| 1 |
Palo Alto Investors LP |
3,634,984 |
21,737,000 |
17.88% |
|
|
| 2 |
Polaris Venture Management Co IV LLC |
3,148,355 |
18,827,000 |
15.48% |
|
|
| 3 |
NORTH RUN CAPITAL, LP |
1,950,000 |
11,661,000 |
9.59% |
|
|
| 4 |
GREAT POINT PARTNERS LLC |
1,610,316 |
9,630,000 |
7.92% |
|
|
| 5 |
ORBIMED ADVISORS LLC |
1,500,000 |
8,970,000 |
7.38% |
|
|
| 6 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
1,311,290 |
7,842,000 |
6.45% |
|
|
| 7 |
COLUMBIA WANGER ASSET MANAGEMENT LLC |
1,168,298 |
6,986,000 |
5.74% |
|
|
| 8 |
GOLDMAN SACHS GROUP INC |
763,600 |
4,566,000 |
3.75% |
Call |
|
| 9 |
RA CAPITAL MANAGEMENT, L.P. |
666,667 |
3,987,000 |
3.28% |
|
|
| 10 |
BlackRock Fund Advisors |
640,698 |
3,831,000 |
3.15% |
|
|
| 11 |
VANGUARD GROUP INC |
579,926 |
3,468,000 |
2.85% |
|
|
| 12 |
MORGAN STANLEY |
374,626 |
2,240,000 |
1.84% |
|
|
| 13 |
STATE STREET CORP |
242,478 |
1,451,000 |
1.19% |
|
|
| 14 |
BlackRock Institutional Trust Company, N.A. |
233,081 |
1,394,000 |
1.15% |
|
|
| 15 |
NORTHERN TRUST CORP |
216,890 |
1,297,000 |
1.07% |
|
|
| 16 |
Informed Momentum Co LLC |
205,385 |
1,228,000 |
1.01% |
|
|
| 17 |
GOLDMAN SACHS GROUP INC |
184,000 |
1,100,000 |
0.90% |
Put |
|
| 18 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
177,800 |
1,063,000 |
0.87% |
Call |
|
| 19 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
151,225 |
904,000 |
0.74% |
|
|
| 20 |
MILLENNIUM MANAGEMENT LLC |
146,077 |
874,000 |
0.72% |
|
|
| 21 |
Bank of New York Mellon Corp |
112,134 |
670,000 |
0.55% |
|
|
| 22 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
110,376 |
660,000 |
0.54% |
|
|
| 23 |
SABBY MANAGEMENT, LLC |
100,000 |
598,000 |
0.49% |
|
|
| 24 |
GOLDMAN SACHS GROUP INC |
88,750 |
531,000 |
0.44% |
|
|
| 25 |
HIGHLAND CAPITAL MANAGEMENT LP |
88,500 |
529,000 |
0.44% |
|
|
| 26 |
Alyeska Investment Group, L.P. |
85,000 |
508,000 |
0.42% |
|
|
| 27 |
GEODE CAPITAL MANAGEMENT, LLC |
76,616 |
458,000 |
0.38% |
|
|
| 28 |
BlackRock Investment Management, LLC |
75,346 |
451,000 |
0.37% |
|
|
| 29 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
63,800 |
382,000 |
0.31% |
Put |
|
| 30 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
55,869 |
334,000 |
0.27% |
|
|
| 31 |
AQR CAPITAL MANAGEMENT LLC |
52,500 |
314,000 |
0.26% |
|
|
| 32 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
47,837 |
286,000 |
0.24% |
|
|
| 33 |
CREDIT SUISSE AG/ |
46,987 |
281,000 |
0.23% |
|
|
| 34 |
FineMark National Bank & Trust |
45,855 |
274,000 |
0.23% |
|
|
| 35 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
45,500 |
273,000 |
0.22% |
|
|
| 36 |
TEACHERS ADVISORS, LLC |
36,569 |
219,000 |
0.18% |
|
|
| 37 |
Livingston Group Asset Management CO (operating as Southport Capital Management) |
35,450 |
212,000 |
0.17% |
|
|
| 38 |
TWO SIGMA INVESTMENTS, LP |
33,891 |
203,000 |
0.17% |
|
|
| 39 |
DEUTSCHE BANK AG\ |
29,225 |
174,000 |
0.14% |
|
|
| 40 |
RHUMBLINE ADVISERS |
20,843 |
125,000 |
0.10% |
|
|
| 41 |
Nationwide Fund Advisors |
19,976 |
119,000 |
0.10% |
|
|
| 42 |
JANE STREET GROUP, LLC |
18,369 |
110,000 |
0.09% |
|
|
| 43 |
AMERICAN INTERNATIONAL GROUP, INC. |
17,154 |
102,581 |
0.08% |
|
|
| 44 |
BANK OF AMERICA CORP /DE/ |
15,086 |
90,000 |
0.07% |
|
|
| 45 |
Rotella Capital Management, Inc. |
13,833 |
83,000 |
0.07% |
|
|
| 46 |
ProShare Advisors LLC |
12,778 |
76,000 |
0.06% |
|
|
| 47 |
Southeast Asset Advisors, LLC |
12,500 |
75,000 |
0.06% |
|
|
| 48 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
11,718 |
70,000 |
0.06% |
|
|
| 49 |
BLACKROCK ADVISORS LLC |
10,857 |
65,000 |
0.05% |
|
|
| 50 |
FIRST MANHATTAN CO. LLC. |
10,000 |
59,000 |
0.05% |
|
|
