| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Clarus Ventures, LLC | 3,959,440 | 79,110,000 | 22.99% | ||
| 2 | MORGAN STANLEY | 1,568,392 | 31,336,000 | 9.11% | ||
| 3 | CADIAN CAPITAL MANAGEMENT, LP | 1,458,839 | 29,148,000 | 8.47% | ||
| 4 | Redmile Group, LLC | 1,237,435 | 24,724,000 | 7.18% | ||
| 5 | Foresite Capital Management II, LLC | 752,857 | 15,042,000 | 4.37% | ||
| 6 | BlackRock Fund Advisors | 675,769 | 13,502,000 | 3.92% | ||
| 7 | MILLENNIUM MANAGEMENT LLC | 601,384 | 12,016,000 | 3.49% | ||
| 8 | FORESITE CAPITAL MANAGEMENT III, LLC | 485,600 | 9,702,000 | 2.82% | ||
| 9 | DSC Advisors, L.P. | 465,000 | 9,291,000 | 2.70% | ||
| 10 | LORD, ABBETT & CO. LLC | 461,971 | 9,230,000 | 2.68% | ||
| 11 | VANGUARD GROUP INC | 460,118 | 9,194,000 | 2.67% | ||
| 12 | Ghost Tree Capital, LLC | 375,000 | 7,493,000 | 2.18% | ||
| 13 | DRIEHAUS CAPITAL MANAGEMENT LLC | 320,600 | 6,406,000 | 1.86% | ||
| 14 | HOMESTEAD ADVISERS CORP | 272,000 | 5,435,000 | 1.58% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 241,506 | 4,825,000 | 1.40% | ||
| 16 | DEERFIELD MANAGEMENT COMPANY, L.P. | 226,691 | 4,529,000 | 1.32% | ||
| 17 | STATE STREET CORP | 191,154 | 3,819,000 | 1.11% | ||
| 18 | NORTHERN TRUST CORP | 187,052 | 3,737,000 | 1.09% | ||
| 19 | Nicholas Investment Partners, LP | 160,472 | 3,206,000 | 0.93% | ||
| 20 | Informed Momentum Co LLC | 146,221 | 2,921,000 | 0.85% | ||
| 21 | Penn Capital Management Company, LLC | 141,522 | 2,828,000 | 0.82% | ||
| 22 | PRICE T ROWE ASSOCIATES INC /MD/ | 134,361 | 2,685,000 | 0.78% | ||
| 23 | First Light Asset Management, LLC | 115,860 | 2,315,000 | 0.67% | ||
| 24 | RENAISSANCE TECHNOLOGIES LLC | 113,700 | 2,272,000 | 0.66% | ||
| 25 | Spark Investment Management LLC | 113,300 | 2,263,000 | 0.66% | ||
| 26 | NEW YORK STATE COMMON RETIREMENT FUND | 111,378 | 2,225,000 | 0.65% | ||
| 27 | Granite Investment Partners, LLC | 109,198 | 2,181,000 | 0.63% | ||
| 28 | D. E. Shaw & Co., Inc. | 107,019 | 2,138,000 | 0.62% | ||
| 29 | ESSEX INVESTMENT MANAGEMENT CO LLC | 105,406 | 2,106,000 | 0.61% | ||
| 30 | SYSTEMATIC FINANCIAL MANAGEMENT LP | 104,545 | 2,089,000 | 0.61% | ||
| 31 | Bank of New York Mellon Corp | 98,526 | 1,969,000 | 0.57% | ||
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 98,462 | 1,966,000 | 0.57% | ||
| 33 | PURA VIDA INVESTMENTS, LLC | 96,986 | 1,938,000 | 0.56% | ||
| 34 | Polar Capital LLP | 81,000 | 1,618,000 | 0.47% | ||
| 35 | EMERALD ACQUISITION LTD. | 77,403 | 1,546,000 | 0.45% | ||
| 36 | GILDER GAGNON HOWE & CO LLC | 75,977 | 1,518,000 | 0.44% | ||
| 37 | PLATINUM INVESTMENT MANAGEMENT LTD | 74,300 | 1,484,000 | 0.43% | ||
| 38 | ACADIAN ASSET MANAGEMENT LLC | 70,872 | 1,416,000 | 0.41% | ||
| 39 | Endurant Capital Management LP | 69,574 | 1,390,000 | 0.40% | ||
| 40 | LEVIN CAPITAL STRATEGIES, L.P. | 65,442 | 1,307,000 | 0.38% | ||
| 41 | TIAA CREF INVESTMENT MANAGEMENT LLC | 64,010 | 1,279,000 | 0.37% | ||
| 42 | BlackRock Investment Management, LLC | 57,415 | 1,147,000 | 0.33% | ||
| 43 | FRED ALGER MANAGEMENT, LLC | 47,500 | 949,000 | 0.28% | ||
| 44 | CITADEL ADVISORS LLC | 45,845 | 916,000 | 0.27% | ||
| 45 | TWO SIGMA INVESTMENTS, LP | 41,402 | 827,000 | 0.24% | ||
| 46 | Cormorant Asset Management, LP | 40,490 | 809,000 | 0.24% | ||
| 47 | VICTORY CAPITAL MANAGEMENT INC | 38,190 | 763,000 | 0.22% | ||
| 48 | STRS OHIO | 32,700 | 653,000 | 0.19% | ||
| 49 | DEUTSCHE BANK AG\ | 32,223 | 643,000 | 0.19% | ||
| 50 | Weiss Multi-Strategy Advisers LLC | 32,000 | 639,000 | 0.19% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
