| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 4,204,702 | 135,602,000 | 10.45% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 3,576,690 | 115,348,000 | 8.89% | ||
| 3 | Palo Alto Investors LP | 2,521,822 | 81,329,000 | 6.27% | ||
| 4 | EAGLE ASSET MANAGEMENT INC | 2,328,177 | 75,083,000 | 5.79% | ||
| 5 | BlackRock Fund Advisors | 1,752,982 | 56,534,000 | 4.36% | ||
| 6 | VANGUARD GROUP INC | 1,727,640 | 55,716,000 | 4.29% | ||
| 7 | Point72 Asset Management, L.P. | 1,564,343 | 50,450,000 | 3.89% | ||
| 8 | Consonance Capital Management LP | 1,469,690 | 47,398,000 | 3.65% | ||
| 9 | FARALLON CAPITAL MANAGEMENT LLC | 1,385,000 | 44,666,000 | 3.44% | ||
| 10 | FMR LLC | 1,360,915 | 43,890,000 | 3.38% | ||
| 11 | VHCP Management, LLC | 1,178,474 | 38,006,000 | 2.93% | ||
| 12 | RHO CAPITAL PARTNERS INC | 1,067,892 | 34,440,000 | 2.65% | ||
| 13 | Bank of New York Mellon Corp | 1,049,266 | 33,839,000 | 2.61% | ||
| 14 | STATE STREET CORP | 1,045,991 | 33,731,000 | 2.60% | ||
| 15 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 1,019,275 | 32,872,000 | 2.53% | ||
| 16 | MILLENNIUM MANAGEMENT LLC | 953,382 | 30,747,000 | 2.37% | ||
| 17 | Lombard Odier Asset Management (USA) Corp | 750,000 | 24,188,000 | 1.86% | ||
| 18 | OppenheimerFunds, Inc. | 600,000 | 19,350,000 | 1.49% | ||
| 19 | BlackRock Institutional Trust Company, N.A. | 596,816 | 19,247,000 | 1.48% | ||
| 20 | Century Capital Management, LLC | 547,043 | 17,642,000 | 1.36% | ||
| 21 | Broadfin Capital, LLC | 504,320 | 16,264,000 | 1.25% | ||
| 22 | LOOMIS SAYLES & CO L P | 476,798 | 15,377,000 | 1.18% | ||
| 23 | PFM Health Sciences, LP | 446,119 | 14,387,000 | 1.11% | ||
| 24 | NORTHERN TRUST CORP | 416,825 | 13,442,000 | 1.04% | ||
| 25 | QVT Financial LP | 373,953 | 12,060,000 | 0.93% | ||
| 26 | OXFORD ASSET MANAGEMENT LLP | 357,363 | 11,611,000 | 0.89% | ||
| 27 | ROYCE & ASSOCIATES LP | 340,500 | 10,981,000 | 0.85% | ||
| 28 | JENNISON ASSOCIATES LLC | 330,836 | 10,669,000 | 0.82% | ||
| 29 | Alyeska Investment Group, L.P. | 324,465 | 10,464,000 | 0.81% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 264,443 | 8,527,000 | 0.66% | ||
| 31 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 263,558 | 8,499,000 | 0.65% | ||
| 32 | CADIAN CAPITAL MANAGEMENT, LP | 250,000 | 8,063,000 | 0.62% | ||
| 33 | DEUTSCHE BANK AG\ | 242,160 | 7,807,000 | 0.60% | ||
| 34 | BLACKROCK ADVISORS LLC | 209,148 | 6,745,000 | 0.52% | ||
| 35 | MARSHALL WACE, LLP | 197,799 | 6,379,000 | 0.49% | ||
| 36 | INVESTMENT MANAGEMENT OF VIRGINIA LLC | 196,557 | 6,339,000 | 0.49% | ||
| 37 | CREDIT SUISSE AG/ | 179,035 | 5,774,000 | 0.44% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 149,400 | 4,818,000 | 0.37% | Put | |
| 39 | UBS Group AG | 145,829 | 4,703,000 | 0.36% | ||
| 40 | AMERICAN CENTURY COMPANIES INC | 141,348 | 4,558,000 | 0.35% | ||
| 41 | MASON STREET ADVISORS, LLC | 134,646 | 4,342,000 | 0.33% | ||
| 42 | TIAA CREF INVESTMENT MANAGEMENT LLC | 131,219 | 4,232,000 | 0.33% | ||
| 43 | MANAGED ACCOUNT ADVISORS LLC | 127,303 | 4,105,000 | 0.32% | ||
| 44 | Forward Management, LLC | 125,367 | 4,055,000 | 0.31% | ||
| 45 | GUGGENHEIM CAPITAL LLC | 120,945 | 3,900,000 | 0.30% | ||
| 46 | Candriam S.C.A. | 120,000 | 3,870,000 | 0.30% | ||
| 47 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 118,053 | 3,808,000 | 0.29% | ||
| 48 | BlackRock Investment Management, LLC | 114,324 | 3,687,000 | 0.28% | ||
| 49 | LORD, ABBETT & CO. LLC | 109,652 | 3,536,000 | 0.27% | ||
| 50 | EverPoint Asset Management, LLC | 100,000 | 3,225,000 | 0.25% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
