| 1 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
5,878,015 |
14,225,000 |
19.15% |
|
|
| 2 |
Scale Management, LLC |
4,477,391 |
10,835,000 |
14.58% |
|
|
| 3 |
NORTH RUN CAPITAL, LP |
3,500,000 |
8,470,000 |
11.40% |
|
|
| 4 |
Polaris Venture Management Co IV LLC |
3,148,355 |
7,619,000 |
10.26% |
|
|
| 5 |
Palo Alto Investors LP |
3,013,793 |
7,293,000 |
9.82% |
|
|
| 6 |
GOLDMAN SACHS GROUP INC |
1,615,581 |
3,910,000 |
5.26% |
|
|
| 7 |
ORBIMED ADVISORS LLC |
1,500,000 |
3,630,000 |
4.89% |
|
|
| 8 |
VANGUARD GROUP INC |
1,040,287 |
2,517,000 |
3.39% |
|
|
| 9 |
ACUTA CAPITAL PARTNERS, LLC |
974,318 |
2,358,000 |
3.17% |
|
|
| 10 |
BlackRock Fund Advisors |
813,711 |
1,969,000 |
2.65% |
|
|
| 11 |
Jefferies Group LLC |
516,100 |
1,249,000 |
1.68% |
Put |
|
| 12 |
Jefferies Group LLC |
487,186 |
1,179,000 |
1.59% |
|
|
| 13 |
NORTHERN TRUST CORP |
315,568 |
764,000 |
1.03% |
|
|
| 14 |
STATE STREET CORP |
312,956 |
757,000 |
1.02% |
|
|
| 15 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
274,069 |
663,000 |
0.89% |
|
|
| 16 |
BlackRock Institutional Trust Company, N.A. |
228,369 |
553,000 |
0.74% |
|
|
| 17 |
Spark Investment Management LLC |
224,200 |
542,000 |
0.73% |
|
|
| 18 |
ORBIMED ADVISORS LLC |
200,000 |
484,000 |
0.65% |
Call |
|
| 19 |
DEUTSCHE BANK AG\ |
188,950 |
457,000 |
0.62% |
|
|
| 20 |
MILLENNIUM MANAGEMENT LLC |
176,762 |
428,000 |
0.58% |
|
|
| 21 |
GEODE CAPITAL MANAGEMENT, LLC |
175,232 |
424,000 |
0.57% |
|
|
| 22 |
OXFORD ASSET MANAGEMENT LLP |
157,461 |
387,000 |
0.52% |
|
|
| 23 |
PURA VIDA INVESTMENTS, LLC |
129,597 |
314,000 |
0.42% |
|
|
| 24 |
BlackRock Investment Management, LLC |
109,374 |
265,000 |
0.36% |
|
|
| 25 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
103,679 |
251,000 |
0.34% |
|
|
| 26 |
Weiss Multi-Strategy Advisers LLC |
101,000 |
244,000 |
0.33% |
|
|
| 27 |
Bank of New York Mellon Corp |
93,964 |
227,000 |
0.31% |
|
|
| 28 |
RENAISSANCE TECHNOLOGIES LLC |
75,200 |
182,000 |
0.24% |
|
|
| 29 |
Cheyne Capital Management (UK) LLP |
73,000 |
177,000 |
0.24% |
|
|
| 30 |
Virtu KCG Holdings LLC |
72,600 |
176,000 |
0.24% |
|
|
| 31 |
J. Goldman & Co LP |
70,300 |
170,000 |
0.23% |
|
|
| 32 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
56,343 |
136,000 |
0.18% |
|
|
| 33 |
TEACHERS ADVISORS, LLC |
54,275 |
131,000 |
0.18% |
|
|
| 34 |
ARDSLEY ADVISORY PARTNERS LP |
50,000 |
121,000 |
0.16% |
|
|
| 35 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
46,400 |
112,000 |
0.15% |
Call |
|
| 36 |
STRS OHIO |
43,569 |
105,000 |
0.14% |
|
|
| 37 |
Livingston Group Asset Management CO (operating as Southport Capital Management) |
41,250 |
100,000 |
0.13% |
|
|
| 38 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
31,400 |
76,000 |
0.10% |
|
|
| 39 |
RHUMBLINE ADVISERS |
30,835 |
75,000 |
0.10% |
|
|
| 40 |
GUGGENHEIM CAPITAL LLC |
30,090 |
74,000 |
0.10% |
|
|
| 41 |
NEW YORK STATE COMMON RETIREMENT FUND |
27,700 |
67,000 |
0.09% |
|
|
| 42 |
DekaBank Deutsche Girozentrale |
22,500 |
55,000 |
0.07% |
|
|
| 43 |
A.R.T. Advisors, LLC |
22,231 |
53,000 |
0.07% |
|
|
| 44 |
Nationwide Fund Advisors |
20,189 |
49,000 |
0.07% |
|
|
| 45 |
PARAMETRIC PORTFOLIO ASSOCIATES LLC |
20,426 |
49,000 |
0.07% |
|
|
| 46 |
AMERICAN INTERNATIONAL GROUP, INC. |
17,812 |
43,000 |
0.06% |
|
|
| 47 |
BLACKROCK ADVISORS LLC |
15,603 |
38,000 |
0.05% |
|
|
| 48 |
CUTLER GROUP LLC / CA |
16,090 |
38,000 |
0.05% |
|
|
| 49 |
CREDIT SUISSE AG/ |
14,018 |
34,000 |
0.05% |
|
|
| 50 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
13,826 |
33,000 |
0.04% |
|
|
