| 1 |
Scale Management, LLC |
4,558,491 |
25,254,000 |
14.88% |
|
|
| 2 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
4,045,826 |
22,414,000 |
13.21% |
|
|
| 3 |
Polaris Venture Management Co IV LLC |
3,148,355 |
17,442,000 |
10.28% |
|
|
| 4 |
Palo Alto Investors LP |
3,013,793 |
16,696,000 |
9.84% |
|
|
| 5 |
GREAT POINT PARTNERS LLC |
2,619,853 |
14,514,000 |
8.55% |
|
|
| 6 |
NORTH RUN CAPITAL, LP |
2,125,730 |
11,777,000 |
6.94% |
|
|
| 7 |
ORBIMED ADVISORS LLC |
1,500,000 |
8,310,000 |
4.90% |
|
|
| 8 |
BlackRock Fund Advisors |
1,249,598 |
6,923,000 |
4.08% |
|
|
| 9 |
ACUTA CAPITAL PARTNERS, LLC |
1,056,809 |
5,855,000 |
3.45% |
|
|
| 10 |
PURA VIDA INVESTMENTS, LLC |
952,904 |
5,279,000 |
3.11% |
|
|
| 11 |
VANGUARD GROUP INC |
819,486 |
4,540,000 |
2.68% |
|
|
| 12 |
Avoro Capital Advisors LLC |
674,593 |
3,389,000 |
2.00% |
|
|
| 13 |
DEUTSCHE BANK AG\ |
569,732 |
3,155,000 |
1.86% |
|
|
| 14 |
PERCEPTIVE ADVISORS LLC |
381,900 |
2,115,000 |
1.25% |
|
|
| 15 |
SUFFOLK CAPITAL MANAGEMENT LLC |
366,354 |
2,030,000 |
1.20% |
|
|
| 16 |
MILLENNIUM MANAGEMENT LLC |
353,597 |
1,959,000 |
1.15% |
|
|
| 17 |
NORTHERN TRUST CORP |
273,212 |
1,514,000 |
0.89% |
|
|
| 18 |
STATE STREET CORP |
263,770 |
1,460,000 |
0.86% |
|
|
| 19 |
BlackRock Institutional Trust Company, N.A. |
211,345 |
1,171,000 |
0.69% |
|
|
| 20 |
New Leaf Venture Partners, L.L.C. |
209,691 |
1,162,000 |
0.68% |
|
|
| 21 |
PURA VIDA INVESTMENTS, LLC |
205,000 |
1,136,000 |
0.67% |
Call |
|
| 22 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
151,225 |
838,000 |
0.49% |
|
|
| 23 |
GOLDMAN SACHS GROUP INC |
138,700 |
768,000 |
0.45% |
Put |
|
| 24 |
GEODE CAPITAL MANAGEMENT, LLC |
123,295 |
683,000 |
0.40% |
|
|
| 25 |
Bank of New York Mellon Corp |
112,742 |
625,000 |
0.37% |
|
|
| 26 |
Healthcare Value Capital, LLC |
100,000 |
554,000 |
0.33% |
|
|
| 27 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
95,737 |
530,000 |
0.31% |
|
|
| 28 |
JPMORGAN CHASE & CO |
88,783 |
492,000 |
0.29% |
|
|
| 29 |
Cheyne Capital Management (UK) LLP |
76,083 |
422,000 |
0.25% |
|
|
| 30 |
BlackRock Investment Management, LLC |
74,599 |
413,000 |
0.24% |
|
|
| 31 |
CREDIT SUISSE AG/ |
71,927 |
398,000 |
0.23% |
|
|
| 32 |
TWO SIGMA INVESTMENTS, LP |
68,679 |
380,000 |
0.22% |
|
|
| 33 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
65,078 |
361,000 |
0.21% |
|
|
| 34 |
OXFORD ASSET MANAGEMENT LLP |
62,581 |
347,000 |
0.20% |
|
|
| 35 |
MENTA CAPITAL LLC |
62,537 |
346,000 |
0.20% |
|
|
| 36 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
56,600 |
314,000 |
0.19% |
Put |
|
| 37 |
AQR CAPITAL MANAGEMENT LLC |
52,900 |
293,000 |
0.17% |
|
|
| 38 |
Healthcare Value Capital, LLC |
50,000 |
277,000 |
0.16% |
Call |
|
| 39 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
48,419 |
268,000 |
0.16% |
|
|
| 40 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
45,500 |
253,000 |
0.15% |
|
|
| 41 |
STRS OHIO |
43,569 |
241,000 |
0.14% |
|
|
| 42 |
ROYAL BANK OF CANADA |
40,000 |
222,000 |
0.13% |
Call |
|
| 43 |
Livingston Group Asset Management CO (operating as Southport Capital Management) |
36,650 |
203,000 |
0.12% |
|
|
| 44 |
TEACHERS ADVISORS, LLC |
36,569 |
203,000 |
0.12% |
|
|
| 45 |
ProShare Advisors LLC |
34,968 |
194,000 |
0.11% |
|
|
| 46 |
FineMark National Bank & Trust |
31,201 |
173,000 |
0.10% |
|
|
| 47 |
ROYAL BANK OF CANADA |
25,000 |
139,000 |
0.08% |
|
|
| 48 |
MORGAN STANLEY |
23,507 |
130,000 |
0.08% |
|
|
| 49 |
GOLDMAN SACHS GROUP INC |
23,489 |
130,000 |
0.08% |
|
|
| 50 |
ONTARIO TEACHERS PENSION PLAN BOARD |
21,785 |
121,000 |
0.07% |
|
|
