| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Clarus Ventures, LLC | 3,959,440 | 88,296,000 | 20.25% | ||
| 2 | CADIAN CAPITAL MANAGEMENT, LP | 1,985,592 | 44,279,000 | 10.15% | ||
| 3 | MORGAN STANLEY | 1,638,191 | 36,532,000 | 8.38% | ||
| 4 | Redmile Group, LLC | 937,957 | 20,916,000 | 4.80% | ||
| 5 | JENNISON ASSOCIATES LLC | 857,954 | 19,132,000 | 4.39% | ||
| 6 | BlackRock Fund Advisors | 771,651 | 17,208,000 | 3.95% | ||
| 7 | Foresite Capital Management II, LLC | 679,033 | 15,142,000 | 3.47% | ||
| 8 | VANGUARD GROUP INC | 573,215 | 12,782,000 | 2.93% | ||
| 9 | WELLINGTON MANAGEMENT GROUP LLP | 476,510 | 10,626,000 | 2.44% | ||
| 10 | LORD, ABBETT & CO. LLC | 467,434 | 10,423,000 | 2.39% | ||
| 11 | DSC Advisors, L.P. | 465,000 | 10,370,000 | 2.38% | ||
| 12 | MILLENNIUM MANAGEMENT LLC | 458,926 | 10,234,000 | 2.35% | ||
| 13 | FORESITE CAPITAL MANAGEMENT III, LLC | 438,133 | 9,770,000 | 2.24% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 341,780 | 7,622,000 | 1.75% | ||
| 15 | HOMESTEAD ADVISERS CORP | 332,000 | 7,404,000 | 1.70% | ||
| 16 | DRIEHAUS CAPITAL MANAGEMENT LLC | 276,447 | 6,165,000 | 1.41% | ||
| 17 | Ghost Tree Capital, LLC | 250,000 | 5,575,000 | 1.28% | ||
| 18 | RENAISSANCE TECHNOLOGIES LLC | 240,200 | 5,356,000 | 1.23% | ||
| 19 | STATE STREET CORP | 223,065 | 4,977,000 | 1.14% | ||
| 20 | NORTHERN TRUST CORP | 204,553 | 4,562,000 | 1.05% | ||
| 21 | Polar Capital LLP | 185,000 | 4,126,000 | 0.95% | ||
| 22 | PURA VIDA INVESTMENTS, LLC | 161,311 | 3,597,000 | 0.82% | ||
| 23 | FRED ALGER MANAGEMENT, LLC | 160,081 | 3,570,000 | 0.82% | ||
| 24 | Spark Investment Management LLC | 151,000 | 3,367,000 | 0.77% | ||
| 25 | Nicholas Investment Partners, LP | 142,465 | 3,175,000 | 0.73% | ||
| 26 | Informed Momentum Co LLC | 140,525 | 3,134,000 | 0.72% | ||
| 27 | DEERFIELD MANAGEMENT COMPANY, L.P. | 139,000 | 3,100,000 | 0.71% | ||
| 28 | NEW YORK STATE COMMON RETIREMENT FUND | 137,588 | 3,068,000 | 0.70% | ||
| 29 | PRICE T ROWE ASSOCIATES INC /MD/ | 134,361 | 2,996,000 | 0.69% | ||
| 30 | SYSTEMATIC FINANCIAL MANAGEMENT LP | 129,430 | 2,886,000 | 0.66% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 122,626 | 2,733,000 | 0.63% | ||
| 32 | First Light Asset Management, LLC | 115,776 | 2,582,000 | 0.59% | ||
| 33 | Lombard Odier Asset Management (USA) Corp | 95,000 | 2,119,000 | 0.49% | ||
| 34 | MARSHALL WACE, LLP | 93,001 | 2,074,000 | 0.48% | ||
| 35 | TWO SIGMA INVESTMENTS, LP | 92,658 | 2,066,000 | 0.47% | ||
| 36 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 91,368 | 2,037,000 | 0.47% | ||
| 37 | Numeric Investors LLC | 88,356 | 1,970,000 | 0.45% | ||
| 38 | Bank of New York Mellon Corp | 87,564 | 1,953,000 | 0.45% | ||
| 39 | CREDIT SUISSE AG/ | 80,636 | 1,798,000 | 0.41% | ||
| 40 | RUSSELL INVESTMENTS GROUP, LTD. | 77,169 | 1,735,000 | 0.40% | ||
| 41 | Granite Investment Partners, LLC | 77,298 | 1,724,000 | 0.40% | ||
| 42 | SCHONFELD STRATEGIC ADVISORS LLC | 75,000 | 1,673,000 | 0.38% | ||
| 43 | D. E. Shaw & Co., Inc. | 74,321 | 1,657,000 | 0.38% | ||
| 44 | PLATINUM INVESTMENT MANAGEMENT LTD | 74,300 | 1,656,000 | 0.38% | ||
| 45 | TIAA CREF INVESTMENT MANAGEMENT LLC | 70,020 | 1,561,000 | 0.36% | ||
| 46 | BLACKROCK ADVISORS LLC | 68,884 | 1,536,000 | 0.35% | ||
| 47 | OXFORD ASSET MANAGEMENT LLP | 67,374 | 1,502,000 | 0.34% | ||
| 48 | ACADIAN ASSET MANAGEMENT LLC | 61,252 | 1,368,000 | 0.31% | ||
| 49 | ESSEX INVESTMENT MANAGEMENT CO LLC | 59,087 | 1,318,000 | 0.30% | ||
| 50 | BlackRock Investment Management, LLC | 57,699 | 1,287,000 | 0.30% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
