| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,617,335 | 747,560,000 | 14.88% | ||
| 2 | BAKER BROS. ADVISORS LP | 4,198,520 | 474,307,000 | 9.44% | ||
| 3 | VANGUARD GROUP INC | 2,697,484 | 304,735,000 | 6.06% | ||
| 4 | Palo Alto Investors LP | 2,187,242 | 247,093,000 | 4.92% | ||
| 5 | WELLINGTON MANAGEMENT GROUP LLP | 2,097,242 | 236,927,000 | 4.71% | ||
| 6 | BlackRock Fund Advisors | 1,715,796 | 193,833,000 | 3.86% | ||
| 7 | FRANKLIN RESOURCES INC | 1,394,906 | 157,588,000 | 3.14% | ||
| 8 | JANUS HENDERSON INVESTORS US LLC | 1,071,697 | 121,070,000 | 2.41% | ||
| 9 | RHO CAPITAL PARTNERS INC | 1,067,892 | 120,640,000 | 2.40% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 1,067,202 | 120,562,000 | 2.40% | ||
| 11 | STATE STREET CORP | 995,414 | 112,452,000 | 2.24% | ||
| 12 | EAGLE ASSET MANAGEMENT INC | 970,711 | 109,661,000 | 2.18% | ||
| 13 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 906,287 | 102,383,000 | 2.04% | ||
| 14 | BLACKROCK ADVISORS LLC | 881,172 | 99,546,000 | 1.98% | ||
| 15 | ALLIANCEBERNSTEIN L.P. | 772,132 | 90,888,000 | 1.81% | ||
| 16 | CITADEL ADVISORS LLC | 717,428 | 81,047,000 | 1.61% | ||
| 17 | Bank of New York Mellon Corp | 681,213 | 76,956,000 | 1.53% | ||
| 18 | Invesco Ltd. | 612,230 | 69,163,000 | 1.38% | ||
| 19 | OppenheimerFunds, Inc. | 570,830 | 64,487,000 | 1.28% | ||
| 20 | NEXT CENTURY GROWTH INVESTORS LLC | 496,744 | 56,117,000 | 1.12% | ||
| 21 | NORTHERN TRUST CORP | 494,372 | 55,849,000 | 1.11% | ||
| 22 | BlackRock Group LTD | 472,120 | 53,335,000 | 1.06% | ||
| 23 | WESTFIELD CAPITAL MANAGEMENT CO LP | 406,716 | 45,947,000 | 0.91% | ||
| 24 | GOLDMAN SACHS GROUP INC | 385,146 | 43,510,000 | 0.87% | ||
| 25 | NORGES BANK | 351,941 | 39,759,000 | 0.79% | ||
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 335,500 | 37,901,000 | 0.75% | Call | |
| 27 | JPMORGAN CHASE & CO | 326,562 | 36,890,000 | 0.73% | ||
| 28 | GOLDMAN SACHS GROUP INC | 322,500 | 36,433,000 | 0.73% | Call | |
| 29 | PRICE T ROWE ASSOCIATES INC /MD/ | 305,525 | 34,515,000 | 0.69% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 297,755 | 33,637,000 | 0.67% | ||
| 31 | USS Investment Management Ltd | 267,047 | 30,168,000 | 0.60% | ||
| 32 | VOYA INVESTMENT MANAGEMENT LLC | 252,112 | 28,481,000 | 0.57% | ||
| 33 | JENNISON ASSOCIATES LLC | 238,488 | 26,942,000 | 0.54% | ||
| 34 | GOLDMAN SACHS GROUP INC | 230,000 | 25,983,000 | 0.52% | Put | |
| 35 | DEUTSCHE BANK AG\ | 226,380 | 25,570,000 | 0.51% | ||
| 36 | Century Capital Management, LLC | 220,787 | 24,942,000 | 0.50% | ||
| 37 | Apex Capital Management | 219,488 | 24,796,000 | 0.49% | ||
| 38 | TEACHERS ADVISORS, LLC | 207,919 | 23,489,000 | 0.47% | ||
| 39 | COLUMBUS CIRCLE INVESTORS | 197,790 | 22,344,000 | 0.44% | ||
| 40 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 194,200 | 21,939,000 | 0.44% | Put | |
| 41 | TIAA CREF INVESTMENT MANAGEMENT LLC | 189,175 | 21,371,000 | 0.43% | ||
| 42 | BlackRock Investment Management, LLC | 183,818 | 20,766,000 | 0.41% | ||
| 43 | TWO SIGMA ADVISERS, LP | 163,900 | 18,516,000 | 0.37% | ||
| 44 | D. E. Shaw & Co., Inc. | 158,770 | 17,936,000 | 0.36% | ||
| 45 | TWO SIGMA INVESTMENTS, LP | 155,169 | 17,529,000 | 0.35% | ||
| 46 | UBS Group AG | 155,000 | 17,510,000 | 0.35% | Call | |
| 47 | MILLENNIUM MANAGEMENT LLC | 150,537 | 17,006,000 | 0.34% | ||
| 48 | BANK OF AMERICA CORP /DE/ | 150,178 | 16,965,000 | 0.34% | ||
| 49 | AXA S.A. | 144,884 | 16,367,000 | 0.33% | ||
| 50 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 141,171 | 15,949,000 | 0.32% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
