| 1 |
Clarus Ventures, LLC |
3,959,440 |
43,316,000 |
29.83% |
|
|
| 2 |
Redmile Group, LLC |
1,453,655 |
15,903,000 |
10.95% |
|
|
| 3 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
1,003,974 |
10,983,000 |
7.56% |
|
|
| 4 |
Cortina Asset Management, LLC |
752,376 |
8,231,000 |
5.67% |
|
|
| 5 |
RS INVESTMENT MANAGEMENT CO LLC |
603,033 |
6,597,000 |
4.54% |
|
|
| 6 |
THB ASSET MANAGEMENT |
502,429 |
5,496,000 |
3.78% |
|
|
| 7 |
MILLENNIUM MANAGEMENT LLC |
441,835 |
4,834,000 |
3.33% |
|
|
| 8 |
EMERALD ADVISERS, LLC |
389,554 |
4,262,000 |
2.94% |
|
|
| 9 |
EMERALD MUTUAL FUND ADVISERS TRUST |
381,417 |
4,173,000 |
2.87% |
|
|
| 10 |
MORGAN STANLEY |
372,874 |
4,079,000 |
2.81% |
|
|
| 11 |
SCHRODER INVESTMENT MANAGEMENT GROUP |
341,200 |
3,732,728 |
2.57% |
|
|
| 12 |
Cormorant Asset Management, LP |
300,000 |
3,282,000 |
2.26% |
|
|
| 13 |
NEXT CENTURY GROWTH INVESTORS LLC |
281,730 |
3,082,000 |
2.12% |
|
|
| 14 |
Pier Capital, LLC |
246,506 |
2,697,000 |
1.86% |
|
|
| 15 |
VANGUARD GROUP INC |
242,291 |
2,651,000 |
1.83% |
|
|
| 16 |
BlackRock Fund Advisors |
231,925 |
2,537,000 |
1.75% |
|
|
| 17 |
TURNER INVESTMENTS LLC |
202,190 |
2,212,000 |
1.52% |
|
|
| 18 |
GILDER GAGNON HOWE & CO LLC |
194,049 |
2,123,000 |
1.46% |
|
|
| 19 |
Nicholas Investment Partners, LP |
149,656 |
1,637,000 |
1.13% |
|
|
| 20 |
Visium Asset Management, LP |
142,300 |
1,557,000 |
1.07% |
|
|
| 21 |
HIGHLAND CAPITAL MANAGEMENT LP |
134,611 |
1,473,000 |
1.01% |
|
|
| 22 |
NORTHERN TRUST CORP |
106,559 |
1,166,000 |
0.80% |
|
|
| 23 |
STATE STREET CORP |
103,261 |
1,130,000 |
0.78% |
|
|
| 24 |
MILLENNIUM MANAGEMENT LLC |
100,000 |
1,094,000 |
0.75% |
Call |
|
| 25 |
Ghost Tree Capital, LLC |
90,000 |
985,000 |
0.68% |
|
|
| 26 |
BlackRock Institutional Trust Company, N.A. |
83,502 |
914,000 |
0.63% |
|
|
| 27 |
Bank of New York Mellon Corp |
72,613 |
795,000 |
0.55% |
|
|
| 28 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
54,000 |
591,000 |
0.41% |
|
|
| 29 |
GEODE CAPITAL MANAGEMENT, LLC |
53,448 |
584,000 |
0.40% |
|
|
| 30 |
PACIFIC ALTERNATIVE ASSET MANAGEMENT COMPANY, LLC |
37,674 |
412,000 |
0.28% |
|
|
| 31 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
36,906 |
404,000 |
0.28% |
|
|
| 32 |
BlackRock Investment Management, LLC |
29,113 |
318,000 |
0.22% |
|
|
| 33 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
25,569 |
280,000 |
0.19% |
|
|
| 34 |
Nationwide Fund Advisors |
18,714 |
205,000 |
0.14% |
|
|
| 35 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
18,405 |
201,000 |
0.14% |
|
|
| 36 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
17,366 |
190,000 |
0.13% |
|
|
| 37 |
ARDSLEY ADVISORY PARTNERS LP |
15,000 |
164,000 |
0.11% |
|
|
| 38 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
14,700 |
161,000 |
0.11% |
|
|
| 39 |
TEACHERS ADVISORS, LLC |
13,555 |
148,000 |
0.10% |
|
|
| 40 |
Sterling Capital Management LLC |
10,771 |
118,000 |
0.08% |
|
|
| 41 |
MAGEE THOMSON INVESTMENT PARTNERS LLC |
8,167 |
89,000 |
0.06% |
|
|
| 42 |
AMERICAN INTERNATIONAL GROUP, INC. |
6,568 |
71,854 |
0.05% |
|
|
| 43 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
5,205 |
57,000 |
0.04% |
|
|
| 44 |
BLACKROCK ADVISORS LLC |
4,272 |
47,000 |
0.03% |
|
|
| 45 |
Fiera Capital (Europe) Ltd. |
4,081 |
45,000 |
0.03% |
|
|
| 46 |
STRS OHIO |
3,400 |
37,000 |
0.03% |
|
|
| 47 |
WealthTrust-Arizona, LLC |
2,700 |
30,000 |
0.02% |
|
|
| 48 |
Tower Research Capital LLC (TRC) |
2,655 |
29,000 |
0.02% |
|
|
| 49 |
WELLS FARGO & COMPANY/MN |
1,462 |
16,000 |
0.01% |
|
|
| 50 |
MANAGED ACCOUNT ADVISORS LLC |
1,390 |
15,000 |
0.01% |
|
|
