| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 3,625,498 | 280,722,000 | 9.26% | ||
| 2 | FMR LLC | 3,320,494 | 257,106,000 | 8.49% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 3,164,774 | 245,049,000 | 8.09% | ||
| 4 | Palo Alto Investors LP | 3,103,027 | 240,267,000 | 7.93% | ||
| 5 | VANGUARD GROUP INC | 2,439,661 | 188,902,000 | 6.23% | ||
| 6 | BlackRock Fund Advisors | 1,838,909 | 142,387,000 | 4.70% | ||
| 7 | JANUS HENDERSON INVESTORS US LLC | 1,602,222 | 124,060,000 | 4.09% | ||
| 8 | EAGLE ASSET MANAGEMENT INC | 1,526,458 | 118,193,000 | 3.90% | ||
| 9 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 1,345,700 | 104,198,000 | 3.44% | Call | |
| 10 | VHCP Management, LLC | 1,178,474 | 91,249,000 | 3.01% | ||
| 11 | RHO CAPITAL PARTNERS INC | 1,067,892 | 82,687,000 | 2.73% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 955,328 | 73,971,000 | 2.44% | ||
| 13 | FARALLON CAPITAL MANAGEMENT LLC | 760,000 | 58,847,000 | 1.94% | ||
| 14 | MILLENNIUM MANAGEMENT LLC | 736,962 | 57,063,000 | 1.88% | ||
| 15 | NEXT CENTURY GROWTH INVESTORS LLC | 612,264 | 47,407,000 | 1.56% | ||
| 16 | OppenheimerFunds, Inc. | 500,000 | 38,715,000 | 1.28% | ||
| 17 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 481,542 | 37,286,000 | 1.23% | ||
| 18 | JENNISON ASSOCIATES LLC | 446,880 | 34,602,000 | 1.14% | ||
| 19 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 434,800 | 33,667,000 | 1.11% | Call | |
| 20 | Invesco Ltd. | 426,113 | 32,994,000 | 1.09% | ||
| 21 | NORTHERN TRUST CORP | 375,552 | 29,078,000 | 0.96% | ||
| 22 | Tourbillon Capital Partners, L.P. | 350,000 | 27,101,000 | 0.89% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 298,271 | 23,094,000 | 0.76% | ||
| 24 | TWO SIGMA INVESTMENTS, LP | 280,021 | 21,682,000 | 0.72% | ||
| 25 | BLACKROCK ADVISORS LLC | 271,269 | 21,005,000 | 0.69% | ||
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 267,600 | 20,720,000 | 0.68% | Put | |
| 27 | Bank of New York Mellon Corp | 252,719 | 19,568,000 | 0.65% | ||
| 28 | Century Capital Management, LLC | 241,854 | 18,727,000 | 0.62% | ||
| 29 | DEUTSCHE BANK AG\ | 229,615 | 17,778,000 | 0.59% | ||
| 30 | QVT Financial LP | 198,246 | 15,350,000 | 0.51% | ||
| 31 | MORGAN STANLEY | 192,487 | 14,904,000 | 0.49% | ||
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 192,417 | 14,899,000 | 0.49% | ||
| 33 | CREDIT SUISSE AG/ | 184,683 | 14,300,000 | 0.47% | ||
| 34 | GOLDMAN SACHS GROUP INC | 177,800 | 13,767,000 | 0.45% | Call | |
| 35 | LOOMIS SAYLES & CO L P | 177,577 | 13,750,000 | 0.45% | ||
| 36 | D. E. Shaw & Co., Inc. | 175,966 | 13,625,000 | 0.45% | ||
| 37 | HWG Holdings LP | 176,536 | 13,426,000 | 0.44% | ||
| 38 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 171,782 | 13,301,000 | 0.44% | ||
| 39 | CITADEL ADVISORS LLC | 167,993 | 13,008,000 | 0.43% | ||
| 40 | ROYCE & ASSOCIATES LP | 159,500 | 12,350,000 | 0.41% | ||
| 41 | JPMORGAN CHASE & CO | 158,768 | 12,294,000 | 0.41% | ||
| 42 | Asset Management One Co., Ltd. | 157,336 | 11,965,000 | 0.39% | ||
| 43 | BlackRock Investment Management, LLC | 150,095 | 11,622,000 | 0.38% | ||
| 44 | Lombard Odier Asset Management (USA) Corp | 150,000 | 11,615,000 | 0.38% | ||
| 45 | PRICE T ROWE ASSOCIATES INC /MD/ | 139,700 | 10,817,000 | 0.36% | ||
| 46 | OXFORD ASSET MANAGEMENT LLP | 136,381 | 10,560,000 | 0.35% | ||
| 47 | LORD, ABBETT & CO. LLC | 133,651 | 10,349,000 | 0.34% | ||
| 48 | TWO SIGMA ADVISERS, LP | 133,300 | 10,321,000 | 0.34% | ||
| 49 | ORBIMED ADVISORS LLC | 129,000 | 9,988,000 | 0.33% | ||
| 50 | MARSHALL WACE, LLP | 126,484 | 9,794,000 | 0.32% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
