| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 4,204,702 | 243,242,000 | 10.54% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 3,442,268 | 199,135,000 | 8.63% | ||
| 3 | Palo Alto Investors LP | 3,259,045 | 188,536,000 | 8.17% | ||
| 4 | VANGUARD GROUP INC | 2,299,550 | 133,030,000 | 5.76% | ||
| 5 | FMR LLC | 2,109,049 | 122,008,000 | 5.29% | ||
| 6 | BlackRock Fund Advisors | 1,751,717 | 101,337,000 | 4.39% | ||
| 7 | EAGLE ASSET MANAGEMENT INC | 1,575,950 | 91,168,000 | 3.95% | ||
| 8 | VHCP Management, LLC | 1,178,474 | 68,175,000 | 2.95% | ||
| 9 | FARALLON CAPITAL MANAGEMENT LLC | 1,160,000 | 67,106,000 | 2.91% | ||
| 10 | RHO CAPITAL PARTNERS INC | 1,067,892 | 61,778,000 | 2.68% | ||
| 11 | MILLENNIUM MANAGEMENT LLC | 1,049,789 | 60,730,000 | 2.63% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 1,029,446 | 59,553,000 | 2.58% | ||
| 13 | STATE STREET CORP | 953,840 | 55,176,000 | 2.39% | ||
| 14 | Consonance Capital Management LP | 830,151 | 48,024,000 | 2.08% | ||
| 15 | JENNISON ASSOCIATES LLC | 763,897 | 44,191,000 | 1.91% | ||
| 16 | OppenheimerFunds, Inc. | 600,000 | 34,710,000 | 1.50% | ||
| 17 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 595,300 | 34,438,000 | 1.49% | Call | |
| 18 | Bank of New York Mellon Corp | 587,566 | 33,991,000 | 1.47% | ||
| 19 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 527,835 | 30,535,000 | 1.32% | ||
| 20 | Century Capital Management, LLC | 483,440 | 27,967,000 | 1.21% | ||
| 21 | JANUS HENDERSON INVESTORS US LLC | 415,031 | 24,010,000 | 1.04% | ||
| 22 | NORTHERN TRUST CORP | 411,513 | 23,807,000 | 1.03% | ||
| 23 | NEXT CENTURY GROWTH INVESTORS LLC | 404,168 | 23,381,000 | 1.01% | ||
| 24 | Tourbillon Capital Partners, L.P. | 400,000 | 23,140,000 | 1.00% | ||
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 317,631 | 18,375,000 | 0.80% | ||
| 26 | OXFORD ASSET MANAGEMENT LLP | 301,217 | 17,425,000 | 0.76% | ||
| 27 | DEUTSCHE BANK AG\ | 291,507 | 16,860,000 | 0.73% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 286,550 | 16,576,000 | 0.72% | ||
| 29 | LOOMIS SAYLES & CO L P | 284,936 | 16,484,000 | 0.71% | ||
| 30 | ROYCE & ASSOCIATES LP | 284,500 | 16,458,000 | 0.71% | ||
| 31 | QVT Financial LP | 284,383 | 16,452,000 | 0.71% | ||
| 32 | MARSHALL WACE, LLP | 268,475 | 15,531,000 | 0.67% | ||
| 33 | Lombard Odier Asset Management (USA) Corp | 230,223 | 13,318,000 | 0.58% | ||
| 34 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 228,799 | 13,236,000 | 0.57% | ||
| 35 | BLACKROCK ADVISORS LLC | 224,984 | 13,015,000 | 0.56% | ||
| 36 | CADIAN CAPITAL MANAGEMENT, LP | 220,000 | 12,727,000 | 0.55% | ||
| 37 | LORD, ABBETT & CO. LLC | 214,732 | 12,422,000 | 0.54% | ||
| 38 | Invesco Ltd. | 210,079 | 12,153,000 | 0.53% | ||
| 39 | TWO SIGMA INVESTMENTS, LP | 188,776 | 10,921,000 | 0.47% | ||
| 40 | Broadfin Capital, LLC | 184,320 | 10,663,000 | 0.46% | ||
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 182,100 | 10,534,000 | 0.46% | Call | |
| 42 | AMERICAN CENTURY COMPANIES INC | 178,952 | 10,352,000 | 0.45% | ||
| 43 | MORGAN STANLEY | 173,132 | 10,016,000 | 0.43% | ||
| 44 | CREDIT SUISSE AG/ | 157,302 | 9,101,000 | 0.39% | ||
| 45 | TIAA CREF INVESTMENT MANAGEMENT LLC | 153,071 | 8,855,000 | 0.38% | ||
| 46 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 143,200 | 8,284,000 | 0.36% | Put | |
| 47 | UBS Group AG | 126,358 | 7,310,000 | 0.32% | ||
| 48 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 126,350 | 7,310,000 | 0.32% | ||
| 49 | MANAGED ACCOUNT ADVISORS LLC | 126,107 | 7,296,000 | 0.32% | ||
| 50 | THRIVENT FINANCIAL FOR LUTHERANS | 120,990 | 6,999,000 | 0.30% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
