| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,613,328 | 3,614,000 | 25.32% | ||
| 2 | GREAT POINT PARTNERS LLC | 1,585,500 | 3,551,000 | 24.87% | ||
| 3 | Artal Group S.A. | 1,000,000 | 2,240,000 | 15.69% | ||
| 4 | FIRST MANHATTAN CO. LLC. | 605,142 | 1,355,000 | 9.49% | ||
| 5 | BVF INC/IL | 600,000 | 1,344,000 | 9.41% | ||
| 6 | Palo Alto Investors LP | 292,900 | 656,000 | 4.60% | ||
| 7 | First Eagle Investment Management, LLC | 250,000 | 560,000 | 3.92% | ||
| 8 | FRANKLIN RESOURCES INC | 184,100 | 412,000 | 2.89% | ||
| 9 | SOPHROSYNE CAPITAL LLC | 93,900 | 211,000 | 1.48% | ||
| 10 | DEUTSCHE BANK AG\ | 73,861 | 165,000 | 1.16% | ||
| 11 | TD ASSET MANAGEMENT INC | 58,850 | 132,000 | 0.92% | ||
| 12 | Bank of New York Mellon Corp | 12,500 | 28,000 | 0.20% | ||
| 13 | BlackRock Investment Management, LLC | 1,503 | 3,000 | 0.02% | ||
| 14 | BANK OF MONTREAL /CAN/ | 1,632 | 3,000 | 0.02% | ||
| 15 | ROYAL BANK OF CANADA | 738 | 2,000 | 0.01% | ||
| 16 | MORGAN STANLEY | 227 | 0 | 0.00% | ||
| 17 | BANK OF AMERICA CORP /DE/ | 38 | 0 | 0.00% | ||
| 18 | Tower Research Capital LLC (TRC) | 100 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
