| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,727,521 | 359,586,000 | 13.61% | ||
| 2 | BAKER BROS. ADVISORS LP | 5,122,375 | 273,791,000 | 10.36% | ||
| 3 | VANGUARD GROUP INC | 2,889,546 | 154,447,000 | 5.85% | ||
| 4 | Palo Alto Investors LP | 2,219,042 | 118,608,000 | 4.49% | ||
| 5 | BlackRock Fund Advisors | 1,783,935 | 95,351,000 | 3.61% | ||
| 6 | WELLINGTON MANAGEMENT GROUP LLP | 1,771,058 | 94,662,000 | 3.58% | ||
| 7 | GOLDMAN SACHS GROUP INC | 1,561,729 | 83,475,000 | 3.16% | ||
| 8 | FRANKLIN RESOURCES INC | 1,327,948 | 70,980,000 | 2.69% | ||
| 9 | STATE STREET CORP | 1,315,892 | 70,334,000 | 2.66% | ||
| 10 | JANUS HENDERSON INVESTORS US LLC | 1,270,630 | 67,917,000 | 2.57% | ||
| 11 | BLACKROCK ADVISORS LLC | 1,121,252 | 59,931,000 | 2.27% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 1,072,344 | 57,317,000 | 2.17% | ||
| 13 | RHO CAPITAL PARTNERS INC | 1,067,892 | 57,079,000 | 2.16% | ||
| 14 | Point72 Asset Management, L.P. | 928,440 | 49,625,000 | 1.88% | ||
| 15 | EAGLE ASSET MANAGEMENT INC | 922,101 | 49,286,000 | 1.87% | ||
| 16 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 801,510 | 42,841,000 | 1.62% | ||
| 17 | GOLDMAN SACHS GROUP INC | 785,000 | 41,958,000 | 1.59% | Call | |
| 18 | ALLIANCEBERNSTEIN L.P. | 661,534 | 35,359,000 | 1.34% | ||
| 19 | Invesco Ltd. | 650,231 | 34,755,000 | 1.32% | ||
| 20 | USS Investment Management Ltd | 643,838 | 34,432,000 | 1.30% | ||
| 21 | OppenheimerFunds, Inc. | 584,989 | 31,267,000 | 1.18% | ||
| 22 | BlackRock Group LTD | 574,642 | 30,716,000 | 1.16% | ||
| 23 | GOLDMAN SACHS GROUP INC | 543,200 | 29,034,000 | 1.10% | Put | |
| 24 | JENNISON ASSOCIATES LLC | 507,404 | 27,121,000 | 1.03% | ||
| 25 | NEXT CENTURY GROWTH INVESTORS LLC | 500,123 | 26,731,000 | 1.01% | ||
| 26 | NORTHERN TRUST CORP | 494,781 | 26,447,000 | 1.00% | ||
| 27 | York Capital Management Global Advisors, LLC | 464,618 | 24,834,000 | 0.94% | ||
| 28 | Bank of New York Mellon Corp | 460,299 | 24,603,000 | 0.93% | ||
| 29 | Broadfin Capital, LLC | 400,000 | 21,380,000 | 0.81% | Call | |
| 30 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 350,000 | 18,708,000 | 0.71% | ||
| 31 | NORGES BANK | 332,886 | 17,793,000 | 0.67% | ||
| 32 | PointState Capital LP | 325,000 | 17,371,000 | 0.66% | ||
| 33 | MORGAN STANLEY | 321,510 | 17,185,000 | 0.65% | ||
| 34 | CITADEL ADVISORS LLC | 313,988 | 16,783,000 | 0.64% | ||
| 35 | GEODE CAPITAL MANAGEMENT, LLC | 312,998 | 16,729,000 | 0.63% | ||
| 36 | JPMORGAN CHASE & CO | 307,192 | 16,419,000 | 0.62% | ||
| 37 | PRICE T ROWE ASSOCIATES INC /MD/ | 300,562 | 16,065,000 | 0.61% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 239,600 | 12,807,000 | 0.48% | Call | |
| 39 | Apex Capital Management | 235,567 | 12,591,000 | 0.48% | ||
| 40 | VOYA INVESTMENT MANAGEMENT LLC | 235,387 | 12,582,000 | 0.48% | ||
| 41 | RUSSELL FRANK CO/ | 226,757 | 12,120,000 | 0.46% | ||
| 42 | BlackRock Investment Management, LLC | 216,460 | 11,570,000 | 0.44% | ||
| 43 | DEUTSCHE BANK AG\ | 203,576 | 10,879,000 | 0.41% | ||
| 44 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 191,500 | 10,236,000 | 0.39% | Put | |
| 45 | SUFFOLK CAPITAL MANAGEMENT LLC | 185,321 | 9,905,000 | 0.37% | ||
| 46 | TIAA CREF INVESTMENT MANAGEMENT LLC | 178,668 | 9,550,000 | 0.36% | ||
| 47 | Rock Springs Capital Management LP | 177,500 | 9,487,000 | 0.36% | ||
| 48 | BANK OF AMERICA CORP /DE/ | 172,011 | 9,194,000 | 0.35% | ||
| 49 | TEACHERS ADVISORS, LLC | 167,953 | 8,977,000 | 0.34% | ||
| 50 | Avoro Capital Advisors LLC | 166,700 | 8,910,000 | 0.34% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
