| 1 |
Clarus Ventures, LLC |
3,959,440 |
55,155,000 |
29.29% |
|
|
| 2 |
Redmile Group, LLC |
1,266,538 |
17,643,000 |
9.37% |
|
|
| 3 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
923,378 |
12,863,000 |
6.83% |
|
|
| 4 |
RS INVESTMENT MANAGEMENT CO LLC |
737,210 |
10,269,000 |
5.45% |
|
|
| 5 |
Cortina Asset Management, LLC |
732,564 |
10,205,000 |
5.42% |
|
|
| 6 |
THB ASSET MANAGEMENT |
512,689 |
7,141,000 |
3.79% |
|
|
| 7 |
MILLENNIUM MANAGEMENT LLC |
407,131 |
5,671,000 |
3.01% |
|
|
| 8 |
EMERALD ADVISERS, LLC |
402,463 |
5,606,000 |
2.98% |
|
|
| 9 |
MORGAN STANLEY |
378,661 |
5,276,000 |
2.80% |
|
|
| 10 |
EMERALD MUTUAL FUND ADVISERS TRUST |
356,818 |
4,970,000 |
2.64% |
|
|
| 11 |
GENERAL ELECTRIC CO |
334,974 |
4,666,000 |
2.48% |
|
|
| 12 |
NEXT CENTURY GROWTH INVESTORS LLC |
330,456 |
4,603,000 |
2.44% |
|
|
| 13 |
CADIAN CAPITAL MANAGEMENT, LP |
315,700 |
4,398,000 |
2.34% |
|
|
| 14 |
Cormorant Asset Management, LP |
300,000 |
4,179,000 |
2.22% |
|
|
| 15 |
BlackRock Fund Advisors |
274,523 |
3,824,000 |
2.03% |
|
|
| 16 |
VANGUARD GROUP INC |
251,708 |
3,507,000 |
1.86% |
|
|
| 17 |
Pier Capital, LLC |
240,998 |
3,357,000 |
1.78% |
|
|
| 18 |
ALTRINSIC GLOBAL ADVISORS LLC |
196,711 |
2,740,000 |
1.46% |
|
|
| 19 |
GILDER GAGNON HOWE & CO LLC |
189,627 |
2,642,000 |
1.40% |
|
|
| 20 |
Nicholas Investment Partners, LP |
149,948 |
2,089,000 |
1.11% |
|
|
| 21 |
STATE STREET CORP |
116,581 |
1,622,000 |
0.86% |
|
|
| 22 |
TURNER INVESTMENTS LLC |
115,720 |
1,612,000 |
0.86% |
|
|
| 23 |
NORTHERN TRUST CORP |
103,417 |
1,440,000 |
0.76% |
|
|
| 24 |
MILLENNIUM MANAGEMENT LLC |
100,000 |
1,393,000 |
0.74% |
Call |
|
| 25 |
Ghost Tree Capital, LLC |
90,000 |
1,254,000 |
0.67% |
|
|
| 26 |
Calamos Advisors LLC |
87,037 |
1,212,000 |
0.64% |
|
|
| 27 |
Endurant Capital Management LP |
85,404 |
1,190,000 |
0.63% |
|
|
| 28 |
Bank of New York Mellon Corp |
85,319 |
1,189,000 |
0.63% |
|
|
| 29 |
BlackRock Institutional Trust Company, N.A. |
80,119 |
1,116,000 |
0.59% |
|
|
| 30 |
GEODE CAPITAL MANAGEMENT, LLC |
56,033 |
779,000 |
0.41% |
|
|
| 31 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
35,210 |
490,000 |
0.26% |
|
|
| 32 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
34,000 |
474,000 |
0.25% |
|
|
| 33 |
BlackRock Investment Management, LLC |
29,210 |
407,000 |
0.22% |
|
|
| 34 |
JPMORGAN CHASE & CO |
25,358 |
353,000 |
0.19% |
|
|
| 35 |
ARDSLEY ADVISORY PARTNERS LP |
25,000 |
348,000 |
0.18% |
|
|
| 36 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
25,569 |
329,000 |
0.17% |
|
|
| 37 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
18,484 |
257,000 |
0.14% |
|
|
| 38 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
18,114 |
252,000 |
0.13% |
|
|
| 39 |
Fiera Capital (Europe) Ltd. |
6,389 |
229,000 |
0.12% |
|
|
| 40 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
14,700 |
205,000 |
0.11% |
|
|
| 41 |
Sterling Capital Management LLC |
13,838 |
193,000 |
0.10% |
|
|
| 42 |
TEACHERS ADVISORS, LLC |
13,555 |
189,000 |
0.10% |
|
|
| 43 |
Robert W. Baird & Co. Inc |
12,430 |
173,000 |
0.09% |
|
|
| 44 |
Virtu KCG Holdings LLC |
10,787 |
150,000 |
0.08% |
|
|
| 45 |
MAGEE THOMSON INVESTMENT PARTNERS LLC |
8,167 |
113,000 |
0.06% |
|
|
| 46 |
Nationwide Fund Advisors |
7,714 |
107,000 |
0.06% |
|
|
| 47 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
7,240 |
101,000 |
0.05% |
|
|
| 48 |
AMERICAN INTERNATIONAL GROUP, INC. |
6,317 |
87,996 |
0.05% |
|
|
| 49 |
BLACKROCK ADVISORS LLC |
3,936 |
55,000 |
0.03% |
|
|
| 50 |
WealthTrust-Arizona, LLC |
2,000 |
28,000 |
0.01% |
|
|
