| 1 |
Palo Alto Investors LP |
3,634,984 |
28,680,000 |
16.99% |
|
|
| 2 |
Polaris Venture Management Co IV LLC |
3,148,355 |
24,841,000 |
14.72% |
|
|
| 3 |
COLUMBIA WANGER ASSET MANAGEMENT LLC |
3,016,280 |
23,798,000 |
14.10% |
|
|
| 4 |
NORTH RUN CAPITAL, LP |
1,615,569 |
12,747,000 |
7.55% |
|
|
| 5 |
ORBIMED ADVISORS LLC |
1,500,000 |
11,835,000 |
7.01% |
|
|
| 6 |
GREAT POINT PARTNERS LLC |
1,500,000 |
11,835,000 |
7.01% |
|
|
| 7 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
1,311,290 |
10,346,000 |
6.13% |
|
|
| 8 |
RA CAPITAL MANAGEMENT, L.P. |
666,667 |
5,260,000 |
3.12% |
|
|
| 9 |
SABBY MANAGEMENT, LLC |
500,000 |
3,945,000 |
2.34% |
|
|
| 10 |
BlackRock Fund Advisors |
490,049 |
3,866,000 |
2.29% |
|
|
| 11 |
VANGUARD GROUP INC |
437,933 |
3,455,000 |
2.05% |
|
|
| 12 |
MORGAN STANLEY |
368,479 |
2,908,000 |
1.72% |
|
|
| 13 |
Invesco Ltd. |
361,069 |
2,849,000 |
1.69% |
|
|
| 14 |
Informed Momentum Co LLC |
257,294 |
2,030,000 |
1.20% |
|
|
| 15 |
Alyeska Investment Group, L.P. |
231,250 |
1,824,000 |
1.08% |
|
|
| 16 |
MILLENNIUM MANAGEMENT LLC |
228,678 |
1,804,000 |
1.07% |
|
|
| 17 |
STATE STREET CORP |
223,373 |
1,764,000 |
1.05% |
|
|
| 18 |
NORTHERN TRUST CORP |
203,589 |
1,606,000 |
0.95% |
|
|
| 19 |
BlackRock Institutional Trust Company, N.A. |
153,263 |
1,209,000 |
0.72% |
|
|
| 20 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
151,225 |
1,193,000 |
0.71% |
|
|
| 21 |
JANE STREET GROUP, LLC |
149,707 |
1,181,000 |
0.70% |
|
|
| 22 |
HIGHLAND CAPITAL MANAGEMENT LP |
145,745 |
1,150,000 |
0.68% |
|
|
| 23 |
GOLDMAN SACHS GROUP INC |
138,002 |
1,089,000 |
0.65% |
|
|
| 24 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
103,100 |
813,000 |
0.48% |
Call |
|
| 25 |
GOLDMAN SACHS GROUP INC |
86,200 |
680,000 |
0.40% |
Put |
|
| 26 |
Bank of New York Mellon Corp |
82,589 |
652,000 |
0.39% |
|
|
| 27 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
82,062 |
647,000 |
0.38% |
|
|
| 28 |
GEODE CAPITAL MANAGEMENT, LLC |
72,007 |
568,000 |
0.34% |
|
|
| 29 |
BlackRock Investment Management, LLC |
46,809 |
369,000 |
0.22% |
|
|
| 30 |
FineMark National Bank & Trust |
45,855 |
362,000 |
0.21% |
|
|
| 31 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
45,500 |
359,000 |
0.21% |
|
|
| 32 |
CREDIT SUISSE AG/ |
41,856 |
330,000 |
0.20% |
|
|
| 33 |
Livingston Group Asset Management CO (operating as Southport Capital Management) |
38,450 |
303,000 |
0.18% |
|
|
| 34 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
37,037 |
292,000 |
0.17% |
|
|
| 35 |
AQR CAPITAL MANAGEMENT LLC |
35,200 |
278,000 |
0.16% |
|
|
| 36 |
ZACKS INVESTMENT MANAGEMENT |
34,232 |
270,000 |
0.16% |
|
|
| 37 |
TEACHERS ADVISORS, LLC |
28,101 |
222,000 |
0.13% |
|
|
| 38 |
CITIGROUP INC |
27,488 |
217,000 |
0.13% |
|
|
| 39 |
ProShare Advisors LLC |
17,149 |
135,000 |
0.08% |
|
|
| 40 |
RHUMBLINE ADVISERS |
15,379 |
121,000 |
0.07% |
|
|
| 41 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
14,665 |
116,000 |
0.07% |
|
|
| 42 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
14,198 |
112,000 |
0.07% |
|
|
| 43 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
13,000 |
103,000 |
0.06% |
Put |
|
| 44 |
Southeast Asset Advisors, LLC |
12,500 |
99,000 |
0.06% |
|
|
| 45 |
CITADEL ADVISORS LLC |
11,945 |
94,000 |
0.06% |
|
|
| 46 |
AMERICAN INTERNATIONAL GROUP, INC. |
11,526 |
90,940 |
0.05% |
|
|
| 47 |
GUGGENHEIM CAPITAL LLC |
11,200 |
88,000 |
0.05% |
|
|
| 48 |
BLACKROCK ADVISORS LLC |
9,078 |
72,000 |
0.04% |
|
|
| 49 |
DEUTSCHE BANK AG\ |
7,918 |
62,000 |
0.04% |
|
|
| 50 |
FIRST MANHATTAN CO. LLC. |
7,000 |
55,000 |
0.03% |
|
|
