| 1 |
Scale Management, LLC |
4,478,323 |
20,645,000 |
14.64% |
|
|
| 2 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
4,420,580 |
20,379,000 |
14.45% |
|
|
| 3 |
NORTH RUN CAPITAL, LP |
3,448,255 |
15,896,000 |
11.28% |
|
|
| 4 |
Polaris Venture Management Co IV LLC |
3,148,355 |
14,514,000 |
10.29% |
|
|
| 5 |
Palo Alto Investors LP |
3,013,793 |
13,894,000 |
9.86% |
|
|
| 6 |
GREAT POINT PARTNERS LLC |
1,683,162 |
7,759,000 |
5.50% |
|
|
| 7 |
ORBIMED ADVISORS LLC |
1,500,000 |
6,915,000 |
4.90% |
|
|
| 8 |
BlackRock Fund Advisors |
1,331,917 |
6,140,000 |
4.36% |
|
|
| 9 |
PURA VIDA INVESTMENTS, LLC |
1,243,807 |
5,995,000 |
4.25% |
|
|
| 10 |
ACUTA CAPITAL PARTNERS, LLC |
974,318 |
4,492,000 |
3.19% |
|
|
| 11 |
VANGUARD GROUP INC |
878,453 |
4,050,000 |
2.87% |
|
|
| 12 |
SUFFOLK CAPITAL MANAGEMENT LLC |
642,168 |
2,960,000 |
2.10% |
|
|
| 13 |
DEUTSCHE BANK AG\ |
630,062 |
2,903,000 |
2.06% |
|
|
| 14 |
GOLDMAN SACHS GROUP INC |
356,195 |
1,642,000 |
1.16% |
|
|
| 15 |
MILLENNIUM MANAGEMENT LLC |
294,097 |
1,356,000 |
0.96% |
|
|
| 16 |
NORTHERN TRUST CORP |
268,915 |
1,240,000 |
0.88% |
|
|
| 17 |
PUTNAM INVESTMENTS LLC |
237,988 |
1,097,000 |
0.78% |
|
|
| 18 |
GOLDMAN SACHS GROUP INC |
200,000 |
922,000 |
0.65% |
Call |
|
| 19 |
BlackRock Institutional Trust Company, N.A. |
196,648 |
907,000 |
0.64% |
|
|
| 20 |
GEODE CAPITAL MANAGEMENT, LLC |
153,897 |
709,000 |
0.50% |
|
|
| 21 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
151,225 |
697,000 |
0.49% |
|
|
| 22 |
Bank of New York Mellon Corp |
115,444 |
533,000 |
0.38% |
|
|
| 23 |
BlackRock Investment Management, LLC |
111,881 |
516,000 |
0.37% |
|
|
| 24 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
103,679 |
478,000 |
0.34% |
|
|
| 25 |
Healthcare Value Capital, LLC |
100,000 |
461,000 |
0.33% |
|
|
| 26 |
Cheyne Capital Management (UK) LLP |
73,000 |
336,000 |
0.24% |
|
|
| 27 |
Weiss Multi-Strategy Advisers LLC |
70,000 |
323,000 |
0.23% |
|
|
| 28 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
55,544 |
256,000 |
0.18% |
|
|
| 29 |
CREDIT SUISSE AG/ |
51,091 |
236,000 |
0.17% |
|
|
| 30 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
45,500 |
210,000 |
0.15% |
|
|
| 31 |
OXFORD ASSET MANAGEMENT LLP |
45,004 |
207,000 |
0.15% |
|
|
| 32 |
TEACHERS ADVISORS, LLC |
44,696 |
206,000 |
0.15% |
|
|
| 33 |
STRS OHIO |
43,569 |
200,000 |
0.14% |
|
|
| 34 |
Livingston Group Asset Management CO (operating as Southport Capital Management) |
41,250 |
190,000 |
0.13% |
|
|
| 35 |
ProShare Advisors LLC |
39,312 |
181,000 |
0.13% |
|
|
| 36 |
FineMark National Bank & Trust |
32,201 |
148,000 |
0.10% |
|
|
| 37 |
NEW YORK STATE COMMON RETIREMENT FUND |
31,148 |
144,000 |
0.10% |
|
|
| 38 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
28,500 |
131,000 |
0.09% |
|
|
| 39 |
RHUMBLINE ADVISERS |
27,033 |
125,000 |
0.09% |
|
|
| 40 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
21,600 |
100,000 |
0.07% |
Call |
|
| 41 |
DekaBank Deutsche Girozentrale |
21,500 |
99,000 |
0.07% |
|
|
| 42 |
Nationwide Fund Advisors |
20,189 |
93,000 |
0.07% |
|
|
| 43 |
BLACKROCK ADVISORS LLC |
19,678 |
91,000 |
0.06% |
|
|
| 44 |
MORGAN STANLEY |
19,225 |
89,000 |
0.06% |
|
|
| 45 |
AQR CAPITAL MANAGEMENT LLC |
18,602 |
86,000 |
0.06% |
|
|
| 46 |
AMERICAN INTERNATIONAL GROUP, INC. |
17,822 |
82,159 |
0.06% |
|
|
| 47 |
SG Americas Securities, LLC |
17,268 |
80,000 |
0.06% |
|
|
| 48 |
BALYASNY ASSET MANAGEMENT L.P. |
10,375 |
48,000 |
0.03% |
|
|
| 49 |
Southeast Asset Advisors, LLC |
10,000 |
46,000 |
0.03% |
|
|
| 50 |
ARDSLEY ADVISORY PARTNERS LP |
10,000 |
46,000 |
0.03% |
|
|
