| 1 |
Clarus Ventures, LLC |
3,959,440 |
58,243,000 |
26.34% |
|
|
| 2 |
MORGAN STANLEY |
1,585,122 |
23,317,000 |
10.54% |
|
|
| 3 |
Redmile Group, LLC |
1,357,692 |
19,972,000 |
9.03% |
|
|
| 4 |
CADIAN CAPITAL MANAGEMENT, LP |
1,323,102 |
19,463,000 |
8.80% |
|
|
| 5 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
880,622 |
12,954,000 |
5.86% |
|
|
| 6 |
MILLENNIUM MANAGEMENT LLC |
616,820 |
9,073,000 |
4.10% |
|
|
| 7 |
BlackRock Fund Advisors |
585,620 |
8,614,000 |
3.90% |
|
|
| 8 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
500,000 |
7,355,000 |
3.33% |
|
|
| 9 |
Foresite Capital Management II, LLC |
489,486 |
7,200,000 |
3.26% |
|
|
| 10 |
DSC Advisors, L.P. |
465,000 |
6,840,000 |
3.09% |
|
|
| 11 |
Ghost Tree Capital, LLC |
400,000 |
5,884,000 |
2.66% |
|
|
| 12 |
VANGUARD GROUP INC |
384,185 |
5,651,000 |
2.56% |
|
|
| 13 |
Pier Capital, LLC |
215,772 |
3,174,000 |
1.44% |
|
|
| 14 |
BlackRock Institutional Trust Company, N.A. |
192,519 |
2,832,000 |
1.28% |
|
|
| 15 |
STATE STREET CORP |
162,935 |
2,396,000 |
1.08% |
|
|
| 16 |
Nicholas Investment Partners, LP |
159,209 |
2,342,000 |
1.06% |
|
|
| 17 |
GILDER GAGNON HOWE & CO LLC |
153,614 |
2,260,000 |
1.02% |
|
|
| 18 |
NORTHERN TRUST CORP |
148,971 |
2,191,000 |
0.99% |
|
|
| 19 |
Cortina Asset Management, LLC |
148,060 |
2,178,000 |
0.98% |
|
|
| 20 |
Opus Point Partners Management, LLC |
102,200 |
1,503,000 |
0.68% |
|
|
| 21 |
Informed Momentum Co LLC |
97,045 |
1,428,000 |
0.65% |
|
|
| 22 |
Bank of New York Mellon Corp |
92,162 |
1,355,000 |
0.61% |
|
|
| 23 |
Endurant Capital Management LP |
76,311 |
1,123,000 |
0.51% |
|
|
| 24 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
72,700 |
1,069,000 |
0.48% |
|
|
| 25 |
GEODE CAPITAL MANAGEMENT, LLC |
72,141 |
1,061,000 |
0.48% |
|
|
| 26 |
Spark Investment Management LLC |
69,500 |
1,022,000 |
0.46% |
|
|
| 27 |
HIGHLAND CAPITAL MANAGEMENT LP |
63,000 |
927,000 |
0.42% |
|
|
| 28 |
OXFORD ASSET MANAGEMENT LLP |
55,349 |
817,000 |
0.37% |
|
|
| 29 |
BlackRock Investment Management, LLC |
46,697 |
687,000 |
0.31% |
|
|
| 30 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
41,499 |
610,000 |
0.28% |
|
|
| 31 |
Cormorant Asset Management, LP |
40,000 |
588,000 |
0.27% |
|
|
| 32 |
STRS OHIO |
38,800 |
570,000 |
0.26% |
|
|
| 33 |
ESSEX INVESTMENT MANAGEMENT CO LLC |
33,148 |
488,000 |
0.22% |
|
|
| 34 |
MILLENNIUM MANAGEMENT LLC |
30,900 |
455,000 |
0.21% |
Call |
|
| 35 |
D. E. Shaw & Co., Inc. |
29,753 |
438,000 |
0.20% |
|
|
| 36 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
29,000 |
427,000 |
0.19% |
|
|
| 37 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
24,905 |
366,000 |
0.17% |
|
|
| 38 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
24,100 |
355,000 |
0.16% |
|
|
| 39 |
NEW YORK STATE COMMON RETIREMENT FUND |
24,021 |
353,000 |
0.16% |
|
|
| 40 |
A.R.T. Advisors, LLC |
23,886 |
351,000 |
0.16% |
|
|
| 41 |
JENNISON ASSOCIATES LLC |
22,930 |
337,000 |
0.15% |
|
|
| 42 |
Quantitative Systematic Strategies LLC |
22,519 |
331,000 |
0.15% |
|
|
| 43 |
TEACHERS ADVISORS, LLC |
20,431 |
301,000 |
0.14% |
|
|
| 44 |
ProShare Advisors LLC |
17,639 |
259,000 |
0.12% |
|
|
| 45 |
Dynamic Technology Lab Private Ltd |
14,627 |
215,000 |
0.10% |
|
|
| 46 |
RHUMBLINE ADVISERS |
12,662 |
186,000 |
0.08% |
|
|
| 47 |
CREDIT SUISSE AG/ |
11,696 |
172,000 |
0.08% |
|
|
| 48 |
METROPOLITAN LIFE INSURANCE CO/NY |
10,449 |
154,000 |
0.07% |
|
|
| 49 |
NOMURA HOLDINGS INC |
10,200 |
151,000 |
0.07% |
|
|
| 50 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
9,162 |
135,000 |
0.06% |
|
|
