| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 4,135,412 | 486,779,000 | 10.21% | ||
| 2 | FMR LLC | 3,906,794 | 459,869,000 | 9.65% | ||
| 3 | VANGUARD GROUP INC | 2,619,362 | 308,325,000 | 6.47% | ||
| 4 | Palo Alto Investors LP | 2,579,154 | 303,592,000 | 6.37% | ||
| 5 | WELLINGTON MANAGEMENT GROUP LLP | 2,232,985 | 262,846,000 | 5.52% | ||
| 6 | BlackRock Fund Advisors | 1,797,176 | 211,546,000 | 4.44% | ||
| 7 | MILLENNIUM MANAGEMENT LLC | 1,185,607 | 139,558,000 | 2.93% | ||
| 8 | VHCP Management, LLC | 1,178,474 | 138,718,000 | 2.91% | ||
| 9 | EAGLE ASSET MANAGEMENT INC | 1,172,480 | 138,012,000 | 2.90% | ||
| 10 | RHO CAPITAL PARTNERS INC | 1,067,892 | 125,702,000 | 2.64% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 1,047,012 | 123,244,000 | 2.59% | ||
| 12 | JANUS HENDERSON INVESTORS US LLC | 1,013,374 | 119,284,000 | 2.50% | ||
| 13 | BLACKROCK ADVISORS LLC | 852,360 | 100,331,000 | 2.11% | ||
| 14 | ALLIANCEBERNSTEIN L.P. | 730,296 | 85,963,000 | 1.80% | ||
| 15 | ALPS ADVISORS INC | 57,540 | 67,730,000 | 1.42% | ||
| 16 | CITADEL ADVISORS LLC | 565,531 | 66,569,000 | 1.40% | ||
| 17 | Invesco Ltd. | 533,107 | 62,752,000 | 1.32% | ||
| 18 | OppenheimerFunds, Inc. | 500,000 | 58,855,000 | 1.24% | ||
| 19 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 488,912 | 57,550,000 | 1.21% | ||
| 20 | NORTHERN TRUST CORP | 477,775 | 56,239,000 | 1.18% | ||
| 21 | Bank of New York Mellon Corp | 469,098 | 55,219,000 | 1.16% | ||
| 22 | BlackRock Group LTD | 468,103 | 55,101,000 | 1.16% | ||
| 23 | NEXT CENTURY GROWTH INVESTORS LLC | 428,835 | 50,478,000 | 1.06% | ||
| 24 | FRANKLIN RESOURCES INC | 396,400 | 46,660,000 | 0.98% | ||
| 25 | DEUTSCHE BANK AG\ | 392,228 | 46,166,000 | 0.97% | ||
| 26 | FARALLON CAPITAL MANAGEMENT LLC | 340,000 | 40,021,000 | 0.84% | ||
| 27 | RENAISSANCE TECHNOLOGIES LLC | 310,458 | 36,544,000 | 0.77% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 298,692 | 35,158,000 | 0.74% | ||
| 29 | TWO SIGMA ADVISERS, LP | 272,004 | 32,223,000 | 0.68% | ||
| 30 | TWO SIGMA INVESTMENTS, LP | 260,783 | 30,697,000 | 0.64% | ||
| 31 | JPMORGAN CHASE & CO | 212,317 | 24,993,000 | 0.52% | ||
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 209,474 | 24,657,000 | 0.52% | ||
| 33 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 204,800 | 24,107,000 | 0.51% | Call | |
| 34 | Century Capital Management, LLC | 200,771 | 23,633,000 | 0.50% | ||
| 35 | LORD, ABBETT & CO. LLC | 199,264 | 23,455,000 | 0.49% | ||
| 36 | BlackRock Investment Management, LLC | 180,008 | 21,189,000 | 0.44% | ||
| 37 | JENNISON ASSOCIATES LLC | 174,546 | 20,546,000 | 0.43% | ||
| 38 | NORGES BANK | 167,093 | 19,669,000 | 0.41% | ||
| 39 | GOLDMAN SACHS GROUP INC | 158,400 | 18,645,000 | 0.39% | Call | |
| 40 | D. E. Shaw & Co., Inc. | 156,022 | 18,365,000 | 0.39% | ||
| 41 | GOLDMAN SACHS GROUP INC | 151,800 | 17,868,000 | 0.37% | Put | |
| 42 | Point72 Asset Management, L.P. | 150,600 | 17,727,000 | 0.37% | ||
| 43 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 148,326 | 17,459,000 | 0.37% | ||
| 44 | PRICE T ROWE ASSOCIATES INC /MD/ | 148,300 | 17,456,000 | 0.37% | ||
| 45 | MORGAN STANLEY | 142,959 | 16,827,000 | 0.35% | ||
| 46 | TEACHERS ADVISORS, LLC | 138,832 | 16,342,000 | 0.34% | ||
| 47 | VOYA INVESTMENT MANAGEMENT LLC | 136,437 | 16,060,000 | 0.34% | ||
| 48 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 133,509 | 15,716,000 | 0.33% | ||
| 49 | HealthCor Management, L.P. | 125,000 | 14,714,000 | 0.31% | ||
| 50 | ROYCE & ASSOCIATES LP | 119,500 | 14,066,000 | 0.30% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
