| 1 |
Clarus Ventures, LLC |
3,959,440 |
59,194,000 |
31.48% |
|
|
| 2 |
Redmile Group, LLC |
1,133,948 |
16,953,000 |
9.02% |
|
|
| 3 |
Visium Asset Management, LP |
615,800 |
9,206,000 |
4.90% |
|
|
| 4 |
RS INVESTMENT MANAGEMENT CO LLC |
589,033 |
8,806,000 |
4.68% |
|
|
| 5 |
Cortina Asset Management, LLC |
552,517 |
8,260,000 |
4.39% |
|
|
| 6 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
454,281 |
6,792,000 |
3.61% |
|
|
| 7 |
SCHRODER INVESTMENT MANAGEMENT GROUP |
415,800 |
6,216,210 |
3.31% |
|
|
| 8 |
THB ASSET MANAGEMENT |
389,500 |
5,823,000 |
3.10% |
|
|
| 9 |
EMERALD MUTUAL FUND ADVISERS TRUST |
368,690 |
5,512,000 |
2.93% |
|
|
| 10 |
MORGAN STANLEY |
363,758 |
5,437,000 |
2.89% |
|
|
| 11 |
EMERALD ADVISERS, LLC |
346,254 |
5,176,000 |
2.75% |
|
|
| 12 |
GILDER GAGNON HOWE & CO LLC |
333,518 |
4,986,000 |
2.65% |
|
|
| 13 |
MILLENNIUM MANAGEMENT LLC |
308,948 |
4,619,000 |
2.46% |
|
|
| 14 |
Cormorant Asset Management, LP |
300,000 |
4,485,000 |
2.39% |
|
|
| 15 |
NEXT CENTURY GROWTH INVESTORS LLC |
287,465 |
4,297,000 |
2.29% |
|
|
| 16 |
BlackRock Fund Advisors |
241,411 |
3,609,000 |
1.92% |
|
|
| 17 |
VANGUARD GROUP INC |
220,906 |
3,303,000 |
1.76% |
|
|
| 18 |
Pier Capital, LLC |
175,652 |
2,626,000 |
1.40% |
|
|
| 19 |
Nicholas Investment Partners, LP |
127,486 |
1,906,000 |
1.01% |
|
|
| 20 |
Informed Momentum Co LLC |
126,495 |
1,891,000 |
1.01% |
|
|
| 21 |
BlackRock Institutional Trust Company, N.A. |
104,133 |
1,557,000 |
0.83% |
|
|
| 22 |
HIGHLAND CAPITAL MANAGEMENT LP |
95,809 |
1,432,000 |
0.76% |
|
|
| 23 |
Numeric Investors LLC |
89,278 |
1,335,000 |
0.71% |
|
|
| 24 |
STATE STREET CORP |
89,001 |
1,330,000 |
0.71% |
|
|
| 25 |
PACIFIC ALTERNATIVE ASSET MANAGEMENT COMPANY, LLC |
72,325 |
1,081,000 |
0.57% |
|
|
| 26 |
Ghost Tree Capital, LLC |
70,000 |
1,047,000 |
0.56% |
|
|
| 27 |
Bank of New York Mellon Corp |
67,492 |
1,009,000 |
0.54% |
|
|
| 28 |
DRIEHAUS CAPITAL MANAGEMENT LLC |
58,746 |
878,000 |
0.47% |
|
|
| 29 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
54,000 |
807,000 |
0.43% |
|
|
| 30 |
Spark Investment Management LLC |
54,000 |
806,000 |
0.43% |
|
|
| 31 |
GEODE CAPITAL MANAGEMENT, LLC |
53,372 |
797,000 |
0.42% |
|
|
| 32 |
TFS CAPITAL LLC |
43,005 |
643,000 |
0.34% |
|
|
| 33 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
38,631 |
578,000 |
0.31% |
|
|
| 34 |
JANE STREET GROUP, LLC |
37,595 |
562,000 |
0.30% |
|
|
| 35 |
PANAGORA ASSET MANAGEMENT INC |
31,575 |
472,000 |
0.25% |
|
|
| 36 |
RUSSELL FRANK CO/ |
36,846 |
453,000 |
0.24% |
|
|
| 37 |
CREDIT SUISSE AG/ |
28,725 |
429,000 |
0.23% |
|
|
| 38 |
BlackRock Investment Management, LLC |
28,430 |
425,000 |
0.23% |
|
|
| 39 |
NORTHERN TRUST CORP |
27,602 |
413,000 |
0.22% |
|
|
| 40 |
GOLDMAN SACHS GROUP INC |
26,329 |
394,000 |
0.21% |
|
|
| 41 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
21,304 |
318,000 |
0.17% |
|
|
| 42 |
Nationwide Fund Advisors |
18,547 |
277,000 |
0.15% |
|
|
| 43 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
18,300 |
274,000 |
0.15% |
|
|
| 44 |
SG Americas Securities, LLC |
15,081 |
225,000 |
0.12% |
|
|
| 45 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
14,700 |
220,000 |
0.12% |
|
|
| 46 |
TEACHERS ADVISORS, LLC |
13,555 |
203,000 |
0.11% |
|
|
| 47 |
Sterling Capital Management LLC |
10,771 |
161,000 |
0.09% |
|
|
| 48 |
MAGEE THOMSON INVESTMENT PARTNERS LLC |
8,167 |
122,000 |
0.06% |
|
|
| 49 |
Cupps Capital Management, LLC |
8,069 |
120,000 |
0.06% |
|
|
| 50 |
AMERICAN INTERNATIONAL GROUP, INC. |
6,572 |
98,251 |
0.05% |
|
|
