38 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
