| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Polaris Venture Management Co IV LLC | 3,148,355 | 17,064,000 | 14.87% | ||
| 2 | Palo Alto Investors LP | 3,040,260 | 16,478,000 | 14.36% | ||
| 3 | GREAT POINT PARTNERS LLC | 2,619,853 | 14,200,000 | 12.37% | ||
| 4 | NORTH RUN CAPITAL, LP | 2,125,730 | 11,521,000 | 10.04% | ||
| 5 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,851,890 | 10,037,000 | 8.75% | ||
| 6 | ORBIMED ADVISORS LLC | 1,500,000 | 8,130,000 | 7.08% | ||
| 7 | VANGUARD GROUP INC | 696,345 | 3,774,000 | 3.29% | ||
| 8 | GOLDMAN SACHS GROUP INC | 649,600 | 3,521,000 | 3.07% | Call | |
| 9 | BlackRock Fund Advisors | 616,419 | 3,341,000 | 2.91% | ||
| 10 | DEUTSCHE BANK AG\ | 498,755 | 2,703,000 | 2.36% | ||
| 11 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 406,200 | 2,202,000 | 1.92% | Put | |
| 12 | GOLDMAN SACHS GROUP INC | 369,500 | 2,003,000 | 1.75% | Put | |
| 13 | MORGAN STANLEY | 367,322 | 1,990,000 | 1.73% | ||
| 14 | NORTHERN TRUST CORP | 264,958 | 1,436,000 | 1.25% | ||
| 15 | STATE STREET CORP | 250,705 | 1,362,000 | 1.19% | ||
| 16 | RA CAPITAL MANAGEMENT, L.P. | 243,726 | 1,321,000 | 1.15% | ||
| 17 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 232,600 | 1,261,000 | 1.10% | Call | |
| 18 | BlackRock Institutional Trust Company, N.A. | 216,265 | 1,172,000 | 1.02% | ||
| 19 | Ghost Tree Capital, LLC | 200,000 | 1,084,000 | 0.94% | Put | |
| 20 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 180,605 | 979,000 | 0.85% | ||
| 21 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 151,225 | 820,000 | 0.71% | ||
| 22 | MILLENNIUM MANAGEMENT LLC | 145,357 | 788,000 | 0.69% | ||
| 23 | GOLDMAN SACHS GROUP INC | 143,978 | 780,000 | 0.68% | ||
| 24 | Bank of New York Mellon Corp | 116,140 | 629,000 | 0.55% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 101,952 | 552,000 | 0.48% | ||
| 26 | TIAA CREF INVESTMENT MANAGEMENT LLC | 100,789 | 546,000 | 0.48% | ||
| 27 | BlackRock Investment Management, LLC | 75,004 | 407,000 | 0.35% | ||
| 28 | BANK OF MONTREAL /CAN/ | 72,727 | 394,000 | 0.34% | ||
| 29 | ROYAL BANK OF CANADA | 64,800 | 351,000 | 0.31% | Call | |
| 30 | FineMark National Bank & Trust | 55,855 | 303,000 | 0.26% | ||
| 31 | AQR CAPITAL MANAGEMENT LLC | 52,500 | 285,000 | 0.25% | ||
| 32 | Jefferies Group LLC | 51,600 | 280,000 | 0.24% | Call | |
| 33 | SABBY MANAGEMENT, LLC | 50,000 | 271,000 | 0.24% | ||
| 34 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 48,212 | 261,000 | 0.23% | ||
| 35 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 45,500 | 247,000 | 0.22% | ||
| 36 | TEACHERS ADVISORS, LLC | 36,569 | 198,000 | 0.17% | ||
| 37 | Livingston Group Asset Management CO (operating as Southport Capital Management) | 36,050 | 195,000 | 0.17% | ||
| 38 | TWO SIGMA INVESTMENTS, LP | 27,000 | 146,000 | 0.13% | ||
| 39 | ROYAL BANK OF CANADA | 25,000 | 136,000 | 0.12% | ||
| 40 | CREDIT SUISSE AG/ | 24,160 | 131,000 | 0.11% | ||
| 41 | RHUMBLINE ADVISERS | 20,843 | 113,000 | 0.10% | ||
| 42 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 20,652 | 112,000 | 0.10% | ||
| 43 | BARCLAYS PLC | 21,900 | 110,000 | 0.10% | Put | |
| 44 | HAMILTON LANE ADVISORS LLC | 20,000 | 108,000 | 0.09% | ||
| 45 | Nationwide Fund Advisors | 19,976 | 108,000 | 0.09% | ||
| 46 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 19,651 | 107,000 | 0.09% | ||
| 47 | Spark Investment Management LLC | 17,200 | 93,000 | 0.08% | ||
| 48 | AMERICAN INTERNATIONAL GROUP, INC. | 17,141 | 92,904 | 0.08% | ||
| 49 | NATIXIS | 16,500 | 89,000 | 0.08% | ||
| 50 | UBS AG | 13,800 | 75,000 | 0.07% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
