| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WELLINGTON MANAGEMENT GROUP LLP | 3,500,649 | 70,049,000 | 10.73% | ||
| 2 | BAKER BROS. ADVISORS LP | 3,095,318 | 61,937,000 | 9.49% | ||
| 3 | Consonance Capital Management LP | 1,610,467 | 32,225,000 | 4.94% | ||
| 4 | Palo Alto Investors LP | 1,572,078 | 31,457,000 | 4.82% | ||
| 5 | VHCP Management, LLC | 1,545,999 | 30,935,000 | 4.74% | ||
| 6 | Lombard Odier Asset Management (USA) Corp | 1,375,000 | 27,514,000 | 4.21% | ||
| 7 | EAGLE ASSET MANAGEMENT INC | 1,228,952 | 24,591,000 | 3.77% | ||
| 8 | STATE STREET CORP | 1,221,189 | 24,435,000 | 3.74% | ||
| 9 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 1,219,519 | 24,378,000 | 3.73% | ||
| 10 | BlackRock Fund Advisors | 1,204,181 | 24,096,000 | 3.69% | ||
| 11 | QVT Financial LP | 1,175,903 | 23,530,000 | 3.60% | ||
| 12 | WESTFIELD CAPITAL MANAGEMENT CO LP | 1,138,530 | 22,782,000 | 3.49% | ||
| 13 | RHO CAPITAL PARTNERS INC | 1,067,892 | 21,369,000 | 3.27% | ||
| 14 | PFM Health Sciences, LP | 1,026,745 | 20,545,000 | 3.15% | ||
| 15 | Broadfin Capital, LLC | 1,000,869 | 20,027,000 | 3.07% | ||
| 16 | VANGUARD GROUP INC | 897,716 | 17,963,000 | 2.75% | ||
| 17 | PERCEPTIVE ADVISORS LLC | 647,015 | 12,947,000 | 1.98% | ||
| 18 | INVESTMENT MANAGEMENT OF VIRGINIA LLC | 526,459 | 10,534,000 | 1.61% | ||
| 19 | Bank of New York Mellon Corp | 521,010 | 10,426,000 | 1.60% | ||
| 20 | FMR LLC | 515,716 | 10,319,000 | 1.58% | ||
| 21 | FARALLON CAPITAL MANAGEMENT LLC | 500,000 | 10,005,000 | 1.53% | ||
| 22 | MILLENNIUM MANAGEMENT LLC | 427,497 | 8,554,000 | 1.31% | ||
| 23 | JENNISON ASSOCIATES LLC | 387,568 | 7,755,000 | 1.19% | ||
| 24 | NORTHERN TRUST CORP | 346,582 | 6,936,000 | 1.06% | ||
| 25 | BlackRock Institutional Trust Company, N.A. | 299,089 | 5,985,000 | 0.92% | ||
| 26 | PointState Capital LP | 288,959 | 5,782,000 | 0.89% | ||
| 27 | Invesco Ltd. | 274,270 | 5,488,000 | 0.84% | ||
| 28 | GLG Partners LP | 270,000 | 5,403,000 | 0.83% | ||
| 29 | AXA S.A. | 248,338 | 4,969,000 | 0.76% | ||
| 30 | DEUTSCHE BANK AG\ | 188,372 | 3,767,000 | 0.58% | ||
| 31 | INSIGHT CAPITAL RESEARCH & MANAGEMENT INC | 188,041 | 3,763,000 | 0.58% | ||
| 32 | UBS AG | 168,700 | 3,376,000 | 0.52% | ||
| 33 | GEODE CAPITAL MANAGEMENT, LLC | 162,323 | 3,247,000 | 0.50% | ||
| 34 | Informed Momentum Co LLC | 147,445 | 2,950,000 | 0.45% | ||
| 35 | MANAGED ACCOUNT ADVISORS LLC | 142,724 | 2,856,000 | 0.44% | ||
| 36 | MASON STREET ADVISORS, LLC | 134,646 | 2,694,000 | 0.41% | ||
| 37 | TFS CAPITAL LLC | 132,205 | 2,645,000 | 0.41% | ||
| 38 | TIAA CREF INVESTMENT MANAGEMENT LLC | 96,851 | 1,938,000 | 0.30% | ||
| 39 | CREDIT SUISSE AG/ | 96,028 | 1,921,000 | 0.29% | ||
| 40 | Atika Capital Management LLC | 92,900 | 1,859,000 | 0.28% | ||
| 41 | PUTNAM INVESTMENTS LLC | 80,900 | 1,619,000 | 0.25% | ||
| 42 | DIMENSIONAL FUND ADVISORS LP | 78,454 | 1,570,000 | 0.24% | ||
| 43 | RUSSELL FRANK CO/ | 95,027 | 1,549,000 | 0.24% | ||
| 44 | Weiss Multi-Strategy Advisers LLC | 70,930 | 1,419,000 | 0.22% | ||
| 45 | BlackRock Investment Management, LLC | 70,245 | 1,406,000 | 0.22% | ||
| 46 | OXFORD ASSET MANAGEMENT LLP | 68,109 | 1,363,000 | 0.21% | ||
| 47 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 66,663 | 1,334,000 | 0.20% | ||
| 48 | AMERIPRISE FINANCIAL INC | 62,630 | 1,253,000 | 0.19% | ||
| 49 | AQR CAPITAL MANAGEMENT LLC | 61,630 | 1,233,000 | 0.19% | ||
| 50 | ProShare Advisors LLC | 56,850 | 1,138,000 | 0.17% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
